Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004190 | molecular_function | aspartic-type endopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
| A | 0016020 | cellular_component | membrane |
| B | 0004190 | molecular_function | aspartic-type endopeptidase activity |
| B | 0006508 | biological_process | proteolysis |
| B | 0016020 | cellular_component | membrane |
| C | 0004190 | molecular_function | aspartic-type endopeptidase activity |
| C | 0006508 | biological_process | proteolysis |
| C | 0016020 | cellular_component | membrane |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 28 |
| Details | BINDING SITE FOR RESIDUE 586 A 500 |
| Chain | Residue |
| A | GLY59 |
| A | THR120 |
| A | GLN121 |
| A | GLY122 |
| A | PHE156 |
| A | ILE158 |
| A | ILE174 |
| A | TYR246 |
| A | ILE274 |
| A | ASP276 |
| A | SER277 |
| A | GLN60 |
| A | GLY278 |
| A | THR279 |
| A | THR280 |
| A | ASN281 |
| A | ARG283 |
| A | SER373 |
| A | ALA383 |
| A | HOH709 |
| A | HOH736 |
| A | GLY61 |
| A | ASP80 |
| A | GLY82 |
| A | SER83 |
| A | VAL117 |
| A | PRO118 |
| A | TYR119 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 700 |
| Chain | Residue |
| A | ARG283 |
| A | SER375 |
| A | SER376 |
| A | HOH732 |
| site_id | AC3 |
| Number of Residues | 28 |
| Details | BINDING SITE FOR RESIDUE 586 B 500 |
| Chain | Residue |
| B | GLY59 |
| B | GLN60 |
| B | GLY61 |
| B | ASP80 |
| B | GLY82 |
| B | SER83 |
| B | VAL117 |
| B | PRO118 |
| B | TYR119 |
| B | THR120 |
| B | GLN121 |
| B | GLY122 |
| B | PHE156 |
| B | ILE158 |
| B | ILE174 |
| B | TYR246 |
| B | ILE274 |
| B | ASP276 |
| B | SER277 |
| B | GLY278 |
| B | THR279 |
| B | THR280 |
| B | ASN281 |
| B | ARG283 |
| B | SER373 |
| B | ALA383 |
| B | HOH738 |
| B | HOH785 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 B 700 |
| Chain | Residue |
| B | ARG283 |
| B | SER375 |
| B | SER376 |
| site_id | AC5 |
| Number of Residues | 27 |
| Details | BINDING SITE FOR RESIDUE 586 C 500 |
| Chain | Residue |
| C | GLY59 |
| C | GLN60 |
| C | GLY61 |
| C | LEU78 |
| C | ASP80 |
| C | GLY82 |
| C | VAL117 |
| C | PRO118 |
| C | TYR119 |
| C | THR120 |
| C | GLN121 |
| C | GLY122 |
| C | PHE156 |
| C | ILE158 |
| C | TYR246 |
| C | ASP276 |
| C | SER277 |
| C | GLY278 |
| C | THR279 |
| C | THR280 |
| C | ASN281 |
| C | ARG283 |
| C | SER373 |
| C | ALA383 |
| C | HOH729 |
| C | HOH731 |
| C | HOH769 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 C 700 |
| Chain | Residue |
| C | ARG283 |
| C | GLN374 |
| C | SER376 |
Functional Information from PROSITE/UniProt
| site_id | PS00141 |
| Number of Residues | 12 |
| Details | ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. ILVDTGSSNFAV |
| Chain | Residue | Details |
| A | ILE77-VAL88 | |
Functional Information from SwissProt/UniProt
| Chain | Residue | Details |
| A | ASP80 | |
| A | ASP276 | |
| B | ASP80 | |
| B | ASP276 | |
| C | ASP80 | |
| C | ASP276 | |
| Chain | Residue | Details |
| A | LYS113 | |
| A | LYS262 | |
| A | LYS266 | |
| A | LYS272 | |
| A | LYS286 | |
| A | LYS287 | |
| A | LYS294 | |
| B | LYS113 | |
| B | LYS262 | |
| B | LYS266 | |
| B | LYS272 | |
| B | LYS286 | |
| B | LYS287 | |
| B | LYS294 | |
| C | LYS113 | |
| C | LYS262 | |
| C | LYS266 | |
| C | LYS272 | |
| C | LYS286 | |
| C | LYS287 | |
| C | LYS294 | |
| site_id | SWS_FT_FI3 |
| Number of Residues | 12 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN140 | |
| A | ASN159 | |
| A | ASN210 | |
| A | ASN341 | |
| B | ASN140 | |
| B | ASN159 | |
| B | ASN210 | |
| B | ASN341 | |
| C | ASN140 | |
| C | ASN159 | |
| C | ASN210 | |
| C | ASN341 | |
