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3GFC

Crystal Structure of Histone-binding protein RBBP4

Functional Information from GO Data
ChainGOidnamespacecontents
A0000118cellular_componenthistone deacetylase complex
A0000122biological_processnegative regulation of transcription by RNA polymerase II
A0000781cellular_componentchromosome, telomeric region
A0000785cellular_componentchromatin
A0000978molecular_functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005694cellular_componentchromosome
A0005829cellular_componentcytosol
A0006260biological_processDNA replication
A0006325biological_processchromatin organization
A0006334biological_processnucleosome assembly
A0006335biological_processDNA replication-dependent chromatin assembly
A0006338biological_processchromatin remodeling
A0006355biological_processregulation of DNA-templated transcription
A0007049biological_processcell cycle
A0007420biological_processbrain development
A0008094molecular_functionATP-dependent activity, acting on DNA
A0008285biological_processnegative regulation of cell population proliferation
A0016581cellular_componentNuRD complex
A0016589cellular_componentNURF complex
A0030336biological_processnegative regulation of cell migration
A0030512biological_processnegative regulation of transforming growth factor beta receptor signaling pathway
A0031491molecular_functionnucleosome binding
A0031492molecular_functionnucleosomal DNA binding
A0032991cellular_componentprotein-containing complex
A0033186cellular_componentCAF-1 complex
A0035098cellular_componentESC/E(Z) complex
A0042393molecular_functionhistone binding
A0042659biological_processregulation of cell fate specification
A0042826molecular_functionhistone deacetylase binding
A0045892biological_processnegative regulation of DNA-templated transcription
A0045893biological_processpositive regulation of DNA-templated transcription
A0070822cellular_componentSin3-type complex
A1902455biological_processnegative regulation of stem cell population maintenance
A1902459biological_processpositive regulation of stem cell population maintenance
A1904949cellular_componentATPase complex
A2000736biological_processregulation of stem cell differentiation
Functional Information from PROSITE/UniProt
site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. LLSAsdDhTICLWDI
ChainResidueDetails
ALEU193-ILE207
ALEU289-LEU303
ALEU333-LEU347

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsMOD_RES: N-acetylalanine => ECO:0000269|Ref.9, ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22223895, ECO:0007744|PubMed:22814378
ChainResidueDetails
AALA2

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: N6-acetyllysine; alternate => ECO:0007744|PubMed:19608861
ChainResidueDetails
ALYS4

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER110

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: N6-acetyllysine; alternate => ECO:0000250|UniProtKB:Q60972
ChainResidueDetails
ALYS160

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER355

site_idSWS_FT_FI6
Number of Residues1
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate
ChainResidueDetails
ALYS4

site_idSWS_FT_FI7
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:25755297, ECO:0007744|PubMed:28112733
ChainResidueDetails
ALYS160

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PDB entries from 2024-04-24

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