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2YGD

Molecular architectures of the 24meric eye lens chaperone alphaB- crystallin elucidated by a triple hybrid approach

Functional Information from GO Data
ChainGOidnamespacecontents
A0001540molecular_functionamyloid-beta binding
A0001666biological_processresponse to hypoxia
A0002088biological_processlens development in camera-type eye
A0005198molecular_functionstructural molecule activity
A0005212molecular_functionstructural constituent of eye lens
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005764cellular_componentlysosome
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0006457biological_processprotein folding
A0006936biological_processmuscle contraction
A0007021biological_processtubulin complex assembly
A0007517biological_processmuscle organ development
A0008017molecular_functionmicrotubule binding
A0008092molecular_functioncytoskeletal protein binding
A0009408biological_processresponse to heat
A0009986cellular_componentcell surface
A0010629biological_processnegative regulation of gene expression
A0030018cellular_componentZ disc
A0030308biological_processnegative regulation of cell growth
A0030424cellular_componentaxon
A0031109biological_processmicrotubule polymerization or depolymerization
A0031333biological_processnegative regulation of protein-containing complex assembly
A0031430cellular_componentM band
A0031674cellular_componentI band
A0032355biological_processresponse to estradiol
A0032387biological_processnegative regulation of intracellular transport
A0032432cellular_componentactin filament bundle
A0032991cellular_componentprotein-containing complex
A0042026biological_processprotein refolding
A0042542biological_processresponse to hydrogen peroxide
A0042802molecular_functionidentical protein binding
A0042803molecular_functionprotein homodimerization activity
A0043010biological_processcamera-type eye development
A0043066biological_processnegative regulation of apoptotic process
A0043067biological_processregulation of programmed cell death
A0043197cellular_componentdendritic spine
A0043204cellular_componentperikaryon
A0043292cellular_componentcontractile muscle fiber
A0044877molecular_functionprotein-containing complex binding
A0045892biological_processnegative regulation of DNA-templated transcription
A0046872molecular_functionmetal ion binding
A0050821biological_processprotein stabilization
A0051082molecular_functionunfolded protein binding
A0051403biological_processstress-activated MAPK cascade
A0060561biological_processapoptotic process involved in morphogenesis
A0070062cellular_componentextracellular exosome
A0071480biological_processcellular response to gamma radiation
A0097060cellular_componentsynaptic membrane
A0097512cellular_componentcardiac myofibril
A1905907biological_processnegative regulation of amyloid fibril formation
A2000378biological_processnegative regulation of reactive oxygen species metabolic process
B0001540molecular_functionamyloid-beta binding
B0001666biological_processresponse to hypoxia
B0002088biological_processlens development in camera-type eye
B0005198molecular_functionstructural molecule activity
B0005212molecular_functionstructural constituent of eye lens
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005764cellular_componentlysosome
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0006457biological_processprotein folding
B0006936biological_processmuscle contraction
B0007021biological_processtubulin complex assembly
B0007517biological_processmuscle organ development
B0008017molecular_functionmicrotubule binding
B0008092molecular_functioncytoskeletal protein binding
B0009408biological_processresponse to heat
B0009986cellular_componentcell surface
B0010629biological_processnegative regulation of gene expression
B0030018cellular_componentZ disc
B0030308biological_processnegative regulation of cell growth
B0030424cellular_componentaxon
B0031109biological_processmicrotubule polymerization or depolymerization
B0031333biological_processnegative regulation of protein-containing complex assembly
B0031430cellular_componentM band
B0031674cellular_componentI band
B0032355biological_processresponse to estradiol
B0032387biological_processnegative regulation of intracellular transport
B0032432cellular_componentactin filament bundle
B0032991cellular_componentprotein-containing complex
B0042026biological_processprotein refolding
B0042542biological_processresponse to hydrogen peroxide
B0042802molecular_functionidentical protein binding
B0042803molecular_functionprotein homodimerization activity
B0043010biological_processcamera-type eye development
B0043066biological_processnegative regulation of apoptotic process
B0043067biological_processregulation of programmed cell death
B0043197cellular_componentdendritic spine
B0043204cellular_componentperikaryon
B0043292cellular_componentcontractile muscle fiber
B0044877molecular_functionprotein-containing complex binding
B0045892biological_processnegative regulation of DNA-templated transcription
B0046872molecular_functionmetal ion binding
B0050821biological_processprotein stabilization
B0051082molecular_functionunfolded protein binding
B0051403biological_processstress-activated MAPK cascade
B0060561biological_processapoptotic process involved in morphogenesis
B0070062cellular_componentextracellular exosome
B0071480biological_processcellular response to gamma radiation
B0097060cellular_componentsynaptic membrane
B0097512cellular_componentcardiac myofibril
B1905907biological_processnegative regulation of amyloid fibril formation
B2000378biological_processnegative regulation of reactive oxygen species metabolic process
C0001540molecular_functionamyloid-beta binding
C0001666biological_processresponse to hypoxia
C0002088biological_processlens development in camera-type eye
C0005198molecular_functionstructural molecule activity
C0005212molecular_functionstructural constituent of eye lens
C0005515molecular_functionprotein binding
C0005576cellular_componentextracellular region
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005737cellular_componentcytoplasm
C0005739cellular_componentmitochondrion
C0005764cellular_componentlysosome
C0005829cellular_componentcytosol
C0005886cellular_componentplasma membrane
C0006457biological_processprotein folding
C0006936biological_processmuscle contraction
C0007021biological_processtubulin complex assembly
C0007517biological_processmuscle organ development
C0008017molecular_functionmicrotubule binding
C0008092molecular_functioncytoskeletal protein binding
C0009408biological_processresponse to heat
C0009986cellular_componentcell surface
C0010629biological_processnegative regulation of gene expression
C0030018cellular_componentZ disc
C0030308biological_processnegative regulation of cell growth
C0030424cellular_componentaxon
C0031109biological_processmicrotubule polymerization or depolymerization
C0031333biological_processnegative regulation of protein-containing complex assembly
C0031430cellular_componentM band
C0031674cellular_componentI band
C0032355biological_processresponse to estradiol
C0032387biological_processnegative regulation of intracellular transport
C0032432cellular_componentactin filament bundle
C0032991cellular_componentprotein-containing complex
C0042026biological_processprotein refolding
C0042542biological_processresponse to hydrogen peroxide
C0042802molecular_functionidentical protein binding
C0042803molecular_functionprotein homodimerization activity
C0043010biological_processcamera-type eye development
C0043066biological_processnegative regulation of apoptotic process
C0043067biological_processregulation of programmed cell death
C0043197cellular_componentdendritic spine
C0043204cellular_componentperikaryon
C0043292cellular_componentcontractile muscle fiber
C0044877molecular_functionprotein-containing complex binding
C0045892biological_processnegative regulation of DNA-templated transcription
C0046872molecular_functionmetal ion binding
C0050821biological_processprotein stabilization
C0051082molecular_functionunfolded protein binding
C0051403biological_processstress-activated MAPK cascade
C0060561biological_processapoptotic process involved in morphogenesis
C0070062cellular_componentextracellular exosome
C0071480biological_processcellular response to gamma radiation
C0097060cellular_componentsynaptic membrane
C0097512cellular_componentcardiac myofibril
C1905907biological_processnegative regulation of amyloid fibril formation
C2000378biological_processnegative regulation of reactive oxygen species metabolic process
D0001540molecular_functionamyloid-beta binding
D0001666biological_processresponse to hypoxia
D0002088biological_processlens development in camera-type eye
D0005198molecular_functionstructural molecule activity
D0005212molecular_functionstructural constituent of eye lens
D0005515molecular_functionprotein binding
D0005576cellular_componentextracellular region
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005737cellular_componentcytoplasm
D0005739cellular_componentmitochondrion
D0005764cellular_componentlysosome
D0005829cellular_componentcytosol
D0005886cellular_componentplasma membrane
D0006457biological_processprotein folding
D0006936biological_processmuscle contraction
D0007021biological_processtubulin complex assembly
D0007517biological_processmuscle organ development
D0008017molecular_functionmicrotubule binding
D0008092molecular_functioncytoskeletal protein binding
D0009408biological_processresponse to heat
D0009986cellular_componentcell surface
D0010629biological_processnegative regulation of gene expression
D0030018cellular_componentZ disc
D0030308biological_processnegative regulation of cell growth
D0030424cellular_componentaxon
D0031109biological_processmicrotubule polymerization or depolymerization
D0031333biological_processnegative regulation of protein-containing complex assembly
D0031430cellular_componentM band
D0031674cellular_componentI band
D0032355biological_processresponse to estradiol
D0032387biological_processnegative regulation of intracellular transport
D0032432cellular_componentactin filament bundle
D0032991cellular_componentprotein-containing complex
D0042026biological_processprotein refolding
D0042542biological_processresponse to hydrogen peroxide
D0042802molecular_functionidentical protein binding
D0042803molecular_functionprotein homodimerization activity
D0043010biological_processcamera-type eye development
D0043066biological_processnegative regulation of apoptotic process
D0043067biological_processregulation of programmed cell death
D0043197cellular_componentdendritic spine
D0043204cellular_componentperikaryon
D0043292cellular_componentcontractile muscle fiber
D0044877molecular_functionprotein-containing complex binding
D0045892biological_processnegative regulation of DNA-templated transcription
D0046872molecular_functionmetal ion binding
D0050821biological_processprotein stabilization
D0051082molecular_functionunfolded protein binding
D0051403biological_processstress-activated MAPK cascade
D0060561biological_processapoptotic process involved in morphogenesis
D0070062cellular_componentextracellular exosome
D0071480biological_processcellular response to gamma radiation
D0097060cellular_componentsynaptic membrane
D0097512cellular_componentcardiac myofibril
D1905907biological_processnegative regulation of amyloid fibril formation
D2000378biological_processnegative regulation of reactive oxygen species metabolic process
E0001540molecular_functionamyloid-beta binding
E0001666biological_processresponse to hypoxia
E0002088biological_processlens development in camera-type eye
E0005198molecular_functionstructural molecule activity
E0005212molecular_functionstructural constituent of eye lens
E0005515molecular_functionprotein binding
E0005576cellular_componentextracellular region
E0005634cellular_componentnucleus
E0005654cellular_componentnucleoplasm
E0005737cellular_componentcytoplasm
E0005739cellular_componentmitochondrion
E0005764cellular_componentlysosome
E0005829cellular_componentcytosol
E0005886cellular_componentplasma membrane
E0006457biological_processprotein folding
E0006936biological_processmuscle contraction
E0007021biological_processtubulin complex assembly
E0007517biological_processmuscle organ development
E0008017molecular_functionmicrotubule binding
E0008092molecular_functioncytoskeletal protein binding
E0009408biological_processresponse to heat
E0009986cellular_componentcell surface
E0010629biological_processnegative regulation of gene expression
E0030018cellular_componentZ disc
E0030308biological_processnegative regulation of cell growth
E0030424cellular_componentaxon
E0031109biological_processmicrotubule polymerization or depolymerization
E0031333biological_processnegative regulation of protein-containing complex assembly
E0031430cellular_componentM band
E0031674cellular_componentI band
E0032355biological_processresponse to estradiol
E0032387biological_processnegative regulation of intracellular transport
E0032432cellular_componentactin filament bundle
E0032991cellular_componentprotein-containing complex
E0042026biological_processprotein refolding
E0042542biological_processresponse to hydrogen peroxide
E0042802molecular_functionidentical protein binding
E0042803molecular_functionprotein homodimerization activity
E0043010biological_processcamera-type eye development
E0043066biological_processnegative regulation of apoptotic process
E0043067biological_processregulation of programmed cell death
E0043197cellular_componentdendritic spine
E0043204cellular_componentperikaryon
E0043292cellular_componentcontractile muscle fiber
E0044877molecular_functionprotein-containing complex binding
E0045892biological_processnegative regulation of DNA-templated transcription
E0046872molecular_functionmetal ion binding
E0050821biological_processprotein stabilization
E0051082molecular_functionunfolded protein binding
E0051403biological_processstress-activated MAPK cascade
E0060561biological_processapoptotic process involved in morphogenesis
E0070062cellular_componentextracellular exosome
E0071480biological_processcellular response to gamma radiation
E0097060cellular_componentsynaptic membrane
E0097512cellular_componentcardiac myofibril
E1905907biological_processnegative regulation of amyloid fibril formation
E2000378biological_processnegative regulation of reactive oxygen species metabolic process
F0001540molecular_functionamyloid-beta binding
F0001666biological_processresponse to hypoxia
F0002088biological_processlens development in camera-type eye
F0005198molecular_functionstructural molecule activity
F0005212molecular_functionstructural constituent of eye lens
F0005515molecular_functionprotein binding
F0005576cellular_componentextracellular region
F0005634cellular_componentnucleus
F0005654cellular_componentnucleoplasm
F0005737cellular_componentcytoplasm
F0005739cellular_componentmitochondrion
F0005764cellular_componentlysosome
F0005829cellular_componentcytosol
F0005886cellular_componentplasma membrane
F0006457biological_processprotein folding
F0006936biological_processmuscle contraction
F0007021biological_processtubulin complex assembly
F0007517biological_processmuscle organ development
F0008017molecular_functionmicrotubule binding
F0008092molecular_functioncytoskeletal protein binding
F0009408biological_processresponse to heat
F0009986cellular_componentcell surface
F0010629biological_processnegative regulation of gene expression
F0030018cellular_componentZ disc
F0030308biological_processnegative regulation of cell growth
F0030424cellular_componentaxon
F0031109biological_processmicrotubule polymerization or depolymerization
F0031333biological_processnegative regulation of protein-containing complex assembly
F0031430cellular_componentM band
F0031674cellular_componentI band
F0032355biological_processresponse to estradiol
F0032387biological_processnegative regulation of intracellular transport
F0032432cellular_componentactin filament bundle
F0032991cellular_componentprotein-containing complex
F0042026biological_processprotein refolding
F0042542biological_processresponse to hydrogen peroxide
F0042802molecular_functionidentical protein binding
F0042803molecular_functionprotein homodimerization activity
F0043010biological_processcamera-type eye development
F0043066biological_processnegative regulation of apoptotic process
F0043067biological_processregulation of programmed cell death
F0043197cellular_componentdendritic spine
F0043204cellular_componentperikaryon
F0043292cellular_componentcontractile muscle fiber
F0044877molecular_functionprotein-containing complex binding
F0045892biological_processnegative regulation of DNA-templated transcription
F0046872molecular_functionmetal ion binding
F0050821biological_processprotein stabilization
F0051082molecular_functionunfolded protein binding
F0051403biological_processstress-activated MAPK cascade
F0060561biological_processapoptotic process involved in morphogenesis
F0070062cellular_componentextracellular exosome
F0071480biological_processcellular response to gamma radiation
F0097060cellular_componentsynaptic membrane
F0097512cellular_componentcardiac myofibril
F1905907biological_processnegative regulation of amyloid fibril formation
F2000378biological_processnegative regulation of reactive oxygen species metabolic process
G0001540molecular_functionamyloid-beta binding
G0001666biological_processresponse to hypoxia
G0002088biological_processlens development in camera-type eye
G0005198molecular_functionstructural molecule activity
G0005212molecular_functionstructural constituent of eye lens
G0005515molecular_functionprotein binding
G0005576cellular_componentextracellular region
G0005634cellular_componentnucleus
G0005654cellular_componentnucleoplasm
G0005737cellular_componentcytoplasm
G0005739cellular_componentmitochondrion
G0005764cellular_componentlysosome
G0005829cellular_componentcytosol
G0005886cellular_componentplasma membrane
G0006457biological_processprotein folding
G0006936biological_processmuscle contraction
G0007021biological_processtubulin complex assembly
G0007517biological_processmuscle organ development
G0008017molecular_functionmicrotubule binding
G0008092molecular_functioncytoskeletal protein binding
G0009408biological_processresponse to heat
G0009986cellular_componentcell surface
G0010629biological_processnegative regulation of gene expression
G0030018cellular_componentZ disc
G0030308biological_processnegative regulation of cell growth
G0030424cellular_componentaxon
G0031109biological_processmicrotubule polymerization or depolymerization
G0031333biological_processnegative regulation of protein-containing complex assembly
G0031430cellular_componentM band
G0031674cellular_componentI band
G0032355biological_processresponse to estradiol
G0032387biological_processnegative regulation of intracellular transport
G0032432cellular_componentactin filament bundle
G0032991cellular_componentprotein-containing complex
G0042026biological_processprotein refolding
G0042542biological_processresponse to hydrogen peroxide
G0042802molecular_functionidentical protein binding
G0042803molecular_functionprotein homodimerization activity
G0043010biological_processcamera-type eye development
G0043066biological_processnegative regulation of apoptotic process
G0043067biological_processregulation of programmed cell death
G0043197cellular_componentdendritic spine
G0043204cellular_componentperikaryon
G0043292cellular_componentcontractile muscle fiber
G0044877molecular_functionprotein-containing complex binding
G0045892biological_processnegative regulation of DNA-templated transcription
G0046872molecular_functionmetal ion binding
G0050821biological_processprotein stabilization
G0051082molecular_functionunfolded protein binding
G0051403biological_processstress-activated MAPK cascade
G0060561biological_processapoptotic process involved in morphogenesis
G0070062cellular_componentextracellular exosome
G0071480biological_processcellular response to gamma radiation
G0097060cellular_componentsynaptic membrane
G0097512cellular_componentcardiac myofibril
G1905907biological_processnegative regulation of amyloid fibril formation
G2000378biological_processnegative regulation of reactive oxygen species metabolic process
H0001540molecular_functionamyloid-beta binding
H0001666biological_processresponse to hypoxia
H0002088biological_processlens development in camera-type eye
H0005198molecular_functionstructural molecule activity
H0005212molecular_functionstructural constituent of eye lens
H0005515molecular_functionprotein binding
H0005576cellular_componentextracellular region
H0005634cellular_componentnucleus
H0005654cellular_componentnucleoplasm
H0005737cellular_componentcytoplasm
H0005739cellular_componentmitochondrion
H0005764cellular_componentlysosome
H0005829cellular_componentcytosol
H0005886cellular_componentplasma membrane
H0006457biological_processprotein folding
H0006936biological_processmuscle contraction
H0007021biological_processtubulin complex assembly
H0007517biological_processmuscle organ development
H0008017molecular_functionmicrotubule binding
H0008092molecular_functioncytoskeletal protein binding
H0009408biological_processresponse to heat
H0009986cellular_componentcell surface
H0010629biological_processnegative regulation of gene expression
H0030018cellular_componentZ disc
H0030308biological_processnegative regulation of cell growth
H0030424cellular_componentaxon
H0031109biological_processmicrotubule polymerization or depolymerization
H0031333biological_processnegative regulation of protein-containing complex assembly
H0031430cellular_componentM band
H0031674cellular_componentI band
H0032355biological_processresponse to estradiol
H0032387biological_processnegative regulation of intracellular transport
H0032432cellular_componentactin filament bundle
H0032991cellular_componentprotein-containing complex
H0042026biological_processprotein refolding
H0042542biological_processresponse to hydrogen peroxide
H0042802molecular_functionidentical protein binding
H0042803molecular_functionprotein homodimerization activity
H0043010biological_processcamera-type eye development
H0043066biological_processnegative regulation of apoptotic process
H0043067biological_processregulation of programmed cell death
H0043197cellular_componentdendritic spine
H0043204cellular_componentperikaryon
H0043292cellular_componentcontractile muscle fiber
H0044877molecular_functionprotein-containing complex binding
H0045892biological_processnegative regulation of DNA-templated transcription
H0046872molecular_functionmetal ion binding
H0050821biological_processprotein stabilization
H0051082molecular_functionunfolded protein binding
H0051403biological_processstress-activated MAPK cascade
H0060561biological_processapoptotic process involved in morphogenesis
H0070062cellular_componentextracellular exosome
H0071480biological_processcellular response to gamma radiation
H0097060cellular_componentsynaptic membrane
H0097512cellular_componentcardiac myofibril
H1905907biological_processnegative regulation of amyloid fibril formation
H2000378biological_processnegative regulation of reactive oxygen species metabolic process
I0001540molecular_functionamyloid-beta binding
I0001666biological_processresponse to hypoxia
I0002088biological_processlens development in camera-type eye
I0005198molecular_functionstructural molecule activity
I0005212molecular_functionstructural constituent of eye lens
I0005515molecular_functionprotein binding
I0005576cellular_componentextracellular region
I0005634cellular_componentnucleus
I0005654cellular_componentnucleoplasm
I0005737cellular_componentcytoplasm
I0005739cellular_componentmitochondrion
I0005764cellular_componentlysosome
I0005829cellular_componentcytosol
I0005886cellular_componentplasma membrane
I0006457biological_processprotein folding
I0006936biological_processmuscle contraction
I0007021biological_processtubulin complex assembly
I0007517biological_processmuscle organ development
I0008017molecular_functionmicrotubule binding
I0008092molecular_functioncytoskeletal protein binding
I0009408biological_processresponse to heat
I0009986cellular_componentcell surface
I0010629biological_processnegative regulation of gene expression
I0030018cellular_componentZ disc
I0030308biological_processnegative regulation of cell growth
I0030424cellular_componentaxon
I0031109biological_processmicrotubule polymerization or depolymerization
I0031333biological_processnegative regulation of protein-containing complex assembly
I0031430cellular_componentM band
I0031674cellular_componentI band
I0032355biological_processresponse to estradiol
I0032387biological_processnegative regulation of intracellular transport
I0032432cellular_componentactin filament bundle
I0032991cellular_componentprotein-containing complex
I0042026biological_processprotein refolding
I0042542biological_processresponse to hydrogen peroxide
I0042802molecular_functionidentical protein binding
I0042803molecular_functionprotein homodimerization activity
I0043010biological_processcamera-type eye development
I0043066biological_processnegative regulation of apoptotic process
I0043067biological_processregulation of programmed cell death
I0043197cellular_componentdendritic spine
I0043204cellular_componentperikaryon
I0043292cellular_componentcontractile muscle fiber
I0044877molecular_functionprotein-containing complex binding
I0045892biological_processnegative regulation of DNA-templated transcription
I0046872molecular_functionmetal ion binding
I0050821biological_processprotein stabilization
I0051082molecular_functionunfolded protein binding
I0051403biological_processstress-activated MAPK cascade
I0060561biological_processapoptotic process involved in morphogenesis
I0070062cellular_componentextracellular exosome
I0071480biological_processcellular response to gamma radiation
I0097060cellular_componentsynaptic membrane
I0097512cellular_componentcardiac myofibril
I1905907biological_processnegative regulation of amyloid fibril formation
I2000378biological_processnegative regulation of reactive oxygen species metabolic process
J0001540molecular_functionamyloid-beta binding
J0001666biological_processresponse to hypoxia
J0002088biological_processlens development in camera-type eye
J0005198molecular_functionstructural molecule activity
J0005212molecular_functionstructural constituent of eye lens
J0005515molecular_functionprotein binding
J0005576cellular_componentextracellular region
J0005634cellular_componentnucleus
J0005654cellular_componentnucleoplasm
J0005737cellular_componentcytoplasm
J0005739cellular_componentmitochondrion
J0005764cellular_componentlysosome
J0005829cellular_componentcytosol
J0005886cellular_componentplasma membrane
J0006457biological_processprotein folding
J0006936biological_processmuscle contraction
J0007021biological_processtubulin complex assembly
J0007517biological_processmuscle organ development
J0008017molecular_functionmicrotubule binding
J0008092molecular_functioncytoskeletal protein binding
J0009408biological_processresponse to heat
J0009986cellular_componentcell surface
J0010629biological_processnegative regulation of gene expression
J0030018cellular_componentZ disc
J0030308biological_processnegative regulation of cell growth
J0030424cellular_componentaxon
J0031109biological_processmicrotubule polymerization or depolymerization
J0031333biological_processnegative regulation of protein-containing complex assembly
J0031430cellular_componentM band
J0031674cellular_componentI band
J0032355biological_processresponse to estradiol
J0032387biological_processnegative regulation of intracellular transport
J0032432cellular_componentactin filament bundle
J0032991cellular_componentprotein-containing complex
J0042026biological_processprotein refolding
J0042542biological_processresponse to hydrogen peroxide
J0042802molecular_functionidentical protein binding
J0042803molecular_functionprotein homodimerization activity
J0043010biological_processcamera-type eye development
J0043066biological_processnegative regulation of apoptotic process
J0043067biological_processregulation of programmed cell death
J0043197cellular_componentdendritic spine
J0043204cellular_componentperikaryon
J0043292cellular_componentcontractile muscle fiber
J0044877molecular_functionprotein-containing complex binding
J0045892biological_processnegative regulation of DNA-templated transcription
J0046872molecular_functionmetal ion binding
J0050821biological_processprotein stabilization
J0051082molecular_functionunfolded protein binding
J0051403biological_processstress-activated MAPK cascade
J0060561biological_processapoptotic process involved in morphogenesis
J0070062cellular_componentextracellular exosome
J0071480biological_processcellular response to gamma radiation
J0097060cellular_componentsynaptic membrane
J0097512cellular_componentcardiac myofibril
J1905907biological_processnegative regulation of amyloid fibril formation
J2000378biological_processnegative regulation of reactive oxygen species metabolic process
K0001540molecular_functionamyloid-beta binding
K0001666biological_processresponse to hypoxia
K0002088biological_processlens development in camera-type eye
K0005198molecular_functionstructural molecule activity
K0005212molecular_functionstructural constituent of eye lens
K0005515molecular_functionprotein binding
K0005576cellular_componentextracellular region
K0005634cellular_componentnucleus
K0005654cellular_componentnucleoplasm
K0005737cellular_componentcytoplasm
K0005739cellular_componentmitochondrion
K0005764cellular_componentlysosome
K0005829cellular_componentcytosol
K0005886cellular_componentplasma membrane
K0006457biological_processprotein folding
K0006936biological_processmuscle contraction
K0007021biological_processtubulin complex assembly
K0007517biological_processmuscle organ development
K0008017molecular_functionmicrotubule binding
K0008092molecular_functioncytoskeletal protein binding
K0009408biological_processresponse to heat
K0009986cellular_componentcell surface
K0010629biological_processnegative regulation of gene expression
K0030018cellular_componentZ disc
K0030308biological_processnegative regulation of cell growth
K0030424cellular_componentaxon
K0031109biological_processmicrotubule polymerization or depolymerization
K0031333biological_processnegative regulation of protein-containing complex assembly
K0031430cellular_componentM band
K0031674cellular_componentI band
K0032355biological_processresponse to estradiol
K0032387biological_processnegative regulation of intracellular transport
K0032432cellular_componentactin filament bundle
K0032991cellular_componentprotein-containing complex
K0042026biological_processprotein refolding
K0042542biological_processresponse to hydrogen peroxide
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V0007021biological_processtubulin complex assembly
V0007517biological_processmuscle organ development
V0008017molecular_functionmicrotubule binding
V0008092molecular_functioncytoskeletal protein binding
V0009408biological_processresponse to heat
V0009986cellular_componentcell surface
V0010629biological_processnegative regulation of gene expression
V0030018cellular_componentZ disc
V0030308biological_processnegative regulation of cell growth
V0030424cellular_componentaxon
V0031109biological_processmicrotubule polymerization or depolymerization
V0031333biological_processnegative regulation of protein-containing complex assembly
V0031430cellular_componentM band
V0031674cellular_componentI band
V0032355biological_processresponse to estradiol
V0032387biological_processnegative regulation of intracellular transport
V0032432cellular_componentactin filament bundle
V0032991cellular_componentprotein-containing complex
V0042026biological_processprotein refolding
V0042542biological_processresponse to hydrogen peroxide
V0042802molecular_functionidentical protein binding
V0042803molecular_functionprotein homodimerization activity
V0043010biological_processcamera-type eye development
V0043066biological_processnegative regulation of apoptotic process
V0043067biological_processregulation of programmed cell death
V0043197cellular_componentdendritic spine
V0043204cellular_componentperikaryon
V0043292cellular_componentcontractile muscle fiber
V0044877molecular_functionprotein-containing complex binding
V0045892biological_processnegative regulation of DNA-templated transcription
V0046872molecular_functionmetal ion binding
V0050821biological_processprotein stabilization
V0051082molecular_functionunfolded protein binding
V0051403biological_processstress-activated MAPK cascade
V0060561biological_processapoptotic process involved in morphogenesis
V0070062cellular_componentextracellular exosome
V0071480biological_processcellular response to gamma radiation
V0097060cellular_componentsynaptic membrane
V0097512cellular_componentcardiac myofibril
V1905907biological_processnegative regulation of amyloid fibril formation
V2000378biological_processnegative regulation of reactive oxygen species metabolic process
W0001540molecular_functionamyloid-beta binding
W0001666biological_processresponse to hypoxia
W0002088biological_processlens development in camera-type eye
W0005198molecular_functionstructural molecule activity
W0005212molecular_functionstructural constituent of eye lens
W0005515molecular_functionprotein binding
W0005576cellular_componentextracellular region
W0005634cellular_componentnucleus
W0005654cellular_componentnucleoplasm
W0005737cellular_componentcytoplasm
W0005739cellular_componentmitochondrion
W0005764cellular_componentlysosome
W0005829cellular_componentcytosol
W0005886cellular_componentplasma membrane
W0006457biological_processprotein folding
W0006936biological_processmuscle contraction
W0007021biological_processtubulin complex assembly
W0007517biological_processmuscle organ development
W0008017molecular_functionmicrotubule binding
W0008092molecular_functioncytoskeletal protein binding
W0009408biological_processresponse to heat
W0009986cellular_componentcell surface
W0010629biological_processnegative regulation of gene expression
W0030018cellular_componentZ disc
W0030308biological_processnegative regulation of cell growth
W0030424cellular_componentaxon
W0031109biological_processmicrotubule polymerization or depolymerization
W0031333biological_processnegative regulation of protein-containing complex assembly
W0031430cellular_componentM band
W0031674cellular_componentI band
W0032355biological_processresponse to estradiol
W0032387biological_processnegative regulation of intracellular transport
W0032432cellular_componentactin filament bundle
W0032991cellular_componentprotein-containing complex
W0042026biological_processprotein refolding
W0042542biological_processresponse to hydrogen peroxide
W0042802molecular_functionidentical protein binding
W0042803molecular_functionprotein homodimerization activity
W0043010biological_processcamera-type eye development
W0043066biological_processnegative regulation of apoptotic process
W0043067biological_processregulation of programmed cell death
W0043197cellular_componentdendritic spine
W0043204cellular_componentperikaryon
W0043292cellular_componentcontractile muscle fiber
W0044877molecular_functionprotein-containing complex binding
W0045892biological_processnegative regulation of DNA-templated transcription
W0046872molecular_functionmetal ion binding
W0050821biological_processprotein stabilization
W0051082molecular_functionunfolded protein binding
W0051403biological_processstress-activated MAPK cascade
W0060561biological_processapoptotic process involved in morphogenesis
W0070062cellular_componentextracellular exosome
W0071480biological_processcellular response to gamma radiation
W0097060cellular_componentsynaptic membrane
W0097512cellular_componentcardiac myofibril
W1905907biological_processnegative regulation of amyloid fibril formation
W2000378biological_processnegative regulation of reactive oxygen species metabolic process
X0001540molecular_functionamyloid-beta binding
X0001666biological_processresponse to hypoxia
X0002088biological_processlens development in camera-type eye
X0005198molecular_functionstructural molecule activity
X0005212molecular_functionstructural constituent of eye lens
X0005515molecular_functionprotein binding
X0005576cellular_componentextracellular region
X0005634cellular_componentnucleus
X0005654cellular_componentnucleoplasm
X0005737cellular_componentcytoplasm
X0005739cellular_componentmitochondrion
X0005764cellular_componentlysosome
X0005829cellular_componentcytosol
X0005886cellular_componentplasma membrane
X0006457biological_processprotein folding
X0006936biological_processmuscle contraction
X0007021biological_processtubulin complex assembly
X0007517biological_processmuscle organ development
X0008017molecular_functionmicrotubule binding
X0008092molecular_functioncytoskeletal protein binding
X0009408biological_processresponse to heat
X0009986cellular_componentcell surface
X0010629biological_processnegative regulation of gene expression
X0030018cellular_componentZ disc
X0030308biological_processnegative regulation of cell growth
X0030424cellular_componentaxon
X0031109biological_processmicrotubule polymerization or depolymerization
X0031333biological_processnegative regulation of protein-containing complex assembly
X0031430cellular_componentM band
X0031674cellular_componentI band
X0032355biological_processresponse to estradiol
X0032387biological_processnegative regulation of intracellular transport
X0032432cellular_componentactin filament bundle
X0032991cellular_componentprotein-containing complex
X0042026biological_processprotein refolding
X0042542biological_processresponse to hydrogen peroxide
X0042802molecular_functionidentical protein binding
X0042803molecular_functionprotein homodimerization activity
X0043010biological_processcamera-type eye development
X0043066biological_processnegative regulation of apoptotic process
X0043067biological_processregulation of programmed cell death
X0043197cellular_componentdendritic spine
X0043204cellular_componentperikaryon
X0043292cellular_componentcontractile muscle fiber
X0044877molecular_functionprotein-containing complex binding
X0045892biological_processnegative regulation of DNA-templated transcription
X0046872molecular_functionmetal ion binding
X0050821biological_processprotein stabilization
X0051082molecular_functionunfolded protein binding
X0051403biological_processstress-activated MAPK cascade
X0060561biological_processapoptotic process involved in morphogenesis
X0070062cellular_componentextracellular exosome
X0071480biological_processcellular response to gamma radiation
X0097060cellular_componentsynaptic membrane
X0097512cellular_componentcardiac myofibril
X1905907biological_processnegative regulation of amyloid fibril formation
X2000378biological_processnegative regulation of reactive oxygen species metabolic process
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues48
DetailsBINDING: BINDING => ECO:0000250
ChainResidueDetails
AHIS83
EGLU106
FHIS83
FGLU106
GHIS83
GGLU106
HHIS83
HGLU106
IHIS83
IGLU106
JHIS83
AGLU106
JGLU106
KHIS83
KGLU106
LHIS83
LGLU106
MHIS83
MGLU106
NHIS83
NGLU106
OHIS83
BHIS83
OGLU106
PHIS83
PGLU106
QHIS83
QGLU106
RHIS83
RGLU106
SHIS83
SGLU106
THIS83
BGLU106
TGLU106
UHIS83
UGLU106
VHIS83
VGLU106
WHIS83
WGLU106
XHIS83
XGLU106
CHIS83
CGLU106
DHIS83
DGLU106
EHIS83

site_idSWS_FT_FI2
Number of Residues72
DetailsBINDING: BINDING => ECO:0000305|PubMed:22890888
ChainResidueDetails
AHIS104
DHIS104
DHIS111
DHIS119
EHIS104
EHIS111
EHIS119
FHIS104
FHIS111
FHIS119
GHIS104
AHIS111
GHIS111
GHIS119
HHIS104
HHIS111
HHIS119
IHIS104
IHIS111
IHIS119
JHIS104
JHIS111
AHIS119
JHIS119
KHIS104
KHIS111
KHIS119
LHIS104
LHIS111
LHIS119
MHIS104
MHIS111
MHIS119
BHIS104
NHIS104
NHIS111
NHIS119
OHIS104
OHIS111
OHIS119
PHIS104
PHIS111
PHIS119
QHIS104
BHIS111
QHIS111
QHIS119
RHIS104
RHIS111
RHIS119
SHIS104
SHIS111
SHIS119
THIS104
THIS111
BHIS119
THIS119
UHIS104
UHIS111
UHIS119
VHIS104
VHIS111
VHIS119
WHIS104
WHIS111
WHIS119
CHIS104
XHIS104
XHIS111
XHIS119
CHIS111
CHIS119

site_idSWS_FT_FI3
Number of Residues72
DetailsSITE: Susceptible to oxidation
ChainResidueDetails
ATYR48
DTYR48
DTRP60
DMET68
ETYR48
ETRP60
EMET68
FTYR48
FTRP60
FMET68
GTYR48
ATRP60
GTRP60
GMET68
HTYR48
HTRP60
HMET68
ITYR48
ITRP60
IMET68
JTYR48
JTRP60
AMET68
JMET68
KTYR48
KTRP60
KMET68
LTYR48
LTRP60
LMET68
MTYR48
MTRP60
MMET68
BTYR48
NTYR48
NTRP60
NMET68
OTYR48
OTRP60
OMET68
PTYR48
PTRP60
PMET68
QTYR48
BTRP60
QTRP60
QMET68
RTYR48
RTRP60
RMET68
STYR48
STRP60
SMET68
TTYR48
TTRP60
BMET68
TMET68
UTYR48
UTRP60
UMET68
VTYR48
VTRP60
VMET68
WTYR48
WTRP60
WMET68
CTYR48
XTYR48
XTRP60
XMET68
CTRP60
CMET68

site_idSWS_FT_FI4
Number of Residues24
DetailsMOD_RES: N-acetylmethionine => ECO:0000269|PubMed:8142454, ECO:0000269|PubMed:838078
ChainResidueDetails
AMET1
JMET1
KMET1
LMET1
MMET1
NMET1
OMET1
PMET1
QMET1
RMET1
SMET1
BMET1
TMET1
UMET1
VMET1
WMET1
XMET1
CMET1
DMET1
EMET1
FMET1
GMET1
HMET1
IMET1

site_idSWS_FT_FI5
Number of Residues24
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:8175657
ChainResidueDetails
ASER19
JSER19
KSER19
LSER19
MSER19
NSER19
OSER19
PSER19
QSER19
RSER19
SSER19
BSER19
TSER19
USER19
VSER19
WSER19
XSER19
CSER19
DSER19
ESER19
FSER19
GSER19
HSER19
ISER19

site_idSWS_FT_FI6
Number of Residues24
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:11158243, ECO:0000269|PubMed:8175657
ChainResidueDetails
ASER45
JSER45
KSER45
LSER45
MSER45
NSER45
OSER45
PSER45
QSER45
RSER45
SSER45
BSER45
TSER45
USER45
VSER45
WSER45
XSER45
CSER45
DSER45
ESER45
FSER45
GSER45
HSER45
ISER45

site_idSWS_FT_FI7
Number of Residues24
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:11158243, ECO:0000269|PubMed:8175657, ECO:0007744|PubMed:24275569
ChainResidueDetails
ASER59
JSER59
KSER59
LSER59
MSER59
NSER59
OSER59
PSER59
QSER59
RSER59
SSER59
BSER59
TSER59
USER59
VSER59
WSER59
XSER59
CSER59
DSER59
ESER59
FSER59
GSER59
HSER59
ISER59

site_idSWS_FT_FI8
Number of Residues24
DetailsMOD_RES: N6-acetyllysine; partial => ECO:0000269|PubMed:11369851, ECO:0000269|PubMed:22120592
ChainResidueDetails
ALYS92
JLYS92
KLYS92
LLYS92
MLYS92
NLYS92
OLYS92
PLYS92
QLYS92
RLYS92
SLYS92
BLYS92
TLYS92
ULYS92
VLYS92
WLYS92
XLYS92
CLYS92
DLYS92
ELYS92
FLYS92
GLYS92
HLYS92
ILYS92

site_idSWS_FT_FI9
Number of Residues24
DetailsMOD_RES: N6-acetyllysine => ECO:0000269|PubMed:22120592
ChainResidueDetails
ALYS166
JLYS166
KLYS166
LLYS166
MLYS166
NLYS166
OLYS166
PLYS166
QLYS166
RLYS166
SLYS166
BLYS166
TLYS166
ULYS166
VLYS166
WLYS166
XLYS166
CLYS166
DLYS166
ELYS166
FLYS166
GLYS166
HLYS166
ILYS166

site_idSWS_FT_FI10
Number of Residues24
DetailsCARBOHYD: O-linked (GlcNAc) serine => ECO:0000269|PubMed:28939839
ChainResidueDetails
ASER41
JSER41
KSER41
LSER41
MSER41
NSER41
OSER41
PSER41
QSER41
RSER41
SSER41
BSER41
TSER41
USER41
VSER41
WSER41
XSER41
CSER41
DSER41
ESER41
FSER41
GSER41
HSER41
ISER41

site_idSWS_FT_FI11
Number of Residues24
DetailsCARBOHYD: O-linked (GlcNAc) threonine => ECO:0000250|UniProtKB:P23928
ChainResidueDetails
ATHR170
JTHR170
KTHR170
LTHR170
MTHR170
NTHR170
OTHR170
PTHR170
QTHR170
RTHR170
STHR170
BTHR170
TTHR170
UTHR170
VTHR170
WTHR170
XTHR170
CTHR170
DTHR170
ETHR170
FTHR170
GTHR170
HTHR170
ITHR170

219140

PDB entries from 2024-05-01

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