3JBT

Atomic structure of the Apaf-1 apoptosome

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0001666	biological_process	response to hypoxia
A	0001822	biological_process	kidney development
A	0001843	biological_process	neural tube closure
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005576	cellular_component	extracellular region
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006915	biological_process	apoptotic process
A	0006919	biological_process	activation of cysteine-type endopeptidase activity involved in apoptotic process
A	0007399	biological_process	nervous system development
A	0007420	biological_process	brain development
A	0007584	biological_process	response to nutrient
A	0008635	biological_process	activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
A	0008656	molecular_function	cysteine-type endopeptidase activator activity involved in apoptotic process
A	0010659	biological_process	cardiac muscle cell apoptotic process
A	0030154	biological_process	cell differentiation
A	0030900	biological_process	forebrain development
A	0031072	molecular_function	heat shock protein binding
A	0032991	cellular_component	protein-containing complex
A	0034774	cellular_component	secretory granule lumen
A	0042802	molecular_function	identical protein binding
A	0042981	biological_process	regulation of apoptotic process
A	0043065	biological_process	positive regulation of apoptotic process
A	0043293	cellular_component	apoptosome
A	0043531	molecular_function	ADP binding
A	0051402	biological_process	neuron apoptotic process
A	0070059	biological_process	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
A	0070062	cellular_component	extracellular exosome
A	0071560	biological_process	cellular response to transforming growth factor beta stimulus
A	0072432	biological_process	response to G1 DNA damage checkpoint signaling
A	0097190	biological_process	apoptotic signaling pathway
A	0097193	biological_process	intrinsic apoptotic signaling pathway
A	1902510	biological_process	regulation of apoptotic DNA fragmentation
A	1904813	cellular_component	ficolin-1-rich granule lumen
A	2001235	biological_process	positive regulation of apoptotic signaling pathway
B	0005515	molecular_function	protein binding
B	0005739	cellular_component	mitochondrion
B	0005758	cellular_component	mitochondrial intermembrane space
B	0005829	cellular_component	cytosol
B	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
B	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
B	0006915	biological_process	apoptotic process
B	0008289	molecular_function	lipid binding
B	0009055	molecular_function	electron transfer activity
B	0018063	biological_process	cytochrome c-heme linkage
B	0020037	molecular_function	heme binding
B	0042802	molecular_function	identical protein binding
B	0043065	biological_process	positive regulation of apoptotic process
B	0043280	biological_process	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
B	0046872	molecular_function	metal ion binding
B	0070069	cellular_component	cytochrome complex
B	0070469	cellular_component	respirasome
B	2001056	biological_process	positive regulation of cysteine-type endopeptidase activity
C	0000166	molecular_function	nucleotide binding
C	0001666	biological_process	response to hypoxia
C	0001822	biological_process	kidney development
C	0001843	biological_process	neural tube closure
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005576	cellular_component	extracellular region
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006915	biological_process	apoptotic process
C	0006919	biological_process	activation of cysteine-type endopeptidase activity involved in apoptotic process
C	0007399	biological_process	nervous system development
C	0007420	biological_process	brain development
C	0007584	biological_process	response to nutrient
C	0008635	biological_process	activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
C	0008656	molecular_function	cysteine-type endopeptidase activator activity involved in apoptotic process
C	0010659	biological_process	cardiac muscle cell apoptotic process
C	0030154	biological_process	cell differentiation
C	0030900	biological_process	forebrain development
C	0031072	molecular_function	heat shock protein binding
C	0032991	cellular_component	protein-containing complex
C	0034774	cellular_component	secretory granule lumen
C	0042802	molecular_function	identical protein binding
C	0042981	biological_process	regulation of apoptotic process
C	0043065	biological_process	positive regulation of apoptotic process
C	0043293	cellular_component	apoptosome
C	0043531	molecular_function	ADP binding
C	0051402	biological_process	neuron apoptotic process
C	0070059	biological_process	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
C	0070062	cellular_component	extracellular exosome
C	0071560	biological_process	cellular response to transforming growth factor beta stimulus
C	0072432	biological_process	response to G1 DNA damage checkpoint signaling
C	0097190	biological_process	apoptotic signaling pathway
C	0097193	biological_process	intrinsic apoptotic signaling pathway
C	1902510	biological_process	regulation of apoptotic DNA fragmentation
C	1904813	cellular_component	ficolin-1-rich granule lumen
C	2001235	biological_process	positive regulation of apoptotic signaling pathway
D	0005515	molecular_function	protein binding
D	0005739	cellular_component	mitochondrion
D	0005758	cellular_component	mitochondrial intermembrane space
D	0005829	cellular_component	cytosol
D	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
D	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
D	0006915	biological_process	apoptotic process
D	0008289	molecular_function	lipid binding
D	0009055	molecular_function	electron transfer activity
D	0018063	biological_process	cytochrome c-heme linkage
D	0020037	molecular_function	heme binding
D	0042802	molecular_function	identical protein binding
D	0043065	biological_process	positive regulation of apoptotic process
D	0043280	biological_process	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
D	0046872	molecular_function	metal ion binding
D	0070069	cellular_component	cytochrome complex
D	0070469	cellular_component	respirasome
D	2001056	biological_process	positive regulation of cysteine-type endopeptidase activity
E	0000166	molecular_function	nucleotide binding
E	0001666	biological_process	response to hypoxia
E	0001822	biological_process	kidney development
E	0001843	biological_process	neural tube closure
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005576	cellular_component	extracellular region
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006915	biological_process	apoptotic process
E	0006919	biological_process	activation of cysteine-type endopeptidase activity involved in apoptotic process
E	0007399	biological_process	nervous system development
E	0007420	biological_process	brain development
E	0007584	biological_process	response to nutrient
E	0008635	biological_process	activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
E	0008656	molecular_function	cysteine-type endopeptidase activator activity involved in apoptotic process
E	0010659	biological_process	cardiac muscle cell apoptotic process
E	0030154	biological_process	cell differentiation
E	0030900	biological_process	forebrain development
E	0031072	molecular_function	heat shock protein binding
E	0032991	cellular_component	protein-containing complex
E	0034774	cellular_component	secretory granule lumen
E	0042802	molecular_function	identical protein binding
E	0042981	biological_process	regulation of apoptotic process
E	0043065	biological_process	positive regulation of apoptotic process
E	0043293	cellular_component	apoptosome
E	0043531	molecular_function	ADP binding
E	0051402	biological_process	neuron apoptotic process
E	0070059	biological_process	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
E	0070062	cellular_component	extracellular exosome
E	0071560	biological_process	cellular response to transforming growth factor beta stimulus
E	0072432	biological_process	response to G1 DNA damage checkpoint signaling
E	0097190	biological_process	apoptotic signaling pathway
E	0097193	biological_process	intrinsic apoptotic signaling pathway
E	1902510	biological_process	regulation of apoptotic DNA fragmentation
E	1904813	cellular_component	ficolin-1-rich granule lumen
E	2001235	biological_process	positive regulation of apoptotic signaling pathway
F	0005515	molecular_function	protein binding
F	0005739	cellular_component	mitochondrion
F	0005758	cellular_component	mitochondrial intermembrane space
F	0005829	cellular_component	cytosol
F	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
F	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
F	0006915	biological_process	apoptotic process
F	0008289	molecular_function	lipid binding
F	0009055	molecular_function	electron transfer activity
F	0018063	biological_process	cytochrome c-heme linkage
F	0020037	molecular_function	heme binding
F	0042802	molecular_function	identical protein binding
F	0043065	biological_process	positive regulation of apoptotic process
F	0043280	biological_process	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
F	0046872	molecular_function	metal ion binding
F	0070069	cellular_component	cytochrome complex
F	0070469	cellular_component	respirasome
F	2001056	biological_process	positive regulation of cysteine-type endopeptidase activity
G	0000166	molecular_function	nucleotide binding
G	0001666	biological_process	response to hypoxia
G	0001822	biological_process	kidney development
G	0001843	biological_process	neural tube closure
G	0005515	molecular_function	protein binding
G	0005524	molecular_function	ATP binding
G	0005576	cellular_component	extracellular region
G	0005634	cellular_component	nucleus
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0006915	biological_process	apoptotic process
G	0006919	biological_process	activation of cysteine-type endopeptidase activity involved in apoptotic process
G	0007399	biological_process	nervous system development
G	0007420	biological_process	brain development
G	0007584	biological_process	response to nutrient
G	0008635	biological_process	activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
G	0008656	molecular_function	cysteine-type endopeptidase activator activity involved in apoptotic process
G	0010659	biological_process	cardiac muscle cell apoptotic process
G	0030154	biological_process	cell differentiation
G	0030900	biological_process	forebrain development
G	0031072	molecular_function	heat shock protein binding
G	0032991	cellular_component	protein-containing complex
G	0034774	cellular_component	secretory granule lumen
G	0042802	molecular_function	identical protein binding
G	0042981	biological_process	regulation of apoptotic process
G	0043065	biological_process	positive regulation of apoptotic process
G	0043293	cellular_component	apoptosome
G	0043531	molecular_function	ADP binding
G	0051402	biological_process	neuron apoptotic process
G	0070059	biological_process	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
G	0070062	cellular_component	extracellular exosome
G	0071560	biological_process	cellular response to transforming growth factor beta stimulus
G	0072432	biological_process	response to G1 DNA damage checkpoint signaling
G	0097190	biological_process	apoptotic signaling pathway
G	0097193	biological_process	intrinsic apoptotic signaling pathway
G	1902510	biological_process	regulation of apoptotic DNA fragmentation
G	1904813	cellular_component	ficolin-1-rich granule lumen
G	2001235	biological_process	positive regulation of apoptotic signaling pathway
H	0005515	molecular_function	protein binding
H	0005739	cellular_component	mitochondrion
H	0005758	cellular_component	mitochondrial intermembrane space
H	0005829	cellular_component	cytosol
H	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
H	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
H	0006915	biological_process	apoptotic process
H	0008289	molecular_function	lipid binding
H	0009055	molecular_function	electron transfer activity
H	0018063	biological_process	cytochrome c-heme linkage
H	0020037	molecular_function	heme binding
H	0042802	molecular_function	identical protein binding
H	0043065	biological_process	positive regulation of apoptotic process
H	0043280	biological_process	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
H	0046872	molecular_function	metal ion binding
H	0070069	cellular_component	cytochrome complex
H	0070469	cellular_component	respirasome
H	2001056	biological_process	positive regulation of cysteine-type endopeptidase activity
I	0000166	molecular_function	nucleotide binding
I	0001666	biological_process	response to hypoxia
I	0001822	biological_process	kidney development
I	0001843	biological_process	neural tube closure
I	0005515	molecular_function	protein binding
I	0005524	molecular_function	ATP binding
I	0005576	cellular_component	extracellular region
I	0005634	cellular_component	nucleus
I	0005737	cellular_component	cytoplasm
I	0005829	cellular_component	cytosol
I	0006915	biological_process	apoptotic process
I	0006919	biological_process	activation of cysteine-type endopeptidase activity involved in apoptotic process
I	0007399	biological_process	nervous system development
I	0007420	biological_process	brain development
I	0007584	biological_process	response to nutrient
I	0008635	biological_process	activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
I	0008656	molecular_function	cysteine-type endopeptidase activator activity involved in apoptotic process
I	0010659	biological_process	cardiac muscle cell apoptotic process
I	0030154	biological_process	cell differentiation
I	0030900	biological_process	forebrain development
I	0031072	molecular_function	heat shock protein binding
I	0032991	cellular_component	protein-containing complex
I	0034774	cellular_component	secretory granule lumen
I	0042802	molecular_function	identical protein binding
I	0042981	biological_process	regulation of apoptotic process
I	0043065	biological_process	positive regulation of apoptotic process
I	0043293	cellular_component	apoptosome
I	0043531	molecular_function	ADP binding
I	0051402	biological_process	neuron apoptotic process
I	0070059	biological_process	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
I	0070062	cellular_component	extracellular exosome
I	0071560	biological_process	cellular response to transforming growth factor beta stimulus
I	0072432	biological_process	response to G1 DNA damage checkpoint signaling
I	0097190	biological_process	apoptotic signaling pathway
I	0097193	biological_process	intrinsic apoptotic signaling pathway
I	1902510	biological_process	regulation of apoptotic DNA fragmentation
I	1904813	cellular_component	ficolin-1-rich granule lumen
I	2001235	biological_process	positive regulation of apoptotic signaling pathway
J	0005515	molecular_function	protein binding
J	0005739	cellular_component	mitochondrion
J	0005758	cellular_component	mitochondrial intermembrane space
J	0005829	cellular_component	cytosol
J	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
J	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
J	0006915	biological_process	apoptotic process
J	0008289	molecular_function	lipid binding
J	0009055	molecular_function	electron transfer activity
J	0018063	biological_process	cytochrome c-heme linkage
J	0020037	molecular_function	heme binding
J	0042802	molecular_function	identical protein binding
J	0043065	biological_process	positive regulation of apoptotic process
J	0043280	biological_process	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
J	0046872	molecular_function	metal ion binding
J	0070069	cellular_component	cytochrome complex
J	0070469	cellular_component	respirasome
J	2001056	biological_process	positive regulation of cysteine-type endopeptidase activity
K	0000166	molecular_function	nucleotide binding
K	0001666	biological_process	response to hypoxia
K	0001822	biological_process	kidney development
K	0001843	biological_process	neural tube closure
K	0005515	molecular_function	protein binding
K	0005524	molecular_function	ATP binding
K	0005576	cellular_component	extracellular region
K	0005634	cellular_component	nucleus
K	0005737	cellular_component	cytoplasm
K	0005829	cellular_component	cytosol
K	0006915	biological_process	apoptotic process
K	0006919	biological_process	activation of cysteine-type endopeptidase activity involved in apoptotic process
K	0007399	biological_process	nervous system development
K	0007420	biological_process	brain development
K	0007584	biological_process	response to nutrient
K	0008635	biological_process	activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
K	0008656	molecular_function	cysteine-type endopeptidase activator activity involved in apoptotic process
K	0010659	biological_process	cardiac muscle cell apoptotic process
K	0030154	biological_process	cell differentiation
K	0030900	biological_process	forebrain development
K	0031072	molecular_function	heat shock protein binding
K	0032991	cellular_component	protein-containing complex
K	0034774	cellular_component	secretory granule lumen
K	0042802	molecular_function	identical protein binding
K	0042981	biological_process	regulation of apoptotic process
K	0043065	biological_process	positive regulation of apoptotic process
K	0043293	cellular_component	apoptosome
K	0043531	molecular_function	ADP binding
K	0051402	biological_process	neuron apoptotic process
K	0070059	biological_process	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
K	0070062	cellular_component	extracellular exosome
K	0071560	biological_process	cellular response to transforming growth factor beta stimulus
K	0072432	biological_process	response to G1 DNA damage checkpoint signaling
K	0097190	biological_process	apoptotic signaling pathway
K	0097193	biological_process	intrinsic apoptotic signaling pathway
K	1902510	biological_process	regulation of apoptotic DNA fragmentation
K	1904813	cellular_component	ficolin-1-rich granule lumen
K	2001235	biological_process	positive regulation of apoptotic signaling pathway
L	0005515	molecular_function	protein binding
L	0005739	cellular_component	mitochondrion
L	0005758	cellular_component	mitochondrial intermembrane space
L	0005829	cellular_component	cytosol
L	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
L	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
L	0006915	biological_process	apoptotic process
L	0008289	molecular_function	lipid binding
L	0009055	molecular_function	electron transfer activity
L	0018063	biological_process	cytochrome c-heme linkage
L	0020037	molecular_function	heme binding
L	0042802	molecular_function	identical protein binding
L	0043065	biological_process	positive regulation of apoptotic process
L	0043280	biological_process	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
L	0046872	molecular_function	metal ion binding
L	0070069	cellular_component	cytochrome complex
L	0070469	cellular_component	respirasome
L	2001056	biological_process	positive regulation of cysteine-type endopeptidase activity
M	0000166	molecular_function	nucleotide binding
M	0001666	biological_process	response to hypoxia
M	0001822	biological_process	kidney development
M	0001843	biological_process	neural tube closure
M	0005515	molecular_function	protein binding
M	0005524	molecular_function	ATP binding
M	0005576	cellular_component	extracellular region
M	0005634	cellular_component	nucleus
M	0005737	cellular_component	cytoplasm
M	0005829	cellular_component	cytosol
M	0006915	biological_process	apoptotic process
M	0006919	biological_process	activation of cysteine-type endopeptidase activity involved in apoptotic process
M	0007399	biological_process	nervous system development
M	0007420	biological_process	brain development
M	0007584	biological_process	response to nutrient
M	0008635	biological_process	activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
M	0008656	molecular_function	cysteine-type endopeptidase activator activity involved in apoptotic process
M	0010659	biological_process	cardiac muscle cell apoptotic process
M	0030154	biological_process	cell differentiation
M	0030900	biological_process	forebrain development
M	0031072	molecular_function	heat shock protein binding
M	0032991	cellular_component	protein-containing complex
M	0034774	cellular_component	secretory granule lumen
M	0042802	molecular_function	identical protein binding
M	0042981	biological_process	regulation of apoptotic process
M	0043065	biological_process	positive regulation of apoptotic process
M	0043293	cellular_component	apoptosome
M	0043531	molecular_function	ADP binding
M	0051402	biological_process	neuron apoptotic process
M	0070059	biological_process	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
M	0070062	cellular_component	extracellular exosome
M	0071560	biological_process	cellular response to transforming growth factor beta stimulus
M	0072432	biological_process	response to G1 DNA damage checkpoint signaling
M	0097190	biological_process	apoptotic signaling pathway
M	0097193	biological_process	intrinsic apoptotic signaling pathway
M	1902510	biological_process	regulation of apoptotic DNA fragmentation
M	1904813	cellular_component	ficolin-1-rich granule lumen
M	2001235	biological_process	positive regulation of apoptotic signaling pathway
N	0005515	molecular_function	protein binding
N	0005739	cellular_component	mitochondrion
N	0005758	cellular_component	mitochondrial intermembrane space
N	0005829	cellular_component	cytosol
N	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
N	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
N	0006915	biological_process	apoptotic process
N	0008289	molecular_function	lipid binding
N	0009055	molecular_function	electron transfer activity
N	0018063	biological_process	cytochrome c-heme linkage
N	0020037	molecular_function	heme binding
N	0042802	molecular_function	identical protein binding
N	0043065	biological_process	positive regulation of apoptotic process
N	0043280	biological_process	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
N	0046872	molecular_function	metal ion binding
N	0070069	cellular_component	cytochrome complex
N	0070469	cellular_component	respirasome
N	2001056	biological_process	positive regulation of cysteine-type endopeptidase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	BINDING SITE FOR RESIDUE DTP A 1301

Chain	Residue
A	VAL125
A	PRO321
A	SER325
A	TYR359
A	MG1302
A	PHE126
A	VAL127
A	GLY159
A	LYS160
A	SER161
A	VAL162
A	ASP244
A	ARG265

---

site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG A 1302

Chain	Residue
A	SER161
A	ASP243
A	DTP1301

---

site_id	AC3
Number of Residues	22
Details	BINDING SITE FOR RESIDUE HEM B 201

Chain	Residue
B	LYS13
B	CYS14
B	CYS17
B	HIS18
B	THR28
B	GLY29
B	PRO30
B	LEU32
B	ARG38
B	THR40
B	GLY41
B	TYR48
B	THR49
B	ASN52
B	TRP59
B	TYR67
B	THR78
B	LYS79
B	MET80
B	ILE81
B	PHE82
B	LEU94

---

site_id	AC4
Number of Residues	13
Details	BINDING SITE FOR RESIDUE DTP C 1301

Chain	Residue
C	VAL125
C	PHE126
C	VAL127
C	GLY159
C	LYS160
C	SER161
C	VAL162
C	ASP244
C	ARG265
C	PRO321
C	SER325
C	TYR359
C	MG1302

---

site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG C 1302

Chain	Residue
C	SER161
C	ASP243
C	DTP1301

---

site_id	AC6
Number of Residues	22
Details	BINDING SITE FOR RESIDUE HEM D 201

Chain	Residue
D	LYS13
D	CYS14
D	CYS17
D	HIS18
D	THR28
D	GLY29
D	PRO30
D	LEU32
D	ARG38
D	THR40
D	GLY41
D	TYR48
D	THR49
D	ASN52
D	TRP59
D	TYR67
D	THR78
D	LYS79
D	MET80
D	ILE81
D	PHE82
D	LEU94

---

site_id	AC7
Number of Residues	13
Details	BINDING SITE FOR RESIDUE DTP E 1301

Chain	Residue
E	VAL125
E	PHE126
E	VAL127
E	GLY159
E	LYS160
E	SER161
E	VAL162
E	ASP244
E	ARG265
E	PRO321
E	SER325
E	TYR359
E	MG1302

---

site_id	AC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG E 1302

Chain	Residue
E	SER161
E	ASP243
E	DTP1301

---

site_id	AC9
Number of Residues	22
Details	BINDING SITE FOR RESIDUE HEM F 201

Chain	Residue
F	LEU32
F	ARG38
F	THR40
F	GLY41
F	TYR48
F	THR49
F	ASN52
F	TRP59
F	TYR67
F	THR78
F	LYS79
F	MET80
F	ILE81
F	PHE82
F	LEU94
F	LYS13
F	CYS14
F	CYS17
F	HIS18
F	THR28
F	GLY29
F	PRO30

---

site_id	BC1
Number of Residues	13
Details	BINDING SITE FOR RESIDUE DTP G 1301

Chain	Residue
G	VAL125
G	PHE126
G	VAL127
G	GLY159
G	LYS160
G	SER161
G	VAL162
G	ASP244
G	ARG265
G	PRO321
G	SER325
G	TYR359
G	MG1302

---

site_id	BC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG G 1302

Chain	Residue
G	SER161
G	ASP243
G	DTP1301

---

site_id	BC3
Number of Residues	22
Details	BINDING SITE FOR RESIDUE HEM H 201

Chain	Residue
H	LYS13
H	CYS14
H	CYS17
H	HIS18
H	THR28
H	GLY29
H	PRO30
H	LEU32
H	ARG38
H	THR40
H	GLY41
H	TYR48
H	THR49
H	ASN52
H	TRP59
H	TYR67
H	THR78
H	LYS79
H	MET80
H	ILE81
H	PHE82
H	LEU94

---

site_id	BC4
Number of Residues	13
Details	BINDING SITE FOR RESIDUE DTP I 1301

Chain	Residue
I	VAL125
I	PHE126
I	VAL127
I	GLY159
I	LYS160
I	SER161
I	VAL162
I	ASP244
I	ARG265
I	PRO321
I	SER325
I	TYR359
I	MG1302

---

site_id	BC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG I 1302

Chain	Residue
I	SER161
I	ASP243
I	DTP1301

---

site_id	BC6
Number of Residues	22
Details	BINDING SITE FOR RESIDUE HEM J 201

Chain	Residue
J	LYS13
J	CYS14
J	CYS17
J	HIS18
J	THR28
J	GLY29
J	PRO30
J	LEU32
J	ARG38
J	THR40
J	GLY41
J	TYR48
J	THR49
J	ASN52
J	TRP59
J	TYR67
J	THR78
J	LYS79
J	MET80
J	ILE81
J	PHE82
J	LEU94

---

site_id	BC7
Number of Residues	13
Details	BINDING SITE FOR RESIDUE DTP K 1301

Chain	Residue
K	VAL125
K	PHE126
K	VAL127
K	GLY159
K	LYS160
K	SER161
K	VAL162
K	ASP244
K	ARG265
K	PRO321
K	SER325
K	TYR359
K	MG1302

---

site_id	BC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG K 1302

Chain	Residue
K	SER161
K	ASP243
K	DTP1301

---

site_id	BC9
Number of Residues	22
Details	BINDING SITE FOR RESIDUE HEM L 201

Chain	Residue
L	LYS13
L	CYS14
L	CYS17
L	HIS18
L	THR28
L	GLY29
L	PRO30
L	LEU32
L	ARG38
L	THR40
L	GLY41
L	TYR48
L	THR49
L	ASN52
L	TRP59
L	TYR67
L	THR78
L	LYS79
L	MET80
L	ILE81
L	PHE82
L	LEU94

---

site_id	CC1
Number of Residues	13
Details	BINDING SITE FOR RESIDUE DTP M 1301

Chain	Residue
M	VAL125
M	PHE126
M	VAL127
M	GLY159
M	LYS160
M	SER161
M	VAL162
M	ASP244
M	ARG265
M	PRO321
M	SER325
M	TYR359
M	MG1302

---

site_id	CC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG M 1302

Chain	Residue
M	SER161
M	ASP243
M	DTP1301

---

site_id	CC3
Number of Residues	22
Details	BINDING SITE FOR RESIDUE HEM N 201

Chain	Residue
N	LYS13
N	CYS14
N	CYS17
N	HIS18
N	THR28
N	GLY29
N	PRO30
N	LEU32
N	ARG38
N	THR40
N	GLY41
N	TYR48
N	THR49
N	ASN52
N	TRP59
N	TYR67
N	THR78
N	LYS79
N	MET80
N	ILE81
N	PHE82
N	LEU94

---

Functional Information from PROSITE/UniProt

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. IATCsvDkKVKIWNS

Chain	Residue	Details
A	ILE672-SER686
A	LEU716-LEU730
A	LEU758-ALA772
A	LEU1142-VAL1156

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	14
Details	BINDING: covalent

Chain	Residue	Details
B	CYS14
J	CYS17
L	CYS14
L	CYS17
N	CYS14
N	CYS17
B	CYS17
D	CYS14
D	CYS17
F	CYS14
F	CYS17
H	CYS14
H	CYS17
J	CYS14

---

site_id	SWS_FT_FI2
Number of Residues	7
Details	BINDING: axial binding residue => ECO:0000255|PROSITE-ProRule:PRU00433, ECO:0000269|PubMed:5545094

Chain	Residue	Details
B	HIS18
D	HIS18
F	HIS18
H	HIS18
J	HIS18
L	HIS18
N	HIS18

---

site_id	SWS_FT_FI3
Number of Residues	7
Details	BINDING: axial binding residue

Chain	Residue	Details
B	MET80
D	MET80
F	MET80
H	MET80
J	MET80
L	MET80
N	MET80

---

site_id	SWS_FT_FI4
Number of Residues	7
Details	MOD_RES: N-acetylglycine => ECO:0000269|PubMed:14469771

Chain	Residue	Details
B	GLY1
D	GLY1
F	GLY1
H	GLY1
J	GLY1
L	GLY1
N	GLY1

---

site_id	SWS_FT_FI5
Number of Residues	14
Details	MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P62894

Chain	Residue	Details
B	TYR48
J	TYR97
L	TYR48
L	TYR97
N	TYR48
N	TYR97
B	TYR97
D	TYR48
D	TYR97
F	TYR48
F	TYR97
H	TYR48
H	TYR97
J	TYR48

---

site_id	SWS_FT_FI6
Number of Residues	7
Details	MOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:P62897

Chain	Residue	Details
B	LYS55
D	LYS55
F	LYS55
H	LYS55
J	LYS55
L	LYS55
N	LYS55

---

site_id	SWS_FT_FI7
Number of Residues	7
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P62897

Chain	Residue	Details
B	LYS72
D	LYS72
F	LYS72
H	LYS72
J	LYS72
L	LYS72
N	LYS72

---

site_id	SWS_FT_FI8
Number of Residues	7
Details	MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P62897

Chain	Residue	Details
B	LYS99
D	LYS99
F	LYS99
H	LYS99
J	LYS99
L	LYS99
N	LYS99

---