3I9J
Crystal structure of ADP ribosyl cyclase complexed with a substrate analog and a product nicotinamide
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0003953 | molecular_function | NAD+ nucleosidase activity |
A | 0005886 | cellular_component | plasma membrane |
A | 0007338 | biological_process | single fertilization |
A | 0016020 | cellular_component | membrane |
A | 0016740 | molecular_function | transferase activity |
A | 0016787 | molecular_function | hydrolase activity |
A | 0016849 | molecular_function | phosphorus-oxygen lyase activity |
A | 0030890 | biological_process | positive regulation of B cell proliferation |
A | 0031410 | cellular_component | cytoplasmic vesicle |
A | 0061809 | molecular_function | NAD+ nucleotidase, cyclic ADP-ribose generating |
B | 0003953 | molecular_function | NAD+ nucleosidase activity |
B | 0005886 | cellular_component | plasma membrane |
B | 0007338 | biological_process | single fertilization |
B | 0016020 | cellular_component | membrane |
B | 0016740 | molecular_function | transferase activity |
B | 0016787 | molecular_function | hydrolase activity |
B | 0016849 | molecular_function | phosphorus-oxygen lyase activity |
B | 0030890 | biological_process | positive regulation of B cell proliferation |
B | 0031410 | cellular_component | cytoplasmic vesicle |
B | 0061809 | molecular_function | NAD+ nucleotidase, cyclic ADP-ribose generating |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE NFD A 301 |
Chain | Residue |
A | PHE76 |
A | PHE174 |
A | PHE175 |
A | GLU179 |
A | HOH279 |
A | TRP77 |
A | SER78 |
A | GLY79 |
A | LEU97 |
A | GLU98 |
A | TRP140 |
A | SER144 |
A | SER173 |
site_id | AC2 |
Number of Residues | 14 |
Details | BINDING SITE FOR RESIDUE AVV B 301 |
Chain | Residue |
B | PHE76 |
B | TRP77 |
B | SER78 |
B | GLY79 |
B | ARG136 |
B | TRP140 |
B | SER144 |
B | ARG170 |
B | SER173 |
B | PHE174 |
B | PHE175 |
B | GLU179 |
B | HOH273 |
B | NCA302 |
site_id | AC3 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE NCA B 302 |
Chain | Residue |
B | GLU98 |
B | ASN107 |
B | TRP140 |
B | PHE174 |
B | AVV301 |
Catalytic Information from CSA
site_id | MCSA1 |
Number of Residues | 3 |
Details | M-CSA 607 |
Chain | Residue | Details |
A | GLU98 | electrostatic stabiliser |
A | PHE174 | hydrophobic interaction |
A | GLU179 | covalent catalysis, covalently attached, nucleophile |
site_id | MCSA2 |
Number of Residues | 3 |
Details | M-CSA 607 |
Chain | Residue | Details |
B | GLU98 | electrostatic stabiliser |
B | PHE174 | hydrophobic interaction |
B | GLU179 | covalent catalysis, covalently attached, nucleophile |