Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3FBV

Crystal structure of the oligomer formed by the kinase-ribonuclease domain of Ire1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004521	molecular_function	RNA endonuclease activity
A	0004540	molecular_function	RNA nuclease activity
A	0004672	molecular_function	protein kinase activity
A	0004674	molecular_function	protein serine/threonine kinase activity
A	0005524	molecular_function	ATP binding
A	0006397	biological_process	mRNA processing
A	0006468	biological_process	protein phosphorylation
A	0030968	biological_process	endoplasmic reticulum unfolded protein response
B	0004521	molecular_function	RNA endonuclease activity
B	0004540	molecular_function	RNA nuclease activity
B	0004672	molecular_function	protein kinase activity
B	0004674	molecular_function	protein serine/threonine kinase activity
B	0005524	molecular_function	ATP binding
B	0006397	biological_process	mRNA processing
B	0006468	biological_process	protein phosphorylation
B	0030968	biological_process	endoplasmic reticulum unfolded protein response
C	0004521	molecular_function	RNA endonuclease activity
C	0004540	molecular_function	RNA nuclease activity
C	0004672	molecular_function	protein kinase activity
C	0004674	molecular_function	protein serine/threonine kinase activity
C	0005524	molecular_function	ATP binding
C	0006397	biological_process	mRNA processing
C	0006468	biological_process	protein phosphorylation
C	0030968	biological_process	endoplasmic reticulum unfolded protein response
D	0004521	molecular_function	RNA endonuclease activity
D	0004540	molecular_function	RNA nuclease activity
D	0004672	molecular_function	protein kinase activity
D	0004674	molecular_function	protein serine/threonine kinase activity
D	0005524	molecular_function	ATP binding
D	0006397	biological_process	mRNA processing
D	0006468	biological_process	protein phosphorylation
D	0030968	biological_process	endoplasmic reticulum unfolded protein response
E	0004521	molecular_function	RNA endonuclease activity
E	0004540	molecular_function	RNA nuclease activity
E	0004672	molecular_function	protein kinase activity
E	0004674	molecular_function	protein serine/threonine kinase activity
E	0005524	molecular_function	ATP binding
E	0006397	biological_process	mRNA processing
E	0006468	biological_process	protein phosphorylation
E	0030968	biological_process	endoplasmic reticulum unfolded protein response
F	0004521	molecular_function	RNA endonuclease activity
F	0004540	molecular_function	RNA nuclease activity
F	0004672	molecular_function	protein kinase activity
F	0004674	molecular_function	protein serine/threonine kinase activity
F	0005524	molecular_function	ATP binding
F	0006397	biological_process	mRNA processing
F	0006468	biological_process	protein phosphorylation
F	0030968	biological_process	endoplasmic reticulum unfolded protein response
G	0004521	molecular_function	RNA endonuclease activity
G	0004540	molecular_function	RNA nuclease activity
G	0004672	molecular_function	protein kinase activity
G	0004674	molecular_function	protein serine/threonine kinase activity
G	0005524	molecular_function	ATP binding
G	0006397	biological_process	mRNA processing
G	0006468	biological_process	protein phosphorylation
G	0030968	biological_process	endoplasmic reticulum unfolded protein response
H	0004521	molecular_function	RNA endonuclease activity
H	0004540	molecular_function	RNA nuclease activity
H	0004672	molecular_function	protein kinase activity
H	0004674	molecular_function	protein serine/threonine kinase activity
H	0005524	molecular_function	ATP binding
H	0006397	biological_process	mRNA processing
H	0006468	biological_process	protein phosphorylation
H	0030968	biological_process	endoplasmic reticulum unfolded protein response
I	0004521	molecular_function	RNA endonuclease activity
I	0004540	molecular_function	RNA nuclease activity
I	0004672	molecular_function	protein kinase activity
I	0004674	molecular_function	protein serine/threonine kinase activity
I	0005524	molecular_function	ATP binding
I	0006397	biological_process	mRNA processing
I	0006468	biological_process	protein phosphorylation
I	0030968	biological_process	endoplasmic reticulum unfolded protein response
J	0004521	molecular_function	RNA endonuclease activity
J	0004540	molecular_function	RNA nuclease activity
J	0004672	molecular_function	protein kinase activity
J	0004674	molecular_function	protein serine/threonine kinase activity
J	0005524	molecular_function	ATP binding
J	0006397	biological_process	mRNA processing
J	0006468	biological_process	protein phosphorylation
J	0030968	biological_process	endoplasmic reticulum unfolded protein response
K	0004521	molecular_function	RNA endonuclease activity
K	0004540	molecular_function	RNA nuclease activity
K	0004672	molecular_function	protein kinase activity
K	0004674	molecular_function	protein serine/threonine kinase activity
K	0005524	molecular_function	ATP binding
K	0006397	biological_process	mRNA processing
K	0006468	biological_process	protein phosphorylation
K	0030968	biological_process	endoplasmic reticulum unfolded protein response
L	0004521	molecular_function	RNA endonuclease activity
L	0004540	molecular_function	RNA nuclease activity
L	0004672	molecular_function	protein kinase activity
L	0004674	molecular_function	protein serine/threonine kinase activity
L	0005524	molecular_function	ATP binding
L	0006397	biological_process	mRNA processing
L	0006468	biological_process	protein phosphorylation
L	0030968	biological_process	endoplasmic reticulum unfolded protein response
M	0004521	molecular_function	RNA endonuclease activity
M	0004540	molecular_function	RNA nuclease activity
M	0004672	molecular_function	protein kinase activity
M	0004674	molecular_function	protein serine/threonine kinase activity
M	0005524	molecular_function	ATP binding
M	0006397	biological_process	mRNA processing
M	0006468	biological_process	protein phosphorylation
M	0030968	biological_process	endoplasmic reticulum unfolded protein response
N	0004521	molecular_function	RNA endonuclease activity
N	0004540	molecular_function	RNA nuclease activity
N	0004672	molecular_function	protein kinase activity
N	0004674	molecular_function	protein serine/threonine kinase activity
N	0005524	molecular_function	ATP binding
N	0006397	biological_process	mRNA processing
N	0006468	biological_process	protein phosphorylation
N	0030968	biological_process	endoplasmic reticulum unfolded protein response

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	BINDING SITE FOR RESIDUE APJ A1999

Chain	Residue
A	LEU680
A	TYR682
A	ALA700
A	LEU745
A	GLU746
A	CYS748
A	LEU750
A	ASP754
A	ASP828

site_id	AC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE APJ B1999

Chain	Residue
B	LEU680
B	TYR682
B	ALA700
B	LEU745
B	GLU746
B	CYS748
B	LEU750
B	ASP754
B	ASP828

site_id	AC3
Number of Residues	9
Details	BINDING SITE FOR RESIDUE APJ C1999

Chain	Residue
C	LEU680
C	TYR682
C	ALA700
C	LEU745
C	GLU746
C	CYS748
C	LEU750
C	ASP754
C	ASP828

site_id	AC4
Number of Residues	9
Details	BINDING SITE FOR RESIDUE APJ D1999

Chain	Residue
D	LEU680
D	TYR682
D	ALA700
D	LEU745
D	GLU746
D	CYS748
D	LEU750
D	ASP754
D	ASP828

site_id	AC5
Number of Residues	8
Details	BINDING SITE FOR RESIDUE APJ E1999

Chain	Residue
E	TYR682
E	ALA700
E	LEU745
E	GLU746
E	CYS748
E	LEU750
E	ASP754
E	ASP828

site_id	AC6
Number of Residues	9
Details	BINDING SITE FOR RESIDUE APJ F1999

Chain	Residue
F	LEU680
F	TYR682
F	ALA700
F	LEU745
F	GLU746
F	CYS748
F	LEU750
F	ASP754
F	ASP828

site_id	AC7
Number of Residues	9
Details	BINDING SITE FOR RESIDUE APJ G1999

Chain	Residue
G	LEU680
G	TYR682
G	ALA700
G	LEU745
G	GLU746
G	CYS748
G	LEU750
G	ASP754
G	ASP828

site_id	AC8
Number of Residues	9
Details	BINDING SITE FOR RESIDUE APJ H1999

Chain	Residue
H	LEU680
H	TYR682
H	ALA700
H	LEU745
H	GLU746
H	CYS748
H	LEU750
H	ASP754
H	ASP828

site_id	AC9
Number of Residues	9
Details	BINDING SITE FOR RESIDUE APJ I1999

Chain	Residue
I	LEU680
I	TYR682
I	ALA700
I	LEU745
I	GLU746
I	CYS748
I	LEU750
I	ASP754
I	ASP828

site_id	BC1
Number of Residues	9
Details	BINDING SITE FOR RESIDUE APJ J1999

Chain	Residue
J	LEU680
J	TYR682
J	ALA700
J	LEU745
J	GLU746
J	CYS748
J	LEU750
J	ASP754
J	ASP828

site_id	BC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE APJ K1999

Chain	Residue
K	LEU680
K	TYR682
K	ALA700
K	LEU745
K	GLU746
K	CYS748
K	LEU750
K	ASP754
K	ASP828

site_id	BC3
Number of Residues	9
Details	BINDING SITE FOR RESIDUE APJ L1999

Chain	Residue
L	TYR682
L	ALA700
L	LEU745
L	GLU746
L	CYS748
L	LEU750
L	ASP754
L	ASP828
L	LEU680

site_id	BC4
Number of Residues	9
Details	BINDING SITE FOR RESIDUE APJ M1999

Chain	Residue
M	LEU680
M	TYR682
M	ALA700
M	LEU745
M	GLU746
M	CYS748
M	LEU750
M	ASP754
M	ASP828

site_id	BC5
Number of Residues	9
Details	BINDING SITE FOR RESIDUE APJ N1999

Chain	Residue
N	LEU680
N	TYR682
N	ALA700
N	LEU745
N	GLU746
N	CYS748
N	LEU750
N	ASP754
N	ASP828

Functional Information from PROSITE/UniProt

site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IiHrDLKpqNILV

Chain	Residue	Details
A	ILE793-VAL805

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	14
Details	ACT_SITE: Proton acceptor => ECO:0000255\|PROSITE-ProRule:PRU00159, ECO:0000255\|PROSITE-ProRule:PRU10027

Chain	Residue	Details
A	ASP797
J	ASP797
K	ASP797
L	ASP797
M	ASP797
N	ASP797
B	ASP797
C	ASP797
D	ASP797
E	ASP797
F	ASP797
G	ASP797
H	ASP797
I	ASP797

site_id	SWS_FT_FI2
Number of Residues	14
Details	BINDING: BINDING => ECO:0000255\|PROSITE-ProRule:PRU00159

Chain	Residue	Details
A	LEU680
J	LEU680
K	LEU680
L	LEU680
M	LEU680
N	LEU680
B	LEU680
C	LEU680
D	LEU680
E	LEU680
F	LEU680
G	LEU680
H	LEU680
I	LEU680

site_id	SWS_FT_FI3
Number of Residues	14
Details	BINDING:

Chain	Residue	Details
A	LYS702
J	LYS702
K	LYS702
L	LYS702
M	LYS702
N	LYS702
B	LYS702
C	LYS702
D	LYS702
E	LYS702
F	LYS702
G	LYS702
H	LYS702
I	LYS702

site_id	SWS_FT_FI4
Number of Residues	28
Details	MOD_RES: Phosphoserine; by autocatalysis => ECO:0000305\|PubMed:8670804

Chain	Residue	Details
A	SEP840
E	SEP841
F	SEP840
F	SEP841
G	SEP840
G	SEP841
H	SEP840
H	SEP841
I	SEP840
I	SEP841
J	SEP840
A	SEP841
J	SEP841
K	SEP840
K	SEP841
L	SEP840
L	SEP841
M	SEP840
M	SEP841
N	SEP840
N	SEP841
B	SEP840
B	SEP841
C	SEP840
C	SEP841
D	SEP840
D	SEP841
E	SEP840

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)