3GDM

Crystal structure of the K93R mutant of the orotidine 5'-monophosphate decarboxylase from Saccharomyces cerevisiae

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004590	molecular_function	orotidine-5'-phosphate decarboxylase activity
A	0005829	cellular_component	cytosol
A	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
A	0006221	biological_process	pyrimidine nucleotide biosynthetic process
A	0006222	biological_process	UMP biosynthetic process
A	0016831	molecular_function	carboxy-lyase activity
A	0044205	biological_process	'de novo' UMP biosynthetic process
A	0055086	biological_process	nucleobase-containing small molecule metabolic process
A	0072528	biological_process	pyrimidine-containing compound biosynthetic process
B	0004590	molecular_function	orotidine-5'-phosphate decarboxylase activity
B	0005829	cellular_component	cytosol
B	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
B	0006221	biological_process	pyrimidine nucleotide biosynthetic process
B	0006222	biological_process	UMP biosynthetic process
B	0016831	molecular_function	carboxy-lyase activity
B	0044205	biological_process	'de novo' UMP biosynthetic process
B	0055086	biological_process	nucleobase-containing small molecule metabolic process
B	0072528	biological_process	pyrimidine-containing compound biosynthetic process

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: Proton donor

Chain	Residue	Details
A	ARG93
B	ARG93

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site_id	SWS_FT_FI2
Number of Residues	10
Details	BINDING:

Chain	Residue	Details
A	ASP37
B	LYS59
B	ASP91
B	TYR217
B	ARG235
A	LYS59
A	ASP91
A	TYR217
A	ARG235
B	ASP37

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site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: N-acetylserine => ECO:0007744|PubMed:22814378

Chain	Residue	Details
A	SER2
B	SER2

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site_id	SWS_FT_FI4
Number of Residues	8
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:12872131

Chain	Residue	Details
A	ARG93
A	LYS209
A	LYS253
B	ARG93
B	LYS209
B	LYS253

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