3GP0
Crystal Structure of Human Mitogen Activated Protein Kinase 11 (p38 beta) in complex with Nilotinib
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000165 | biological_process | MAPK cascade |
A | 0000166 | molecular_function | nucleotide binding |
A | 0001649 | biological_process | osteoblast differentiation |
A | 0004672 | molecular_function | protein kinase activity |
A | 0004674 | molecular_function | protein serine/threonine kinase activity |
A | 0004707 | molecular_function | MAP kinase activity |
A | 0005515 | molecular_function | protein binding |
A | 0005524 | molecular_function | ATP binding |
A | 0005634 | cellular_component | nucleus |
A | 0005654 | cellular_component | nucleoplasm |
A | 0005737 | cellular_component | cytoplasm |
A | 0005829 | cellular_component | cytosol |
A | 0006468 | biological_process | protein phosphorylation |
A | 0010628 | biological_process | positive regulation of gene expression |
A | 0016301 | molecular_function | kinase activity |
A | 0016310 | biological_process | phosphorylation |
A | 0016740 | molecular_function | transferase activity |
A | 0031098 | biological_process | stress-activated protein kinase signaling cascade |
A | 0032735 | biological_process | positive regulation of interleukin-12 production |
A | 0033554 | biological_process | cellular response to stress |
A | 0035556 | biological_process | intracellular signal transduction |
A | 0038066 | biological_process | p38MAPK cascade |
A | 0045648 | biological_process | positive regulation of erythrocyte differentiation |
A | 0051149 | biological_process | positive regulation of muscle cell differentiation |
A | 0051403 | biological_process | stress-activated MAPK cascade |
A | 0060038 | biological_process | cardiac muscle cell proliferation |
A | 0060043 | biological_process | regulation of cardiac muscle cell proliferation |
A | 0060044 | biological_process | negative regulation of cardiac muscle cell proliferation |
A | 0060348 | biological_process | bone development |
A | 0071347 | biological_process | cellular response to interleukin-1 |
A | 0071493 | biological_process | cellular response to UV-B |
A | 0090398 | biological_process | cellular senescence |
A | 0098586 | biological_process | cellular response to virus |
A | 0106310 | molecular_function | protein serine kinase activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE NIL A 1 |
Chain | Residue |
A | ALA51 |
A | LEU167 |
A | ASP168 |
A | PHE169 |
A | HOH441 |
A | LYS53 |
A | ARG67 |
A | GLU71 |
A | VAL83 |
A | ILE84 |
A | THR106 |
A | MET109 |
A | HIS148 |
site_id | AC2 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE EDO A 351 |
Chain | Residue |
A | GLN22 |
A | GLN25 |
A | ARG73 |
A | ASP324 |
A | HOH390 |
A | HOH518 |
site_id | AC3 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE CL A 352 |
Chain | Residue |
A | ARG23 |
A | ARG45 |
A | ASP88 |
A | HOH542 |
Functional Information from PROSITE/UniProt
site_id | PS00107 |
Number of Residues | 25 |
Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. VGSGAYGSVCsAydarlrqkv.........AVKK |
Chain | Residue | Details |
A | VAL30-LYS54 |
site_id | PS01351 |
Number of Residues | 104 |
Details | MAPK MAP kinase signature. FqsliharrtyRElrllkhlkhenviglldvftpatsiedfsevylvttlmgadlnnivkcqalsdehvqflvyqllrglkyihsagiih.........RDlKpsnvavnedC |
Chain | Residue | Details |
A | PHE59-CYS162 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 1 |
Details | ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159 |
Chain | Residue | Details |
A | ASP150 |
site_id | SWS_FT_FI2 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 |
Chain | Residue | Details |
A | VAL30 | |
A | LYS53 |
site_id | SWS_FT_FI3 |
Number of Residues | 1 |
Details | BINDING: |
Chain | Residue | Details |
A | GLU71 |
site_id | SWS_FT_FI4 |
Number of Residues | 1 |
Details | MOD_RES: Phosphothreonine; by MAP2K3, MAP2K4 and MAP2K6 => ECO:0000305|PubMed:15356147 |
Chain | Residue | Details |
A | THR180 |
site_id | SWS_FT_FI5 |
Number of Residues | 1 |
Details | MOD_RES: Phosphotyrosine; by MAP2K3, MAP2K4 and MAP2K6 => ECO:0000305|PubMed:15356147 |
Chain | Residue | Details |
A | TYR182 |
site_id | SWS_FT_FI6 |
Number of Residues | 1 |
Details | MOD_RES: Phosphotyrosine; by ZAP70 => ECO:0000250 |
Chain | Residue | Details |
A | TYR323 |