Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3FWP

X-ray structure of uridine nucleoside phosphorylease from Salmonella typhimurium complexed with phosphate and its inhibitor 2,2'-anhydrouridine at 1.86 A resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0004850	molecular_function	uridine phosphorylase activity
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0009116	biological_process	nucleoside metabolic process
A	0009164	biological_process	nucleoside catabolic process
A	0009166	biological_process	nucleotide catabolic process
A	0016757	molecular_function	glycosyltransferase activity
A	0016763	molecular_function	pentosyltransferase activity
A	0044206	biological_process	UMP salvage
B	0003824	molecular_function	catalytic activity
B	0004850	molecular_function	uridine phosphorylase activity
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0009116	biological_process	nucleoside metabolic process
B	0009164	biological_process	nucleoside catabolic process
B	0009166	biological_process	nucleotide catabolic process
B	0016757	molecular_function	glycosyltransferase activity
B	0016763	molecular_function	pentosyltransferase activity
B	0044206	biological_process	UMP salvage
C	0003824	molecular_function	catalytic activity
C	0004850	molecular_function	uridine phosphorylase activity
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0009116	biological_process	nucleoside metabolic process
C	0009164	biological_process	nucleoside catabolic process
C	0009166	biological_process	nucleotide catabolic process
C	0016757	molecular_function	glycosyltransferase activity
C	0016763	molecular_function	pentosyltransferase activity
C	0044206	biological_process	UMP salvage
D	0003824	molecular_function	catalytic activity
D	0004850	molecular_function	uridine phosphorylase activity
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0009116	biological_process	nucleoside metabolic process
D	0009164	biological_process	nucleoside catabolic process
D	0009166	biological_process	nucleotide catabolic process
D	0016757	molecular_function	glycosyltransferase activity
D	0016763	molecular_function	pentosyltransferase activity
D	0044206	biological_process	UMP salvage
E	0003824	molecular_function	catalytic activity
E	0004850	molecular_function	uridine phosphorylase activity
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0009116	biological_process	nucleoside metabolic process
E	0009164	biological_process	nucleoside catabolic process
E	0009166	biological_process	nucleotide catabolic process
E	0016757	molecular_function	glycosyltransferase activity
E	0016763	molecular_function	pentosyltransferase activity
E	0044206	biological_process	UMP salvage
F	0003824	molecular_function	catalytic activity
F	0004850	molecular_function	uridine phosphorylase activity
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0009116	biological_process	nucleoside metabolic process
F	0009164	biological_process	nucleoside catabolic process
F	0009166	biological_process	nucleotide catabolic process
F	0016757	molecular_function	glycosyltransferase activity
F	0016763	molecular_function	pentosyltransferase activity
F	0044206	biological_process	UMP salvage

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE PO4 B7006

Chain	Residue
B	GLY6026
B	ARG6030
B	ARG6091
B	ILE6092
B	GLY6093
B	THR6094
B	ANU7016
D	ARG3048

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE K B8001

Chain	Residue
B	ILE6069
B	SER6073
D	GLU3049
D	ILE3069
D	SER3073
B	GLU6049

site_id	AC3
Number of Residues	15
Details	BINDING SITE FOR RESIDUE ANU B7016

Chain	Residue
B	HOH111
B	HOH166
B	ILE6069
B	THR6094
B	THR6095
B	GLY6096
B	PHE6162
B	GLN6166
B	ARG6168
B	GLU6196
B	MET6197
B	GLU6198
B	PO47006
D	HIS3008
D	ARG3048

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE K C8221

Chain	Residue
C	GLU2049
C	ILE2069
C	SER2073
E	GLU5049
E	ILE5069
E	SER5073

site_id	AC5
Number of Residues	8
Details	BINDING SITE FOR RESIDUE PO4 D7003

Chain	Residue
B	ARG6048
D	GLY3026
D	ARG3030
D	ARG3091
D	ILE3092
D	GLY3093
D	THR3094
D	ANU7013

site_id	AC6
Number of Residues	14
Details	BINDING SITE FOR RESIDUE ANU D7013

Chain	Residue
B	HIS6008
B	ARG6048
D	HOH313
D	HOH943
D	ILE3069
D	THR3094
D	GLY3096
D	PHE3162
D	GLN3166
D	ARG3168
D	GLU3196
D	MET3197
D	GLU3198
D	PO47003

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE K F8002

Chain	Residue
A	GLU1049
A	ILE1069
A	SER1073
F	GLU4049
F	ILE4069
F	SER4073

site_id	AC8
Number of Residues	9
Details	BINDING SITE FOR RESIDUE PO4 F7004

Chain	Residue
A	ARG1048
F	HOH954
F	GLY4026
F	ARG4030
F	ARG4091
F	ILE4092
F	GLY4093
F	THR4094
F	ANU7014

site_id	AC9
Number of Residues	12
Details	BINDING SITE FOR RESIDUE ANU F7014

Chain	Residue
A	HIS1008
A	ARG1048
F	HOH479
F	ILE4069
F	THR4094
F	PHE4162
F	GLN4166
F	ARG4168
F	GLU4196
F	MET4197
F	GLU4198
F	PO47004

Functional Information from PROSITE/UniProt

site_id	PS01232
Number of Residues	16
Details	PNP_UDP_1 Purine and other phosphorylases family 1 signature. StGIGgPStSIaveEL

Chain	Residue	Details
A	SER1066-LEU1081

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)