Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3FDS

Structural insight into recruitment of translesion DNA polymerase Dpo4 to sliding clamp PCNA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0003677	molecular_function	DNA binding
A	0003684	molecular_function	damaged DNA binding
A	0003887	molecular_function	DNA-directed DNA polymerase activity
A	0005737	cellular_component	cytoplasm
A	0006260	biological_process	DNA replication
A	0006261	biological_process	DNA-templated DNA replication
A	0006281	biological_process	DNA repair
A	0006974	biological_process	DNA damage response
A	0042276	biological_process	error-prone translesion synthesis
A	0046872	molecular_function	metal ion binding
C	0003677	molecular_function	DNA binding
C	0006260	biological_process	DNA replication
C	0006272	biological_process	leading strand elongation
C	0006275	biological_process	regulation of DNA replication
C	0030337	molecular_function	DNA polymerase processivity factor activity
D	0003677	molecular_function	DNA binding
D	0006260	biological_process	DNA replication
D	0006272	biological_process	leading strand elongation
D	0006275	biological_process	regulation of DNA replication
D	0030337	molecular_function	DNA polymerase processivity factor activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO A 353

Chain	Residue
A	GLU94
A	HOH482
D	LYS81

site_id	AC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO A 354

Chain	Residue
A	GLY41
A	PRO60

site_id	AC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO A 355

Chain	Residue
A	GLU120
A	GLU127

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO A 356

Chain	Residue
C	GLY154
C	EDO250
A	HIS304
C	THR151

site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO A 357

Chain	Residue
A	TYR122
A	EDO362
A	EDO367

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO A 358

Chain	Residue
A	PHE302
A	PRO303
A	HIS304
A	GLY305

site_id	AC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO A 359

Chain	Residue
A	GLU79
A	GLN83

site_id	AC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 360

Chain	Residue
A	LEU19
A	VAL84
A	ARG87
A	HOH488
A	HOH590
D	LYS85

site_id	AC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO A 361

Chain	Residue
A	GLU100
A	LYS148

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO A 362

Chain	Residue
A	VAL165
A	ASP167
A	EDO357
A	HOH631

site_id	BC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO A 363

Chain	Residue
A	LYS137
A	HOH554
A	HOH658
A	HOH663

site_id	BC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO A 364

Chain	Residue
A	TYR48
A	LYS159
C	SER84

site_id	BC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO A 365

Chain	Residue
A	ARG51
A	LYS56
A	HOH615

site_id	BC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 366

Chain	Residue
A	ASN130
A	ASN161
A	HOH451
A	HOH559
C	GLU140
C	ARG213

site_id	BC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO A 367

Chain	Residue
A	LYS164
A	VAL165
A	EDO357
C	ASN17

site_id	BC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PEG A 369

Chain	Residue
A	TYR10
A	PRO160
A	ASN161
A	HOH435
C	LYS10

site_id	BC8
Number of Residues	15
Details	BINDING SITE FOR RESIDUE 1PE A 370

Chain	Residue
A	TYR122
A	ASN123
A	LEU126
A	ASN130
A	HOH559
A	HOH669
C	ASN17
C	THR20
C	ASN21
C	ASN144
C	LYS206
C	LYS210
C	ARG213
C	HOH475
C	HOH573

site_id	BC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL A 371

Chain	Residue
A	PHE11
A	TYR12
A	THR45
A	ILE104
A	ASP105
A	HOH595

site_id	CC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO C 250

Chain	Residue
A	EDO356
C	VAL153
C	GLU172
C	LYS175
C	PEG259

site_id	CC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO C 251

Chain	Residue
C	ARG38
C	HIS39
C	LEU40
C	HOH616

site_id	CC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO C 252

Chain	Residue
C	LYS54
C	TYR60
C	ILE62

site_id	CC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO C 253

Chain	Residue
C	ASN21
C	THR41
C	LEU46
C	ASP207

site_id	CC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO C 254

Chain	Residue
C	THR31
C	ARG51

site_id	CC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO C 255

Chain	Residue
C	ILE242
C	GLU127
C	LYS230
C	ASP232

site_id	CC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO C 256

Chain	Residue
C	THR138
C	ASP139
C	VAL142
C	PRO186
C	LEU187
C	LYS188

site_id	CC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO C 257

Chain	Residue
C	MET220
C	ASP232
C	HIS240
C	HOH418

site_id	CC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO C 258

Chain	Residue
C	GLY174
C	HOH654
D	LYS97
D	PRO113

site_id	DC1
Number of Residues	9
Details	BINDING SITE FOR RESIDUE PEG C 259

Chain	Residue
C	LEU152
C	VAL153
C	LYS175
C	ARG176
C	EDO250
C	HOH382
D	ASP78
D	GLU111
D	HOH546

site_id	DC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL C 260

Chain	Residue
A	LYS282
C	GLU156
C	ALA170
C	GLY171
C	GLU172
C	HOH495
C	HOH607
C	HOH618

site_id	DC3
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GOL C 261

Chain	Residue
A	ALA343
C	VAL45
C	TYR200
C	SER201
C	ALA246
C	ARG248
C	HOH513
C	HOH553
C	HOH560

site_id	DC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO D 246

Chain	Residue
D	LEU150
D	GLY151
D	GLU152
D	GLY169
D	ASP170
D	HOH575

site_id	DC5
Number of Residues	9
Details	BINDING SITE FOR RESIDUE PGE D 247

Chain	Residue
C	LYS175
D	GLY70
D	PHE71
D	LYS72
D	ASP75
D	LEU112
D	PRO113
D	HOH392
D	HOH598

Functional Information from PROSITE/UniProt

site_id	PS01251
Number of Residues	24
Details	PCNA_1 Proliferating cell nuclear antigen signature 1. GIrVsGIDpSRVvFLdIfLpssyF

Chain	Residue	Details
D	GLY34-PHE57

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE:

Chain	Residue	Details
A	GLU106

site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING:

Chain	Residue	Details
A	ASP7
A	ASP105

site_id	SWS_FT_FI3
Number of Residues	1
Details	SITE: Substrate discrimination

Chain	Residue	Details
A	TYR12

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)