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3HQW

Discovery of novel inhibitors of PDE10A

Functional Information from GO Data
ChainGOidnamespacecontents
A0004114molecular_function3',5'-cyclic-nucleotide phosphodiesterase activity
A0007165biological_processsignal transduction
A0008081molecular_functionphosphoric diester hydrolase activity
Functional Information from PDB Data
site_idAC1
Number of Residues5
DetailsBINDING SITE FOR RESIDUE ZN A 1
ChainResidue
AHIS519
AHIS553
AASP554
AASP664
AHOH938

site_idAC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE MG A 2
ChainResidue
AASP554
AHOH805
AHOH920
AHOH938

site_idAC3
Number of Residues13
DetailsBINDING SITE FOR RESIDUE PF4 A 999
ChainResidue
AHOH26
AHIS647
AVAL668
AILE682
ATYR683
AMET703
ALYS708
AGLY715
AGLN716
APHE719
AVAL723
AHOH937
AHOH945

Functional Information from PROSITE/UniProt
site_idPS00126
Number of Residues12
DetailsPDEASE_I_1 3'5'-cyclic nucleotide phosphodiesterase domain signature. HDLdHrGfsNsY
ChainResidueDetails
AHIS553-TYR564

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsACT_SITE: Proton donor => ECO:0000250|UniProtKB:O76083
ChainResidueDetails
AHIS515

site_idSWS_FT_FI2
Number of Residues2
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:Q9Y233
ChainResidueDetails
AHIS515
AGLN716

site_idSWS_FT_FI3
Number of Residues4
DetailsBINDING: BINDING => ECO:0000269|PubMed:17228859
ChainResidueDetails
AHIS553
AASP554
AASP664
AHIS519

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PDB entries from 2024-06-12

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