3IQE
Structure of F420 dependent methylene-tetrahydromethanopterin dehydrogenase in complex with methylene-tetrahydromethanopterin and coenzyme F420
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0006730 | biological_process | one-carbon metabolic process |
| A | 0008901 | molecular_function | ferredoxin hydrogenase activity |
| A | 0015948 | biological_process | methanogenesis |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0019386 | biological_process | methanogenesis, from carbon dioxide |
| A | 0030268 | molecular_function | methylenetetrahydromethanopterin dehydrogenase activity |
| B | 0006730 | biological_process | one-carbon metabolic process |
| B | 0008901 | molecular_function | ferredoxin hydrogenase activity |
| B | 0015948 | biological_process | methanogenesis |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0019386 | biological_process | methanogenesis, from carbon dioxide |
| B | 0030268 | molecular_function | methylenetetrahydromethanopterin dehydrogenase activity |
| C | 0006730 | biological_process | one-carbon metabolic process |
| C | 0008901 | molecular_function | ferredoxin hydrogenase activity |
| C | 0015948 | biological_process | methanogenesis |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0019386 | biological_process | methanogenesis, from carbon dioxide |
| C | 0030268 | molecular_function | methylenetetrahydromethanopterin dehydrogenase activity |
| D | 0006730 | biological_process | one-carbon metabolic process |
| D | 0008901 | molecular_function | ferredoxin hydrogenase activity |
| D | 0015948 | biological_process | methanogenesis |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0019386 | biological_process | methanogenesis, from carbon dioxide |
| D | 0030268 | molecular_function | methylenetetrahydromethanopterin dehydrogenase activity |
| E | 0006730 | biological_process | one-carbon metabolic process |
| E | 0008901 | molecular_function | ferredoxin hydrogenase activity |
| E | 0015948 | biological_process | methanogenesis |
| E | 0016491 | molecular_function | oxidoreductase activity |
| E | 0019386 | biological_process | methanogenesis, from carbon dioxide |
| E | 0030268 | molecular_function | methylenetetrahydromethanopterin dehydrogenase activity |
| F | 0006730 | biological_process | one-carbon metabolic process |
| F | 0008901 | molecular_function | ferredoxin hydrogenase activity |
| F | 0015948 | biological_process | methanogenesis |
| F | 0016491 | molecular_function | oxidoreductase activity |
| F | 0019386 | biological_process | methanogenesis, from carbon dioxide |
| F | 0030268 | molecular_function | methylenetetrahydromethanopterin dehydrogenase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE H4M A 284 |
| Chain | Residue |
| A | ASN13 |
| A | ASN141 |
| A | CYS221 |
| A | TYR230 |
| A | F42285 |
| A | HOH390 |
| D | GLU26 |
| D | ARG27 |
| A | GLY15 |
| A | MET124 |
| A | LEU125 |
| A | ALA127 |
| A | ARG128 |
| A | ARG129 |
| A | GLU130 |
| A | MET137 |
| site_id | AC2 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE F42 A 285 |
| Chain | Residue |
| A | GLY12 |
| A | ASN13 |
| A | LEU14 |
| A | VAL42 |
| A | MET44 |
| A | PRO73 |
| A | ASN74 |
| A | ASP99 |
| A | PHE222 |
| A | H4M284 |
| A | HOH293 |
| A | HOH544 |
| site_id | AC3 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE H4M B 284 |
| Chain | Residue |
| B | ASN13 |
| B | GLY15 |
| B | MET124 |
| B | LEU125 |
| B | ALA127 |
| B | ARG128 |
| B | ARG129 |
| B | GLU130 |
| B | MET137 |
| B | ASN141 |
| B | CYS221 |
| B | TYR230 |
| B | F42285 |
| B | HOH307 |
| B | HOH601 |
| F | GLU26 |
| F | ARG27 |
| F | HOH414 |
| site_id | AC4 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE F42 B 285 |
| Chain | Residue |
| B | GLY12 |
| B | ASN13 |
| B | VAL42 |
| B | MET44 |
| B | PRO73 |
| B | ASN74 |
| B | ASP99 |
| B | PRO101 |
| B | MET124 |
| B | PHE222 |
| B | H4M284 |
| B | HOH330 |
| B | HOH698 |
| B | HOH711 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CA B 286 |
| Chain | Residue |
| B | GLU85 |
| B | ASP89 |
| E | GLU47 |
| E | GLU50 |
| site_id | AC6 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CA B 287 |
| Chain | Residue |
| B | GLU34 |
| B | ARG36 |
| site_id | AC7 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE H4M C 284 |
| Chain | Residue |
| C | ASN13 |
| C | LEU14 |
| C | GLY15 |
| C | VAL42 |
| C | MET124 |
| C | LEU125 |
| C | ALA127 |
| C | ARG128 |
| C | ARG129 |
| C | GLU130 |
| C | ASN141 |
| C | CYS221 |
| C | TYR230 |
| C | F42285 |
| C | HOH305 |
| C | HOH437 |
| E | GLU26 |
| E | ARG27 |
| E | HOH330 |
| site_id | AC8 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE F42 C 285 |
| Chain | Residue |
| C | GLY12 |
| C | ASN13 |
| C | VAL42 |
| C | MET44 |
| C | PRO73 |
| C | ASN74 |
| C | ASP99 |
| C | PRO101 |
| C | MET124 |
| C | PHE222 |
| C | H4M284 |
| C | HOH406 |
| C | HOH508 |
| E | ALA28 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CA C 286 |
| Chain | Residue |
| C | GLU228 |
| C | ASP269 |
| E | HOH751 |
| E | HOH757 |
| site_id | BC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE NA C 287 |
| Chain | Residue |
| C | ASP215 |
| C | HOH607 |
| site_id | BC2 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE H4M D 284 |
| Chain | Residue |
| A | GLU26 |
| A | ARG27 |
| A | ALA28 |
| D | ASN13 |
| D | GLY15 |
| D | MET124 |
| D | LEU125 |
| D | ALA127 |
| D | ARG128 |
| D | ARG129 |
| D | GLU130 |
| D | MET137 |
| D | ASN141 |
| D | CYS221 |
| D | TYR230 |
| D | F42285 |
| D | HOH300 |
| D | HOH493 |
| D | HOH622 |
| site_id | BC3 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE F42 D 285 |
| Chain | Residue |
| A | ALA28 |
| D | GLY12 |
| D | ASN13 |
| D | LEU14 |
| D | VAL42 |
| D | MET44 |
| D | PRO73 |
| D | ASN74 |
| D | ASP99 |
| D | MET124 |
| D | PHE222 |
| D | H4M284 |
| D | HOH332 |
| D | HOH773 |
| site_id | BC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CA D 286 |
| Chain | Residue |
| D | GLU50 |
| D | GLU54 |
| D | HOH714 |
| site_id | BC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA D 287 |
| Chain | Residue |
| D | ASP25 |
| D | GLU26 |
| D | ARG27 |
| D | ALA28 |
| D | ASP29 |
| site_id | BC6 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE H4M E 284 |
| Chain | Residue |
| C | GLU26 |
| C | ARG27 |
| C | ALA28 |
| C | HOH338 |
| E | ASN13 |
| E | GLY15 |
| E | VAL42 |
| E | MET124 |
| E | LEU125 |
| E | ALA127 |
| E | ARG128 |
| E | ARG129 |
| E | GLU130 |
| E | MET137 |
| E | ASN141 |
| E | CYS221 |
| E | TYR230 |
| E | F42285 |
| E | HOH315 |
| site_id | BC7 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE F42 E 285 |
| Chain | Residue |
| C | ALA28 |
| E | GLY12 |
| E | ASN13 |
| E | LEU14 |
| E | VAL42 |
| E | MET44 |
| E | PRO73 |
| E | ASN74 |
| E | ASP99 |
| E | H4M284 |
| E | HOH296 |
| site_id | BC8 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE NA E 286 |
| Chain | Residue |
| E | ASP66 |
| site_id | BC9 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE H4M F 284 |
| Chain | Residue |
| B | GLU26 |
| B | ARG27 |
| B | ALA28 |
| B | HOH326 |
| F | ASN13 |
| F | GLY15 |
| F | MET124 |
| F | LEU125 |
| F | ALA127 |
| F | ARG128 |
| F | ARG129 |
| F | GLU130 |
| F | ASN141 |
| F | LEU144 |
| F | CYS221 |
| F | PHE222 |
| F | TYR230 |
| F | F42285 |
| F | HOH289 |
| F | HOH316 |
| F | HOH737 |
| site_id | CC1 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE F42 F 285 |
| Chain | Residue |
| B | ALA28 |
| F | GLY12 |
| F | ASN13 |
| F | LEU14 |
| F | VAL42 |
| F | MET44 |
| F | PRO73 |
| F | ASN74 |
| F | ASP99 |
| F | MET124 |
| F | PHE222 |
| F | H4M284 |
| F | HOH393 |
| F | HOH439 |
| F | HOH550 |
| F | HOH730 |
| F | HOH741 |
