2YLL

Inhibition of the pneumococcal virulence factor StrH and molecular insights into N-glycan recognition and hydrolysis

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004553	molecular_function	hydrolase activity, hydrolyzing O-glycosyl compounds
A	0005975	biological_process	carbohydrate metabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CA A 1615

Chain	Residue
A	GLU361
A	HOH2026
A	HOH2299
A	HOH2300
A	HOH2301
A	HOH2302
A	HOH2484

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 1616

Chain	Residue
A	HOH2228
A	HOH2448
A	HOH2449
A	HOH2594
A	ASP477
A	ASP485

---

site_id	AC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE PE4 A 1617

Chain	Residue
A	TYR317
A	LYS370
A	SER373
A	GLU384
A	TYR386
A	GLY445
A	HOH2354

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 1618

Chain	Residue
A	ARG196
A	TYR482
A	TRP517
A	ASP519
A	HOH2026
A	HOH2302

---

site_id	AC5
Number of Residues	8
Details	BINDING SITE FOR RESIDUE EDO A 1619

Chain	Residue
A	ASP360
A	GLU361
A	PHE415
A	TRP439
A	TYR469
A	TRP517
A	HOH2213
A	HOH2300

---

site_id	AC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE IOD A 1620

Chain	Residue
A	GLU543
A	HOH2012

---

site_id	AC7
Number of Residues	1
Details	BINDING SITE FOR RESIDUE IOD A 1621

Chain	Residue
A	LYS210

---

site_id	AC8
Number of Residues	1
Details	BINDING SITE FOR RESIDUE IOD A 1622

Chain	Residue
A	GLU503

---

site_id	AC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE IOD A 1623

Chain	Residue
A	PRO521
A	SER522

---

site_id	BC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE IOD A 1624

Chain	Residue
A	LYS452
A	GLU456

---

site_id	BC2
Number of Residues	1
Details	BINDING SITE FOR RESIDUE IOD A 1625

Chain	Residue
A	HOH2165

---

site_id	BC3
Number of Residues	1
Details	BINDING SITE FOR RESIDUE IOD A 1627

Chain	Residue
A	ASN609

---

site_id	BC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE IOD A 1628

Chain	Residue
A	ASP400
A	HOH2368

---

site_id	BC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE IOD A 1629

Chain	Residue
A	LYS306
A	ASN312
A	ASN489
A	ASN493
A	IOD1656
A	HOH2460

---

site_id	BC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE IOD A 1630

Chain	Residue
A	THR497
A	SER498

---

site_id	BC7
Number of Residues	1
Details	BINDING SITE FOR RESIDUE IOD A 1631

Chain	Residue
A	THR595

---

site_id	BC8
Number of Residues	1
Details	BINDING SITE FOR RESIDUE IOD A 1632

Chain	Residue
A	HOH2365

---

site_id	BC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE IOD A 1633

Chain	Residue
A	ARG524
A	HOH2445

---

site_id	CC1
Number of Residues	1
Details	BINDING SITE FOR RESIDUE IOD A 1634

Chain	Residue
A	LYS205

---

site_id	CC2
Number of Residues	1
Details	BINDING SITE FOR RESIDUE IOD A 1636

Chain	Residue
A	LYS501

---

site_id	CC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE IOD A 1637

Chain	Residue
A	ARG524
A	ARG529

---

site_id	CC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE IOD A 1639

Chain	Residue
A	ASN539
A	ARG590

---

site_id	CC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE IOD A 1640

Chain	Residue
A	ARG524
A	SER526
A	SER528

---

site_id	CC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE IOD A 1641

Chain	Residue
A	PRO508
A	ILE509
A	LYS579
A	IOD1642
A	HOH2019
A	HOH2338

---

site_id	CC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE IOD A 1642

Chain	Residue
A	LYS186
A	IOD1641
A	HOH2019

---

site_id	CC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE IOD A 1643

Chain	Residue
A	GLN311
A	HOH2230
A	HOH2450

---

site_id	CC9
Number of Residues	1
Details	BINDING SITE FOR RESIDUE IOD A 1645

Chain	Residue
A	ASN399

---

site_id	DC1
Number of Residues	1
Details	BINDING SITE FOR RESIDUE IOD A 1646

Chain	Residue
A	GLN332

---

site_id	DC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE IOD A 1647

Chain	Residue
A	GLU202
A	HOH2096

---

site_id	DC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE IOD A 1648

Chain	Residue
A	ARG324
A	ASN364
A	HOH2299

---

site_id	DC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE IOD A 1649

Chain	Residue
A	GLY445
A	ASP447
A	HOH2148
A	HOH2416

---

site_id	DC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE IOD A 1650

Chain	Residue
A	SER583
A	HOH2086

---

site_id	DC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE IOD A 1651

Chain	Residue
A	GLU353
A	HOH2294
A	IOD9010

---

site_id	DC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE IOD A 1652

Chain	Residue
A	GLU254
A	HOH2160

---

site_id	DC8
Number of Residues	1
Details	BINDING SITE FOR RESIDUE IOD A 1653

Chain	Residue
A	ASN258

---

site_id	DC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE IOD A 1654

Chain	Residue
A	HOH2262
A	GLU569

---

site_id	EC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE IOD A 1655

Chain	Residue
A	GLN460
A	GLU576

---

site_id	EC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE IOD A 1656

Chain	Residue
A	ASN312
A	ASN314
A	LYS321
A	IOD1629
A	HOH2232
A	HOH2466

---

site_id	EC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE IOD A 1657

Chain	Residue
A	GLN203
A	PRO527
A	IOD1662
A	HOH2298
A	HOH2488

---

site_id	EC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE IOD A 1658

Chain	Residue
A	THR567

---

site_id	EC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE IOD A 1659

Chain	Residue
A	GLU206
A	IOD1662

---

site_id	EC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE IOD A 1660

Chain	Residue
A	ALA568
A	HOH2403

---

site_id	EC7
Number of Residues	1
Details	BINDING SITE FOR RESIDUE IOD A 1661

Chain	Residue
A	ARG251

---

site_id	EC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE IOD A 1662

Chain	Residue
A	GLU206
A	IOD1657
A	IOD1659
A	HOH2038

---

site_id	EC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE IOD A 1665

Chain	Residue
A	ASN422
A	SER423
A	VAL448

---

site_id	FC1
Number of Residues	1
Details	BINDING SITE FOR RESIDUE IOD A 1666

Chain	Residue
A	HOH2540

---

site_id	FC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE IOD A 1667

Chain	Residue
A	ASP594
A	HOH2572
A	IOD9009

---

site_id	FC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE IOD A 1668

Chain	Residue
A	LYS197
A	ASN265
A	TYR525

---

site_id	FC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE IOD A 1669

Chain	Residue
A	LYS411
A	LYS575
A	HOH2546
A	IOD9011

---

site_id	FC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE IOD A 1670

Chain	Residue
A	MET180
A	ASN181
A	HOH2002
A	HOH2006
A	HOH2007

---

site_id	FC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE IOD A 1671

Chain	Residue
A	ASN539
A	IOD9005

---

site_id	FC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE IOD A 1672

Chain	Residue
A	GLY241
A	ARG565

---

site_id	FC8
Number of Residues	1
Details	BINDING SITE FOR RESIDUE IOD A 9001

Chain	Residue
A	LEU612

---

site_id	FC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE IOD A 9005

Chain	Residue
A	IOD1671
A	HOH2280
A	HOH2495

---

site_id	GC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE IOD A 9006

Chain	Residue
A	HOH2179
A	HOH2217
A	HOH2281

---

site_id	GC2
Number of Residues	1
Details	BINDING SITE FOR RESIDUE IOD A 9007

Chain	Residue
A	HOH2082

---

site_id	GC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE IOD A 9009

Chain	Residue
A	IOD1667
A	HOH2352

---

site_id	GC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE IOD A 9010

Chain	Residue
A	IOD1651
A	IOD9011

---

site_id	GC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE IOD A 9011

Chain	Residue
A	IOD1669
A	HOH2546
A	IOD9010

---

site_id	GC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE IOD A 9013

Chain	Residue
A	LYS406
A	ASP562
A	HOH2373
A	HOH2534

---