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2Z1B

Crystal Structure of 5-aminolevulinic acid dehydratase (ALAD) from Mus musculs

Functional Information from GO Data
ChainGOidnamespacecontents
A0001666biological_processresponse to hypoxia
A0004655molecular_functionporphobilinogen synthase activity
A0005615cellular_componentextracellular space
A0005829cellular_componentcytosol
A0006782biological_processprotoporphyrinogen IX biosynthetic process
A0006783biological_processheme biosynthetic process
A0006784biological_processheme A biosynthetic process
A0006785biological_processheme B biosynthetic process
A0006979biological_processresponse to oxidative stress
A0007584biological_processresponse to nutrient
A0008270molecular_functionzinc ion binding
A0009410biological_processresponse to xenobiotic stimulus
A0009635biological_processresponse to herbicide
A0009636biological_processresponse to toxic substance
A0009725biological_processresponse to hormone
A0010033biological_processresponse to organic substance
A0010035biological_processresponse to inorganic substance
A0010038biological_processresponse to metal ion
A0010039biological_processresponse to iron ion
A0010043biological_processresponse to zinc ion
A0010044biological_processresponse to aluminum ion
A0010212biological_processresponse to ionizing radiation
A0010266biological_processresponse to vitamin B1
A0010269biological_processresponse to selenium ion
A0010288biological_processresponse to lead ion
A0014070biological_processresponse to organic cyclic compound
A0014823biological_processresponse to activity
A0016829molecular_functionlyase activity
A0031667biological_processresponse to nutrient levels
A0032025biological_processresponse to cobalt ion
A0032496biological_processresponse to lipopolysaccharide
A0033014biological_processtetrapyrrole biosynthetic process
A0033197biological_processresponse to vitamin E
A0033273biological_processresponse to vitamin
A0042802molecular_functionidentical protein binding
A0043200biological_processresponse to amino acid
A0045471biological_processresponse to ethanol
A0046685biological_processresponse to arsenic-containing substance
A0046686biological_processresponse to cadmium ion
A0046689biological_processresponse to mercury ion
A0046872molecular_functionmetal ion binding
A0048034biological_processheme O biosynthetic process
A0051260biological_processprotein homooligomerization
A0051384biological_processresponse to glucocorticoid
A0051597biological_processresponse to methylmercury
A0070541biological_processresponse to platinum ion
A0070542biological_processresponse to fatty acid
A0071284biological_processcellular response to lead ion
A0071353biological_processcellular response to interleukin-4
A1901799biological_processnegative regulation of proteasomal protein catabolic process
A1904854molecular_functionproteasome core complex binding
B0001666biological_processresponse to hypoxia
B0004655molecular_functionporphobilinogen synthase activity
B0005615cellular_componentextracellular space
B0005829cellular_componentcytosol
B0006782biological_processprotoporphyrinogen IX biosynthetic process
B0006783biological_processheme biosynthetic process
B0006784biological_processheme A biosynthetic process
B0006785biological_processheme B biosynthetic process
B0006979biological_processresponse to oxidative stress
B0007584biological_processresponse to nutrient
B0008270molecular_functionzinc ion binding
B0009410biological_processresponse to xenobiotic stimulus
B0009635biological_processresponse to herbicide
B0009636biological_processresponse to toxic substance
B0009725biological_processresponse to hormone
B0010033biological_processresponse to organic substance
B0010035biological_processresponse to inorganic substance
B0010038biological_processresponse to metal ion
B0010039biological_processresponse to iron ion
B0010043biological_processresponse to zinc ion
B0010044biological_processresponse to aluminum ion
B0010212biological_processresponse to ionizing radiation
B0010266biological_processresponse to vitamin B1
B0010269biological_processresponse to selenium ion
B0010288biological_processresponse to lead ion
B0014070biological_processresponse to organic cyclic compound
B0014823biological_processresponse to activity
B0016829molecular_functionlyase activity
B0031667biological_processresponse to nutrient levels
B0032025biological_processresponse to cobalt ion
B0032496biological_processresponse to lipopolysaccharide
B0033014biological_processtetrapyrrole biosynthetic process
B0033197biological_processresponse to vitamin E
B0033273biological_processresponse to vitamin
B0042802molecular_functionidentical protein binding
B0043200biological_processresponse to amino acid
B0045471biological_processresponse to ethanol
B0046685biological_processresponse to arsenic-containing substance
B0046686biological_processresponse to cadmium ion
B0046689biological_processresponse to mercury ion
B0046872molecular_functionmetal ion binding
B0048034biological_processheme O biosynthetic process
B0051260biological_processprotein homooligomerization
B0051384biological_processresponse to glucocorticoid
B0051597biological_processresponse to methylmercury
B0070541biological_processresponse to platinum ion
B0070542biological_processresponse to fatty acid
B0071284biological_processcellular response to lead ion
B0071353biological_processcellular response to interleukin-4
B1901799biological_processnegative regulation of proteasomal protein catabolic process
B1904854molecular_functionproteasome core complex binding
C0001666biological_processresponse to hypoxia
C0004655molecular_functionporphobilinogen synthase activity
C0005615cellular_componentextracellular space
C0005829cellular_componentcytosol
C0006782biological_processprotoporphyrinogen IX biosynthetic process
C0006783biological_processheme biosynthetic process
C0006784biological_processheme A biosynthetic process
C0006785biological_processheme B biosynthetic process
C0006979biological_processresponse to oxidative stress
C0007584biological_processresponse to nutrient
C0008270molecular_functionzinc ion binding
C0009410biological_processresponse to xenobiotic stimulus
C0009635biological_processresponse to herbicide
C0009636biological_processresponse to toxic substance
C0009725biological_processresponse to hormone
C0010033biological_processresponse to organic substance
C0010035biological_processresponse to inorganic substance
C0010038biological_processresponse to metal ion
C0010039biological_processresponse to iron ion
C0010043biological_processresponse to zinc ion
C0010044biological_processresponse to aluminum ion
C0010212biological_processresponse to ionizing radiation
C0010266biological_processresponse to vitamin B1
C0010269biological_processresponse to selenium ion
C0010288biological_processresponse to lead ion
C0014070biological_processresponse to organic cyclic compound
C0014823biological_processresponse to activity
C0016829molecular_functionlyase activity
C0031667biological_processresponse to nutrient levels
C0032025biological_processresponse to cobalt ion
C0032496biological_processresponse to lipopolysaccharide
C0033014biological_processtetrapyrrole biosynthetic process
C0033197biological_processresponse to vitamin E
C0033273biological_processresponse to vitamin
C0042802molecular_functionidentical protein binding
C0043200biological_processresponse to amino acid
C0045471biological_processresponse to ethanol
C0046685biological_processresponse to arsenic-containing substance
C0046686biological_processresponse to cadmium ion
C0046689biological_processresponse to mercury ion
C0046872molecular_functionmetal ion binding
C0048034biological_processheme O biosynthetic process
C0051260biological_processprotein homooligomerization
C0051384biological_processresponse to glucocorticoid
C0051597biological_processresponse to methylmercury
C0070541biological_processresponse to platinum ion
C0070542biological_processresponse to fatty acid
C0071284biological_processcellular response to lead ion
C0071353biological_processcellular response to interleukin-4
C1901799biological_processnegative regulation of proteasomal protein catabolic process
C1904854molecular_functionproteasome core complex binding
D0001666biological_processresponse to hypoxia
D0004655molecular_functionporphobilinogen synthase activity
D0005615cellular_componentextracellular space
D0005829cellular_componentcytosol
D0006782biological_processprotoporphyrinogen IX biosynthetic process
D0006783biological_processheme biosynthetic process
D0006784biological_processheme A biosynthetic process
D0006785biological_processheme B biosynthetic process
D0006979biological_processresponse to oxidative stress
D0007584biological_processresponse to nutrient
D0008270molecular_functionzinc ion binding
D0009410biological_processresponse to xenobiotic stimulus
D0009635biological_processresponse to herbicide
D0009636biological_processresponse to toxic substance
D0009725biological_processresponse to hormone
D0010033biological_processresponse to organic substance
D0010035biological_processresponse to inorganic substance
D0010038biological_processresponse to metal ion
D0010039biological_processresponse to iron ion
D0010043biological_processresponse to zinc ion
D0010044biological_processresponse to aluminum ion
D0010212biological_processresponse to ionizing radiation
D0010266biological_processresponse to vitamin B1
D0010269biological_processresponse to selenium ion
D0010288biological_processresponse to lead ion
D0014070biological_processresponse to organic cyclic compound
D0014823biological_processresponse to activity
D0016829molecular_functionlyase activity
D0031667biological_processresponse to nutrient levels
D0032025biological_processresponse to cobalt ion
D0032496biological_processresponse to lipopolysaccharide
D0033014biological_processtetrapyrrole biosynthetic process
D0033197biological_processresponse to vitamin E
D0033273biological_processresponse to vitamin
D0042802molecular_functionidentical protein binding
D0043200biological_processresponse to amino acid
D0045471biological_processresponse to ethanol
D0046685biological_processresponse to arsenic-containing substance
D0046686biological_processresponse to cadmium ion
D0046689biological_processresponse to mercury ion
D0046872molecular_functionmetal ion binding
D0048034biological_processheme O biosynthetic process
D0051260biological_processprotein homooligomerization
D0051384biological_processresponse to glucocorticoid
D0051597biological_processresponse to methylmercury
D0070541biological_processresponse to platinum ion
D0070542biological_processresponse to fatty acid
D0071284biological_processcellular response to lead ion
D0071353biological_processcellular response to interleukin-4
D1901799biological_processnegative regulation of proteasomal protein catabolic process
D1904854molecular_functionproteasome core complex binding
Functional Information from PROSITE/UniProt
site_idPS00169
Number of Residues13
DetailsD_ALA_DEHYDRATASE Delta-aminolevulinic acid dehydratase active site. GaDmLMVKPGlpY
ChainResidueDetails
AGLY245-TYR257

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues8
DetailsACT_SITE: Schiff-base intermediate with substrate => ECO:0000250
ChainResidueDetails
ALYS199
ALYS252
BLYS199
BLYS252
CLYS199
CLYS252
DLYS199
DLYS252

site_idSWS_FT_FI2
Number of Residues36
DetailsBINDING: BINDING => ECO:0000250
ChainResidueDetails
ACYS122
BCYS122
BCYS124
BHIS131
BCYS132
BARG209
BARG221
BCYS223
BSER279
BTYR318
CCYS122
ACYS124
CCYS124
CHIS131
CCYS132
CARG209
CARG221
CCYS223
CSER279
CTYR318
DCYS122
DCYS124
AHIS131
DHIS131
DCYS132
DARG209
DARG221
DCYS223
DSER279
DTYR318
ACYS132
AARG209
AARG221
ACYS223
ASER279
ATYR318

site_idSWS_FT_FI3
Number of Residues8
DetailsMOD_RES: N6-succinyllysine => ECO:0007744|PubMed:23806337
ChainResidueDetails
ALYS199
ALYS252
BLYS199
BLYS252
CLYS199
CLYS252
DLYS199
DLYS252

site_idSWS_FT_FI4
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:17242355, ECO:0007744|PubMed:21183079
ChainResidueDetails
ASER215
BSER215
CSER215
DSER215

Catalytic Information from CSA
site_idCSA1
Number of Residues4
DetailsAnnotated By Reference To The Literature 1h7o
ChainResidueDetails
ALYS199
AASP120
ALYS252
ASER168

site_idCSA2
Number of Residues4
DetailsAnnotated By Reference To The Literature 1h7o
ChainResidueDetails
BLYS199
BASP120
BLYS252
BSER168

site_idCSA3
Number of Residues4
DetailsAnnotated By Reference To The Literature 1h7o
ChainResidueDetails
CLYS199
CASP120
CLYS252
CSER168

site_idCSA4
Number of Residues4
DetailsAnnotated By Reference To The Literature 1h7o
ChainResidueDetails
DLYS199
DASP120
DLYS252
DSER168

219140

PDB entries from 2024-05-01

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