Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003723 | molecular_function | RNA binding |
| A | 0003743 | molecular_function | translation initiation factor activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006413 | biological_process | translational initiation |
| C | 0008190 | molecular_function | eukaryotic initiation factor 4E binding |
| C | 0045947 | biological_process | negative regulation of translational initiation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 24 |
| Details | BINDING SITE FOR RESIDUE GTG A 501 |
| Chain | Residue |
| A | HOH8 |
| A | ASP84 |
| A | LYS88 |
| A | TRP89 |
| A | GLU90 |
| A | GLN141 |
| A | ARG143 |
| A | LYS148 |
| A | ARG192 |
| A | HOH208 |
| A | HOH223 |
| A | GLU21 |
| A | HOH224 |
| A | HOH238 |
| A | HOH252 |
| A | HOH256 |
| A | HOH276 |
| A | PHE22 |
| A | PHE35 |
| A | PHE37 |
| A | LEU41 |
| A | ASP42 |
| A | TRP43 |
| A | GLY75 |
Functional Information from PROSITE/UniProt
| site_id | PS00813 |
| Number of Residues | 24 |
| Details | IF4E Eukaryotic initiation factor 4E signature. DLymFKsdImPkWEDpknenGGRW |
| Chain | Residue | Details |
| A | ASP77-TRP100 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine; by DYRK2, MAPK1, MAPK3 and MTOR => ECO:0000269|PubMed:12588975, ECO:0000269|PubMed:12747827, ECO:0000269|PubMed:22578813, ECO:0000269|PubMed:25702871, ECO:0000269|PubMed:29750193, ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| C | SER19 | |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000305|PubMed:22578813 |
| Chain | Residue | Details |
| C | LYS11 | |
