Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2Z6K

Crystal structure of full-length human RPA14/32 heterodimer

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000723	biological_process	telomere maintenance
A	0000724	biological_process	double-strand break repair via homologous recombination
A	0000781	cellular_component	chromosome, telomeric region
A	0000785	cellular_component	chromatin
A	0003677	molecular_function	DNA binding
A	0003684	molecular_function	damaged DNA binding
A	0003697	molecular_function	single-stranded DNA binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005662	cellular_component	DNA replication factor A complex
A	0006260	biological_process	DNA replication
A	0006281	biological_process	DNA repair
A	0006284	biological_process	base-excision repair
A	0006289	biological_process	nucleotide-excision repair
A	0006298	biological_process	mismatch repair
A	0006310	biological_process	DNA recombination
A	0006974	biological_process	DNA damage response
A	0010569	biological_process	regulation of double-strand break repair via homologous recombination
A	0016604	cellular_component	nuclear body
A	0016605	cellular_component	PML body
A	0019899	molecular_function	enzyme binding
A	0019903	molecular_function	protein phosphatase binding
A	0031571	biological_process	mitotic G1 DNA damage checkpoint signaling
A	0031625	molecular_function	ubiquitin protein ligase binding
A	0034502	biological_process	protein localization to chromosome
A	0035861	cellular_component	site of double-strand break
A	0042162	molecular_function	telomeric DNA binding
A	0098505	molecular_function	G-rich strand telomeric DNA binding
A	2000001	biological_process	regulation of DNA damage checkpoint
B	0000723	biological_process	telomere maintenance
B	0000724	biological_process	double-strand break repair via homologous recombination
B	0000781	cellular_component	chromosome, telomeric region
B	0000785	cellular_component	chromatin
B	0003677	molecular_function	DNA binding
B	0003684	molecular_function	damaged DNA binding
B	0003697	molecular_function	single-stranded DNA binding
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005662	cellular_component	DNA replication factor A complex
B	0006260	biological_process	DNA replication
B	0006281	biological_process	DNA repair
B	0006284	biological_process	base-excision repair
B	0006289	biological_process	nucleotide-excision repair
B	0006298	biological_process	mismatch repair
B	0006310	biological_process	DNA recombination
B	0006974	biological_process	DNA damage response
B	0010569	biological_process	regulation of double-strand break repair via homologous recombination
B	0016604	cellular_component	nuclear body
B	0016605	cellular_component	PML body
B	0019899	molecular_function	enzyme binding
B	0019903	molecular_function	protein phosphatase binding
B	0031571	biological_process	mitotic G1 DNA damage checkpoint signaling
B	0031625	molecular_function	ubiquitin protein ligase binding
B	0034502	biological_process	protein localization to chromosome
B	0035861	cellular_component	site of double-strand break
B	0042162	molecular_function	telomeric DNA binding
B	0098505	molecular_function	G-rich strand telomeric DNA binding
B	2000001	biological_process	regulation of DNA damage checkpoint
C	0000723	biological_process	telomere maintenance
C	0000724	biological_process	double-strand break repair via homologous recombination
C	0003677	molecular_function	DNA binding
C	0003684	molecular_function	damaged DNA binding
C	0003697	molecular_function	single-stranded DNA binding
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005662	cellular_component	DNA replication factor A complex
C	0006260	biological_process	DNA replication
C	0006281	biological_process	DNA repair
C	0006284	biological_process	base-excision repair
C	0006289	biological_process	nucleotide-excision repair
C	0006298	biological_process	mismatch repair
C	0006310	biological_process	DNA recombination
C	0006974	biological_process	DNA damage response
C	0007346	biological_process	regulation of mitotic cell cycle
C	0031981	cellular_component	nuclear lumen
C	0035861	cellular_component	site of double-strand break
C	0042127	biological_process	regulation of cell population proliferation
D	0000723	biological_process	telomere maintenance
D	0000724	biological_process	double-strand break repair via homologous recombination
D	0003677	molecular_function	DNA binding
D	0003684	molecular_function	damaged DNA binding
D	0003697	molecular_function	single-stranded DNA binding
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005662	cellular_component	DNA replication factor A complex
D	0006260	biological_process	DNA replication
D	0006281	biological_process	DNA repair
D	0006284	biological_process	base-excision repair
D	0006289	biological_process	nucleotide-excision repair
D	0006298	biological_process	mismatch repair
D	0006310	biological_process	DNA recombination
D	0006974	biological_process	DNA damage response
D	0007346	biological_process	regulation of mitotic cell cycle
D	0031981	cellular_component	nuclear lumen
D	0035861	cellular_component	site of double-strand break
D	0042127	biological_process	regulation of cell population proliferation

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	MOD_RES: N-acetylvaline => ECO:0007744\|PubMed:19413330, ECO:0007744\|PubMed:22223895, ECO:0007744\|PubMed:22814378

Chain	Residue	Details
C	VAL2
D	VAL2

site_id	SWS_FT_FI2
Number of Residues	8
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269\|PubMed:26474068

Chain	Residue	Details
C	LYS23
B	MET1
C	LYS39
C	LYS88
D	LYS23
D	LYS39
D	LYS88

site_id	SWS_FT_FI3
Number of Residues	4
Details	MOD_RES: Phosphoserine; by PRKDC => ECO:0000269\|PubMed:21731742, ECO:0000269\|PubMed:26474068

Chain	Residue	Details
A	SER4
A	SER8
B	SER4
B	SER8

site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: Phosphothreonine; by PRKDC => ECO:0000269\|PubMed:21558276, ECO:0000269\|PubMed:26474068, ECO:0000269\|PubMed:9139719, ECO:0000269\|PubMed:9295339

Chain	Residue	Details
A	THR21
B	THR21

site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: Phosphoserine; by CDK2 => ECO:0000269\|PubMed:1318195, ECO:0000269\|PubMed:8246944, ECO:0000269\|PubMed:9295339, ECO:0007744\|PubMed:20068231

Chain	Residue	Details
A	SER23
B	SER23

site_id	SWS_FT_FI6
Number of Residues	2
Details	MOD_RES: Phosphoserine; by CDK1 => ECO:0000269\|PubMed:1318195, ECO:0000269\|PubMed:8246944, ECO:0000269\|PubMed:9139719, ECO:0000269\|PubMed:9295339, ECO:0007744\|PubMed:20068231

Chain	Residue	Details
A	SER29
B	SER29

site_id	SWS_FT_FI7
Number of Residues	2
Details	MOD_RES: Phosphoserine; by PRKDC => ECO:0000269\|PubMed:26474068, ECO:0000269\|PubMed:9139719, ECO:0000269\|PubMed:9295339

Chain	Residue	Details
A	SER33
B	SER33

site_id	SWS_FT_FI8
Number of Residues	6
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000305\|PubMed:26474068

Chain	Residue	Details
A	LYS37
A	LYS38
B	LYS37
B	LYS38

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)