Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3GQR

Crystal structure determination of cat (Felis silvestris catus) hemoglobin at 2.4 angstrom resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004601	molecular_function	peroxidase activity
A	0005344	molecular_function	oxygen carrier activity
A	0005506	molecular_function	iron ion binding
A	0005833	cellular_component	hemoglobin complex
A	0015671	biological_process	oxygen transport
A	0019825	molecular_function	oxygen binding
A	0020037	molecular_function	heme binding
A	0031720	molecular_function	haptoglobin binding
A	0031838	cellular_component	haptoglobin-hemoglobin complex
A	0042744	biological_process	hydrogen peroxide catabolic process
A	0043177	molecular_function	organic acid binding
A	0046872	molecular_function	metal ion binding
A	0098869	biological_process	cellular oxidant detoxification
B	0004601	molecular_function	peroxidase activity
B	0005344	molecular_function	oxygen carrier activity
B	0005833	cellular_component	hemoglobin complex
B	0015671	biological_process	oxygen transport
B	0019825	molecular_function	oxygen binding
B	0020037	molecular_function	heme binding
B	0031720	molecular_function	haptoglobin binding
B	0031721	molecular_function	hemoglobin alpha binding
B	0031838	cellular_component	haptoglobin-hemoglobin complex
B	0042744	biological_process	hydrogen peroxide catabolic process
B	0043177	molecular_function	organic acid binding
B	0046872	molecular_function	metal ion binding
B	0098869	biological_process	cellular oxidant detoxification
C	0004601	molecular_function	peroxidase activity
C	0005344	molecular_function	oxygen carrier activity
C	0005506	molecular_function	iron ion binding
C	0005833	cellular_component	hemoglobin complex
C	0015671	biological_process	oxygen transport
C	0019825	molecular_function	oxygen binding
C	0020037	molecular_function	heme binding
C	0031720	molecular_function	haptoglobin binding
C	0031838	cellular_component	haptoglobin-hemoglobin complex
C	0042744	biological_process	hydrogen peroxide catabolic process
C	0043177	molecular_function	organic acid binding
C	0046872	molecular_function	metal ion binding
C	0098869	biological_process	cellular oxidant detoxification
D	0004601	molecular_function	peroxidase activity
D	0005344	molecular_function	oxygen carrier activity
D	0005833	cellular_component	hemoglobin complex
D	0015671	biological_process	oxygen transport
D	0019825	molecular_function	oxygen binding
D	0020037	molecular_function	heme binding
D	0031720	molecular_function	haptoglobin binding
D	0031721	molecular_function	hemoglobin alpha binding
D	0031838	cellular_component	haptoglobin-hemoglobin complex
D	0042744	biological_process	hydrogen peroxide catabolic process
D	0043177	molecular_function	organic acid binding
D	0046872	molecular_function	metal ion binding
D	0098869	biological_process	cellular oxidant detoxification
E	0004601	molecular_function	peroxidase activity
E	0005344	molecular_function	oxygen carrier activity
E	0005506	molecular_function	iron ion binding
E	0005833	cellular_component	hemoglobin complex
E	0015671	biological_process	oxygen transport
E	0019825	molecular_function	oxygen binding
E	0020037	molecular_function	heme binding
E	0031720	molecular_function	haptoglobin binding
E	0031838	cellular_component	haptoglobin-hemoglobin complex
E	0042744	biological_process	hydrogen peroxide catabolic process
E	0043177	molecular_function	organic acid binding
E	0046872	molecular_function	metal ion binding
E	0098869	biological_process	cellular oxidant detoxification
F	0004601	molecular_function	peroxidase activity
F	0005344	molecular_function	oxygen carrier activity
F	0005833	cellular_component	hemoglobin complex
F	0015671	biological_process	oxygen transport
F	0019825	molecular_function	oxygen binding
F	0020037	molecular_function	heme binding
F	0031720	molecular_function	haptoglobin binding
F	0031721	molecular_function	hemoglobin alpha binding
F	0031838	cellular_component	haptoglobin-hemoglobin complex
F	0042744	biological_process	hydrogen peroxide catabolic process
F	0043177	molecular_function	organic acid binding
F	0046872	molecular_function	metal ion binding
F	0098869	biological_process	cellular oxidant detoxification
G	0004601	molecular_function	peroxidase activity
G	0005344	molecular_function	oxygen carrier activity
G	0005506	molecular_function	iron ion binding
G	0005833	cellular_component	hemoglobin complex
G	0015671	biological_process	oxygen transport
G	0019825	molecular_function	oxygen binding
G	0020037	molecular_function	heme binding
G	0031720	molecular_function	haptoglobin binding
G	0031838	cellular_component	haptoglobin-hemoglobin complex
G	0042744	biological_process	hydrogen peroxide catabolic process
G	0043177	molecular_function	organic acid binding
G	0046872	molecular_function	metal ion binding
G	0098869	biological_process	cellular oxidant detoxification
H	0004601	molecular_function	peroxidase activity
H	0005344	molecular_function	oxygen carrier activity
H	0005833	cellular_component	hemoglobin complex
H	0015671	biological_process	oxygen transport
H	0019825	molecular_function	oxygen binding
H	0020037	molecular_function	heme binding
H	0031720	molecular_function	haptoglobin binding
H	0031721	molecular_function	hemoglobin alpha binding
H	0031838	cellular_component	haptoglobin-hemoglobin complex
H	0042744	biological_process	hydrogen peroxide catabolic process
H	0043177	molecular_function	organic acid binding
H	0046872	molecular_function	metal ion binding
H	0098869	biological_process	cellular oxidant detoxification

Functional Information from PDB Data

site_id	AC1
Number of Residues	15
Details	BINDING SITE FOR RESIDUE HEM A 143

Chain	Residue
A	TYR42
A	VAL93
A	ASN97
A	PHE98
A	LEU101
A	LEU136
A	HOH145
A	PHE43
A	PHE46
A	HIS58
A	LYS61
A	LEU83
A	LEU86
A	HIS87
A	LEU91

site_id	AC2
Number of Residues	16
Details	BINDING SITE FOR RESIDUE HEM B 148

Chain	Residue
B	THR38
B	PHE41
B	PHE42
B	PHE45
B	HIS63
B	LYS66
B	SER70
B	PHE71
B	HIS92
B	LEU96
B	ASN102
B	PHE103
B	LEU106
B	LEU141
B	HOH151
B	HOH211

site_id	AC3
Number of Residues	14
Details	BINDING SITE FOR RESIDUE HEM C 143

Chain	Residue
C	TYR42
C	PHE43
C	HIS45
C	HIS58
C	LYS61
C	LEU86
C	HIS87
C	LEU91
C	VAL93
C	ASN97
C	PHE98
C	LEU101
C	LEU136
C	HOH156

site_id	AC4
Number of Residues	12
Details	BINDING SITE FOR RESIDUE HEM D 148

Chain	Residue
D	PHE41
D	PHE42
D	PHE45
D	HIS63
D	SER70
D	HIS92
D	LEU96
D	ASN102
D	PHE103
D	LEU106
D	LEU141
D	HOH162

site_id	AC5
Number of Residues	16
Details	BINDING SITE FOR RESIDUE HEM E 143

Chain	Residue
E	TYR42
E	PHE43
E	PHE46
E	HIS58
E	LYS61
E	LEU66
E	LEU83
E	LEU86
E	HIS87
E	LEU91
E	VAL93
E	ASN97
E	PHE98
E	LEU101
E	LEU136
E	HOH146

site_id	AC6
Number of Residues	11
Details	BINDING SITE FOR RESIDUE HEM F 148

Chain	Residue
F	PHE41
F	HIS63
F	LYS66
F	VAL67
F	SER70
F	HIS92
F	LEU96
F	ASN102
F	PHE103
F	LEU106
F	LEU141

site_id	AC7
Number of Residues	14
Details	BINDING SITE FOR RESIDUE HEM G 143

Chain	Residue
G	THR39
G	TYR42
G	HIS58
G	LYS61
G	LEU83
G	LEU86
G	HIS87
G	LEU91
G	VAL93
G	ASN97
G	PHE98
G	LEU101
G	LEU136
G	HOH178

site_id	AC8
Number of Residues	13
Details	BINDING SITE FOR RESIDUE HEM H 148

Chain	Residue
H	PHE42
H	HIS63
H	LYS66
H	SER70
H	PHE71
H	HIS92
H	LEU96
H	ASN102
H	PHE103
H	LEU106
H	LEU141
H	HOH160
H	PHE41

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	BINDING: distal binding residue

Chain	Residue	Details
B	HIS63
D	HIS63
F	HIS63
H	HIS63

site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: proximal binding residue

Chain	Residue	Details
B	HIS92
D	HIS92
F	HIS92
H	HIS92

site_id	SWS_FT_FI3
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:P68871

Chain	Residue	Details
B	SER44
D	SER44
F	SER44
H	SER44
C	SER35
C	SER49
E	SER3
E	SER35
E	SER49
G	SER3
G	SER35
G	SER49

site_id	SWS_FT_FI4
Number of Residues	12
Details	MOD_RES: N6-acetyllysine => ECO:0000250\|UniProtKB:P68871

Chain	Residue	Details
B	LYS59
B	LYS82
B	LYS144
D	LYS59
D	LYS82
D	LYS144
F	LYS59
F	LYS82
F	LYS144
H	LYS59
H	LYS82
H	LYS144

site_id	SWS_FT_FI5
Number of Residues	4
Details	MOD_RES: S-nitrosocysteine => ECO:0000250\|UniProtKB:P68871

Chain	Residue	Details
B	CYS93
D	CYS93
F	CYS93
H	CYS93

site_id	SWS_FT_FI6
Number of Residues	4
Details	MOD_RES: Phosphotyrosine => ECO:0000250\|UniProtKB:P69905

Chain	Residue	Details
A	TYR24
C	TYR24
E	TYR24
G	TYR24

site_id	SWS_FT_FI7
Number of Residues	12
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:P01942

Chain	Residue	Details
A	SER102
A	SER124
A	SER138
C	SER102
E	SER102
E	SER124
E	SER138
G	SER102
G	SER124
G	SER138
C	SER124
C	SER138

site_id	SWS_FT_FI8
Number of Residues	12
Details	MOD_RES: Phosphothreonine => ECO:0000250\|UniProtKB:P01942

Chain	Residue	Details
A	THR108
A	THR134
A	THR137
C	THR108
C	THR134
C	THR137
E	THR108
E	THR134
E	THR137
G	THR108
G	THR134
G	THR137

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)