Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004190 | molecular_function | aspartic-type endopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
| B | 0004190 | molecular_function | aspartic-type endopeptidase activity |
| B | 0006508 | biological_process | proteolysis |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE GRL A 201 |
| Chain | Residue |
| A | ASP25 |
| A | HOH1017 |
| A | HOH1079 |
| B | ASP125 |
| B | GLY127 |
| B | ALA128 |
| B | ASP129 |
| B | ASP130 |
| B | VAL147 |
| B | GLY148 |
| B | GLY149 |
| A | GLY27 |
| B | ILE150 |
| B | CL502 |
| A | ASP29 |
| A | ASP30 |
| A | ILE32 |
| A | GLY48 |
| A | GLY49 |
| A | ILE82 |
| A | ILE84 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE IMD A 304 |
| Chain | Residue |
| A | GLN2 |
| A | PHE3 |
| A | LEU99 |
| A | ZN403 |
| A | HOH1007 |
| B | PRO101 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE IMD A 306 |
| Chain | Residue |
| A | TYR14 |
| A | GLY17 |
| A | GLU63 |
| A | GLU65 |
| A | ZN406 |
| A | ZN410 |
| A | HOH1011 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN A 403 |
| Chain | Residue |
| A | LEU99 |
| A | IMD304 |
| A | CL508 |
| A | HOH1006 |
| A | HOH1007 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 405 |
| Chain | Residue |
| A | ASP79 |
| A | HOH1028 |
| A | HOH1029 |
| B | GLU137 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN A 406 |
| Chain | Residue |
| A | GLU65 |
| A | GLU65 |
| A | IMD306 |
| A | HOH1004 |
| A | HOH1004 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ZN A 410 |
| Chain | Residue |
| A | GLU63 |
| A | GLU65 |
| A | IMD306 |
| A | CL507 |
| A | HOH1010 |
| A | HOH1011 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CL A 507 |
| Chain | Residue |
| A | GLU63 |
| A | ASN68 |
| A | LYS69 |
| A | LYS70 |
| A | ZN410 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CL A 508 |
| Chain | Residue |
| A | LYS7 |
| A | LEU99 |
| A | ZN403 |
| A | HOH1007 |
| A | HOH1097 |
| A | HOH1178 |
| site_id | BC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE NA A 601 |
| Chain | Residue |
| A | ASN40 |
| A | ASN41 |
| A | PRO44 |
| A | HOH1063 |
| A | HOH1084 |
| A | HOH1101 |
| B | ASN140 |
| site_id | BC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE IMD B 301 |
| Chain | Residue |
| B | GLU121 |
| B | ILE146 |
| B | PHE153 |
| B | ASN155 |
| B | ASP179 |
| B | IMD302 |
| B | ZN401 |
| site_id | BC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE IMD B 302 |
| Chain | Residue |
| B | GLU121 |
| B | PHE153 |
| B | ASP179 |
| B | IMD301 |
| B | ZN401 |
| B | HOH1137 |
| site_id | BC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE IMD B 303 |
| Chain | Residue |
| B | ASP130 |
| B | ILE146 |
| B | MET176 |
| B | ZN402 |
| B | ZN409 |
| B | CL501 |
| B | CL502 |
| site_id | BC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE IMD B 305 |
| Chain | Residue |
| A | ARG8 |
| A | PRO81 |
| B | TRP106 |
| B | ZN404 |
| B | CL505 |
| B | HOH1058 |
| site_id | BC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 401 |
| Chain | Residue |
| B | ASP179 |
| B | IMD301 |
| B | IMD302 |
| B | GLU121 |
| site_id | BC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ZN B 402 |
| Chain | Residue |
| B | ASP130 |
| B | IMD303 |
| B | ZN409 |
| B | CL502 |
| B | CL506 |
| B | HOH1001 |
| site_id | BC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 404 |
| Chain | Residue |
| B | IMD305 |
| B | CL504 |
| B | CL505 |
| B | HOH1009 |
| site_id | BC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN B 407 |
| Chain | Residue |
| B | GLU165 |
| B | CL503 |
| B | HOH1002 |
| B | HOH1003 |
| B | HOH1005 |
| site_id | CC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE ZN B 408 |
| Chain | Residue |
| B | GLU158 |
| B | HOH1150 |
| site_id | CC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN B 409 |
| Chain | Residue |
| B | ASP130 |
| B | IMD303 |
| B | ZN402 |
| B | CL506 |
| B | HOH1001 |
| site_id | CC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CL B 501 |
| Chain | Residue |
| B | THR112 |
| B | LYS145 |
| B | ILE146 |
| B | IMD303 |
| B | HOH1049 |
| B | HOH1088 |
| site_id | CC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CL B 502 |
| Chain | Residue |
| A | GRL201 |
| B | VAL147 |
| B | GLY148 |
| B | IMD303 |
| B | ZN402 |
| B | HOH1008 |
| site_id | CC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL B 503 |
| Chain | Residue |
| B | GLU165 |
| B | ZN407 |
| B | HOH1003 |
| B | HOH1005 |
| site_id | CC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CL B 504 |
| Chain | Residue |
| B | SER104 |
| B | LEU105 |
| B | TRP106 |
| B | LYS107 |
| B | ZN404 |
| B | HOH1095 |
| site_id | CC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL B 505 |
| Chain | Residue |
| A | ARG8 |
| B | IMD305 |
| B | ZN404 |
| site_id | CC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL B 506 |
| Chain | Residue |
| B | ASP130 |
| B | ZN402 |
| B | ZN409 |
| B | HOH1001 |
Functional Information from PROSITE/UniProt
| site_id | PS00141 |
| Number of Residues | 12 |
| Details | ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. VLLDTGADDSIV |
| Chain | Residue | Details |
| A | VAL22-VAL33 | |
Functional Information from SwissProt/UniProt
| Chain | Residue | Details |
| A | ASP25 | |
| B | ASP125 | |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | SITE: Cleavage; by viral protease => ECO:0000250 |
| Chain | Residue | Details |
| A | LEU99 | |
| B | LEU199 | |
