3C66
Yeast poly(A) polymerase in complex with Fip1 residues 80-105
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0003723 | molecular_function | RNA binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005847 | cellular_component | mRNA cleavage and polyadenylation specificity factor complex |
| A | 0006397 | biological_process | mRNA processing |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016779 | molecular_function | nucleotidyltransferase activity |
| A | 0030846 | biological_process | termination of RNA polymerase II transcription, poly(A)-coupled |
| A | 0031123 | biological_process | RNA 3'-end processing |
| A | 0031124 | biological_process | mRNA 3'-end processing |
| A | 0031126 | biological_process | sno(s)RNA 3'-end processing |
| A | 0043631 | biological_process | obsolete RNA polyadenylation |
| A | 0046872 | molecular_function | metal ion binding |
| A | 1990817 | molecular_function | poly(A) RNA polymerase activity |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0003723 | molecular_function | RNA binding |
| B | 0005515 | molecular_function | protein binding |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005847 | cellular_component | mRNA cleavage and polyadenylation specificity factor complex |
| B | 0006397 | biological_process | mRNA processing |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016779 | molecular_function | nucleotidyltransferase activity |
| B | 0030846 | biological_process | termination of RNA polymerase II transcription, poly(A)-coupled |
| B | 0031123 | biological_process | RNA 3'-end processing |
| B | 0031124 | biological_process | mRNA 3'-end processing |
| B | 0031126 | biological_process | sno(s)RNA 3'-end processing |
| B | 0043631 | biological_process | obsolete RNA polyadenylation |
| B | 0046872 | molecular_function | metal ion binding |
| B | 1990817 | molecular_function | poly(A) RNA polymerase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MES A 538 |
| Chain | Residue |
| A | ILE9 |
| A | THR10 |
| A | ARG242 |
| A | TRP266 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MES B 538 |
| Chain | Residue |
| B | HOH601 |
| B | ILE9 |
| B | THR10 |
| B | ARG242 |
| B | TRP266 |
| B | GLN270 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MES B 539 |
| Chain | Residue |
| B | LYS34 |
| B | ILE209 |
| B | HOH605 |
| B | HOH627 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL A 539 |
| Chain | Residue |
| A | SER14 |
| A | VAL16 |
| A | ALA250 |
| A | ARG258 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL A 540 |
| Chain | Residue |
| A | GLN60 |
| A | ARG78 |
| A | GLY81 |
| A | GLY82 |
| A | VAL165 |
| A | PRO166 |
| A | LEU167 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL A 541 |
| Chain | Residue |
| A | ASP79 |
| A | GLN164 |
| B | GOL542 |
| site_id | AC7 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE GOL A 542 |
| Chain | Residue |
| A | ARG208 |
| A | ILE209 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL A 543 |
| Chain | Residue |
| A | GLY232 |
| A | GLY233 |
| A | VAL234 |
| A | ALA235 |
| A | ALA312 |
| site_id | AC9 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE GOL B 540 |
| Chain | Residue |
| B | ASP279 |
| B | GLY280 |
| site_id | BC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL B 541 |
| Chain | Residue |
| B | GLY232 |
| B | GLY233 |
| B | VAL234 |
| B | ALA235 |
| B | HOH549 |
| B | HOH569 |
| B | HOH617 |
| site_id | BC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL B 542 |
| Chain | Residue |
| A | GOL541 |
| B | GLN162 |
| B | PRO163 |
| B | GLN164 |
| B | PRO166 |
| B | LEU169 |
| site_id | BC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL B 543 |
| Chain | Residue |
| A | LYS342 |
| B | SER14 |
| B | VAL16 |
| B | GLU22 |
| B | TYR247 |
| B | ALA250 |
| site_id | BC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL B 544 |
| Chain | Residue |
| B | ASN189 |
| B | ARG285 |
| B | PRO308 |
| B | MET310 |
| site_id | BC5 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL B 545 |
| Chain | Residue |
| B | PRO269 |
| B | TRP287 |
| B | PRO289 |
| B | ASP295 |
| B | ARG296 |
| B | HIS298 |
| B | PRO301 |
| B | HOH589 |
Functional Information from PROSITE/UniProt
| site_id | PS00430 |
| Number of Residues | 109 |
| Details | TONB_DEPENDENT_REC_1 TonB-dependent receptor (TBDR) proteins signature 1. mssqkvfgitgpvstvgataaenklndsliqelkkegsfeteqetanrvqvlkilqelaqrfvyevskkknmsdgmardaggkiftygsyrlgvhgpgsdi..............DTLVVVPK |
| Chain | Residue | Details |
| A | MET1-LYS109 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 10 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:17850751 |
| Chain | Residue | Details |
| A | TYR87 | |
| B | TYR224 | |
| B | GLY233 | |
| A | SER99 | |
| A | LYS215 | |
| A | TYR224 | |
| A | GLY233 | |
| B | TYR87 | |
| B | SER99 | |
| B | LYS215 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | ASP100 | |
| A | ASP102 | |
| A | ASP154 | |
| B | ASP100 | |
| B | ASP102 | |
| B | ASP154 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 16 |
| Details | SITE: Interaction with RNA |
| Chain | Residue | Details |
| A | LYS392 | |
| A | GLU487 | |
| B | PHE140 | |
| B | LYS145 | |
| B | GLN294 | |
| B | HIS314 | |
| B | ASN315 | |
| B | ARG387 | |
| B | LYS392 | |
| B | GLU487 | |
| A | PHE140 | |
| A | LYS145 | |
| A | GLN294 | |
| A | HIS314 | |
| A | ASN315 | |
| A | ARG387 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18407956 |
| Chain | Residue | Details |
| A | SER452 | |
| B | SER452 |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 6 |
| Details | M-CSA 796 |
| Chain | Residue | Details |
| A | SER89 | electrostatic stabiliser, polar interaction |
| A | ASP100 | metal ligand |
| A | ASP102 | metal ligand |
| A | ASP154 | metal ligand |
| A | LYS215 | electrostatic stabiliser, polar interaction |
| A | TYR224 | electrostatic stabiliser, polar interaction |
| site_id | MCSA2 |
| Number of Residues | 6 |
| Details | M-CSA 796 |
| Chain | Residue | Details |
| B | SER89 | electrostatic stabiliser, polar interaction |
| B | ASP100 | metal ligand |
| B | ASP102 | metal ligand |
| B | ASP154 | metal ligand |
| B | LYS215 | electrostatic stabiliser, polar interaction |
| B | TYR224 | electrostatic stabiliser, polar interaction |
