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3KM0

17betaHSD1 in complex with 3beta-diol

Functional Information from GO Data
ChainGOidnamespacecontents
A0003824molecular_functioncatalytic activity
A0004303molecular_functionestradiol 17-beta-dehydrogenase [NAD(P)] activity
A0005496molecular_functionsteroid binding
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006629biological_processlipid metabolic process
A0006694biological_processsteroid biosynthetic process
A0006703biological_processestrogen biosynthetic process
A0007040biological_processlysosome organization
A0007519biological_processskeletal muscle tissue development
A0008210biological_processestrogen metabolic process
A0010467biological_processgene expression
A0016491molecular_functionoxidoreductase activity
A0030283molecular_functiontestosterone dehydrogenase [NAD(P)] activity
A0035410molecular_functiondihydrotestosterone 17-beta-dehydrogenase activity
A0036094molecular_functionsmall molecule binding
A0042803molecular_functionprotein homodimerization activity
A0047035molecular_functiontestosterone dehydrogenase (NAD+) activity
A0047045molecular_functiontestosterone 17-beta-dehydrogenase (NADP+) activity
A0050661molecular_functionNADP binding
A0060348biological_processbone development
A0060612biological_processadipose tissue development
A0061370biological_processtestosterone biosynthetic process
A0070401molecular_functionNADP+ binding
A0071248biological_processcellular response to metal ion
A0072582molecular_function17-beta-hydroxysteroid dehydrogenase (NADP+) activity
A1903924molecular_functionestradiol binding
B0003824molecular_functioncatalytic activity
B0004303molecular_functionestradiol 17-beta-dehydrogenase [NAD(P)] activity
B0005496molecular_functionsteroid binding
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006629biological_processlipid metabolic process
B0006694biological_processsteroid biosynthetic process
B0006703biological_processestrogen biosynthetic process
B0007040biological_processlysosome organization
B0007519biological_processskeletal muscle tissue development
B0008210biological_processestrogen metabolic process
B0010467biological_processgene expression
B0016491molecular_functionoxidoreductase activity
B0030283molecular_functiontestosterone dehydrogenase [NAD(P)] activity
B0035410molecular_functiondihydrotestosterone 17-beta-dehydrogenase activity
B0036094molecular_functionsmall molecule binding
B0042803molecular_functionprotein homodimerization activity
B0047035molecular_functiontestosterone dehydrogenase (NAD+) activity
B0047045molecular_functiontestosterone 17-beta-dehydrogenase (NADP+) activity
B0050661molecular_functionNADP binding
B0060348biological_processbone development
B0060612biological_processadipose tissue development
B0061370biological_processtestosterone biosynthetic process
B0070401molecular_functionNADP+ binding
B0071248biological_processcellular response to metal ion
B0072582molecular_function17-beta-hydroxysteroid dehydrogenase (NADP+) activity
B1903924molecular_functionestradiol binding
Functional Information from PDB Data
site_idAC1
Number of Residues9
DetailsBINDING SITE FOR RESIDUE AOM A 401
ChainResidue
ASER142
AVAL143
ALEU149
ATYR155
AHIS221
ASER222
APHE226
APHE259
AVAL283

site_idAC2
Number of Residues8
DetailsBINDING SITE FOR RESIDUE AOM B 401
ChainResidue
BSER142
BTYR155
BTYR218
BHIS221
BSER222
BPHE226
BPHE259
BNAP402

site_idAC3
Number of Residues30
DetailsBINDING SITE FOR RESIDUE NAP B 402
ChainResidue
BGLY9
BCYS10
BSER11
BSER12
BILE14
BGLY15
BTHR35
BLEU36
BARG37
BLEU64
BASP65
BVAL66
BASN90
BALA91
BGLY92
BLEU93
BTHR140
BGLY141
BLYS159
BCYS185
BGLY186
BPRO187
BVAL188
BHOH557
BAOM401
BHOH520
BHOH539
BHOH503
BHOH530
BHOH538

site_idAC4
Number of Residues24
DetailsBINDING SITE FOR RESIDUE NAP A 402
ChainResidue
AGLY9
ACYS10
ASER11
ASER12
AILE14
AGLY15
ALEU36
AARG37
AASP65
AVAL66
AARG67
AASN90
AALA91
AGLY92
AVAL113
ATHR140
AGLY141
ALYS159
ACYS185
AGLY186
APRO187
AVAL188
AHOH547
AHOH537

Functional Information from PROSITE/UniProt
site_idPS00061
Number of Residues29
DetailsADH_SHORT Short-chain dehydrogenases/reductases family signature. SvgglmglpfNdvYCASKFALeGLCeSLA
ChainResidueDetails
ASER142-ALA170

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Proton acceptor
ChainResidueDetails
ATYR155
BTYR155

site_idSWS_FT_FI2
Number of Residues8
DetailsBINDING: BINDING => ECO:0000269|PubMed:8805577
ChainResidueDetails
ASER142
ALYS159
BGLY9
BASP65
BSER142
BLYS159
AGLY9
AASP65

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: Phosphoserine; by PKA => ECO:0000269|PubMed:8994190
ChainResidueDetails
ASER134
BSER134

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PDB entries from 2024-06-12

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