3JR8
Crystal Structure of BthTX-II (Asp49-PLA2 from Bothrops jararacussu snake venom) with calcium ions
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004623 | molecular_function | phospholipase A2 activity |
| A | 0005509 | molecular_function | calcium ion binding |
| A | 0005543 | molecular_function | phospholipid binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0006644 | biological_process | phospholipid metabolic process |
| A | 0016042 | biological_process | lipid catabolic process |
| A | 0035821 | biological_process | modulation of process of another organism |
| A | 0042130 | biological_process | negative regulation of T cell proliferation |
| A | 0047498 | molecular_function | calcium-dependent phospholipase A2 activity |
| A | 0050482 | biological_process | arachidonic acid secretion |
| A | 0090729 | molecular_function | toxin activity |
| B | 0004623 | molecular_function | phospholipase A2 activity |
| B | 0005509 | molecular_function | calcium ion binding |
| B | 0005543 | molecular_function | phospholipid binding |
| B | 0005576 | cellular_component | extracellular region |
| B | 0006644 | biological_process | phospholipid metabolic process |
| B | 0016042 | biological_process | lipid catabolic process |
| B | 0035821 | biological_process | modulation of process of another organism |
| B | 0042130 | biological_process | negative regulation of T cell proliferation |
| B | 0047498 | molecular_function | calcium-dependent phospholipase A2 activity |
| B | 0050482 | biological_process | arachidonic acid secretion |
| B | 0090729 | molecular_function | toxin activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA B 134 |
| Chain | Residue |
| B | TYR22 |
| B | THR41 |
| B | PHE106 |
| B | ASN109 |
| B | LEU110 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CA B 135 |
| Chain | Residue |
| B | ASP39 |
| B | ALA40 |
| B | THR41 |
| B | THR112 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA A 134 |
| Chain | Residue |
| A | TYR22 |
| A | THR41 |
| A | PHE106 |
| A | LEU110 |
| A | TYR113 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CA A 135 |
| Chain | Residue |
| A | ASP39 |
| A | THR41 |
| A | ASN109 |
| A | THR112 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | SITE: Putative hydrophobic membrane-disrupting site (MDiS) => ECO:0000250|UniProtKB:P20474 |
| Chain | Residue | Details |
| A | TRP3 | |
| A | LEU10 | |
| A | LEU17 | |
| B | TRP3 | |
| B | LEU10 | |
| B | LEU17 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | SITE: Putative membrane-disrupting site (MDiS) => ECO:0000250|UniProtKB:P20474 |
| Chain | Residue | Details |
| A | LYS16 | |
| B | LYS16 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | SITE: Putative cationic membrane-docking site (MDoS) => ECO:0000250|UniProtKB:P20474 |
| Chain | Residue | Details |
| A | ARG72 | |
| B | ARG72 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | SITE: Important residue of the cationic membrane-docking site (MDoS) => ECO:0000250|UniProtKB:I6L8L6 |
| Chain | Residue | Details |
| A | LYS115 | |
| B | LYS115 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | SITE: Hydrophobic membrane-disruption site (MDiS) => ECO:0000250|UniProtKB:I6L8L6 |
| Chain | Residue | Details |
| A | LEU125 | |
| B | LEU125 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | SITE: Cationic membrane-docking site (MDoS) => ECO:0000250|UniProtKB:I6L8L6 |
| Chain | Residue | Details |
| A | LYS128 | |
| B | LYS128 |
