3GZD

Human selenocysteine lyase, P1 crystal form

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005794	cellular_component	Golgi apparatus
A	0005829	cellular_component	cytosol
A	0006520	biological_process	amino acid metabolic process
A	0009000	molecular_function	selenocysteine lyase activity
A	0016261	biological_process	selenocysteine catabolic process
A	0016597	molecular_function	amino acid binding
A	0016740	molecular_function	transferase activity
A	0016829	molecular_function	lyase activity
A	0042803	molecular_function	protein homodimerization activity
A	0070279	molecular_function	vitamin B6 binding
A	1902494	cellular_component	catalytic complex
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005794	cellular_component	Golgi apparatus
B	0005829	cellular_component	cytosol
B	0006520	biological_process	amino acid metabolic process
B	0009000	molecular_function	selenocysteine lyase activity
B	0016261	biological_process	selenocysteine catabolic process
B	0016597	molecular_function	amino acid binding
B	0016740	molecular_function	transferase activity
B	0016829	molecular_function	lyase activity
B	0042803	molecular_function	protein homodimerization activity
B	0070279	molecular_function	vitamin B6 binding
B	1902494	cellular_component	catalytic complex
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005794	cellular_component	Golgi apparatus
C	0005829	cellular_component	cytosol
C	0006520	biological_process	amino acid metabolic process
C	0009000	molecular_function	selenocysteine lyase activity
C	0016261	biological_process	selenocysteine catabolic process
C	0016597	molecular_function	amino acid binding
C	0016740	molecular_function	transferase activity
C	0016829	molecular_function	lyase activity
C	0042803	molecular_function	protein homodimerization activity
C	0070279	molecular_function	vitamin B6 binding
C	1902494	cellular_component	catalytic complex
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005794	cellular_component	Golgi apparatus
D	0005829	cellular_component	cytosol
D	0006520	biological_process	amino acid metabolic process
D	0009000	molecular_function	selenocysteine lyase activity
D	0016261	biological_process	selenocysteine catabolic process
D	0016597	molecular_function	amino acid binding
D	0016740	molecular_function	transferase activity
D	0016829	molecular_function	lyase activity
D	0042803	molecular_function	protein homodimerization activity
D	0070279	molecular_function	vitamin B6 binding
D	1902494	cellular_component	catalytic complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	16
Details	BINDING SITE FOR RESIDUE PLR A 500

Chain	Residue
A	GLY99
A	HIS258
A	LYS259
A	HOH457
A	HOH462
A	HOH504
A	NO3600
B	THR296
A	THR100
A	HIS145
A	MET194
A	ASN198
A	ASP233
A	ALA235
A	GLN236
A	VAL256

---

site_id	AC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE NO3 A 600

Chain	Residue
A	ASN37
A	ALA38
A	ASN198
A	LYS259
A	ALA386
A	ALA387
A	CSS388
A	ARG415
A	PLR500

---

site_id	AC3
Number of Residues	16
Details	BINDING SITE FOR RESIDUE PLR B 500

Chain	Residue
A	GLY295
A	THR296
B	GLY99
B	THR100
B	HIS145
B	MET194
B	ASP233
B	ALA235
B	GLN236
B	VAL256
B	HIS258
B	LYS259
B	HOH452
B	HOH473
B	HOH497
B	NO3600

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NO3 B 600

Chain	Residue
B	ASN37
B	ALA38
B	ASN198
B	LYS259
B	ARG415
B	PLR500

---

site_id	AC5
Number of Residues	15
Details	BINDING SITE FOR RESIDUE PLR C 500

Chain	Residue
C	GLY99
C	THR100
C	HIS145
C	MET194
C	ASP233
C	ALA235
C	GLN236
C	VAL256
C	HIS258
C	LYS259
C	HOH476
C	HOH486
C	HOH592
C	NO3600
D	THR296

---

site_id	AC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE NO3 C 600

Chain	Residue
C	ASN37
C	ALA38
C	ASN198
C	ALA386
C	ALA387
C	ARG415
C	PLR500

---

site_id	AC7
Number of Residues	14
Details	BINDING SITE FOR RESIDUE PLR D 500

Chain	Residue
C	THR296
D	GLY99
D	THR100
D	HIS145
D	MET194
D	ASP233
D	ALA235
D	GLN236
D	VAL256
D	HIS258
D	LYS259
D	HOH461
D	HOH468
D	HOH499

---

site_id	AC8
Number of Residues	7
Details	BINDING SITE FOR RESIDUE NO3 D 600

Chain	Residue
D	ASN37
D	ALA38
D	ASN198
D	ALA386
D	ALA387
D	CSS388
D	ARG415

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: S-selanylcysteine intermediate => ECO:0000250|UniProtKB:Q68FT9

Chain	Residue	Details
C	CYS388
B	CSS388
D	CSS388

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231

Chain	Residue	Details
C	SER129
B	SER129
D	SER129

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: N6-(pyridoxal phosphate)lysine => ECO:0000269|Ref.12

Chain	Residue	Details
C	LYS259
B	LYS259
D	LYS259

---