3JC2

The structure of the mammalian Sec61 channel opened by a signal sequence

Functional Information from GO Data

Chain	GOid	namespace	contents
1	0005048	molecular_function	signal sequence binding
1	0005515	molecular_function	protein binding
1	0005783	cellular_component	endoplasmic reticulum
1	0005784	cellular_component	Sec61 translocon complex
1	0005789	cellular_component	endoplasmic reticulum membrane
1	0006613	biological_process	cotranslational protein targeting to membrane
1	0006616	biological_process	SRP-dependent cotranslational protein targeting to membrane, translocation
1	0008320	molecular_function	protein transmembrane transporter activity
1	0015031	biological_process	protein transport
1	0016020	cellular_component	membrane
1	0031204	biological_process	post-translational protein targeting to membrane, translocation
1	0039019	biological_process	pronephric nephron development
1	0043022	molecular_function	ribosome binding
1	0045047	biological_process	protein targeting to ER
1	0045048	biological_process	protein insertion into ER membrane
2	0005543	molecular_function	phospholipid binding
2	0005783	cellular_component	endoplasmic reticulum
2	0005789	cellular_component	endoplasmic reticulum membrane
2	0006605	biological_process	protein targeting
2	0006886	biological_process	intracellular protein transport
2	0008320	molecular_function	protein transmembrane transporter activity
2	0015031	biological_process	protein transport
2	0016020	cellular_component	membrane
2	0022406	biological_process	membrane docking
2	0031204	biological_process	post-translational protein targeting to membrane, translocation
2	0043022	molecular_function	ribosome binding
2	0045047	biological_process	protein targeting to ER
2	0071261	cellular_component	Ssh1 translocon complex

Functional Information from PROSITE/UniProt

site_id	PS00755
Number of Residues	20
Details	SECY_1 Protein secY signature 1. TLMeLGIsPIVtSGLIMQLL

Chain	Residue	Details
1	THR75-LEU94

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site_id	PS00756
Number of Residues	19
Details	SECY_2 Protein secY signature 2. LLdElLQkgyGLGSGiSLF

Chain	Residue	Details
1	LEU164-PHE182

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site_id	PS01067
Number of Residues	29
Details	SECE_SEC61G Protein secE/sec61-gamma signature. FvKDsIrlVkRctKPdrkEfqkiaMATAI

Chain	Residue	Details
2	PHE14-ILE42

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	25
Details	TRANSMEM: Helical => ECO:0000269|PubMed:36261528, ECO:0007744|PDB:7TM3, ECO:0007744|PDB:7TUT

Chain	Residue	Details
2	ILE36-ILE61
1	LYS98-ARG109
1	LEU168-SER177
1	GLY260-TYR285
1	ILE380-ALA420
1	GLU459-PHE476

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site_id	SWS_FT_FI2
Number of Residues	6
Details	TOPO_DOM: Extracellular => ECO:0000269|PubMed:36261528, ECO:0007744|PDB:7TM3, ECO:0007744|PDB:7TUT

Chain	Residue	Details
2	ASN62-GLY68
1	ILE81-ALA97
1	ALA110-TYR131
1	LEU149-GLU167
1	GLY178-PHE196
1	LEU242-GLN259
1	THR286-GLN306
1	ASP357-TRP379
1	ALA421-PHE437
1	GLY444-PHE458

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site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P60059

Chain	Residue	Details
1	VAL132-CYS148
1	SER197-ASN241
1	MET307-GLU356
1	LEU438-SER443
2	SER18

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