2YBU
Crystal structure of human acidic chitinase in complex with bisdionin F
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004553 | molecular_function | hydrolase activity, hydrolyzing O-glycosyl compounds |
| A | 0005975 | biological_process | carbohydrate metabolic process |
| A | 0008061 | molecular_function | chitin binding |
| B | 0004553 | molecular_function | hydrolase activity, hydrolyzing O-glycosyl compounds |
| B | 0005975 | biological_process | carbohydrate metabolic process |
| B | 0008061 | molecular_function | chitin binding |
| C | 0004553 | molecular_function | hydrolase activity, hydrolyzing O-glycosyl compounds |
| C | 0005975 | biological_process | carbohydrate metabolic process |
| C | 0008061 | molecular_function | chitin binding |
| D | 0004553 | molecular_function | hydrolase activity, hydrolyzing O-glycosyl compounds |
| D | 0005975 | biological_process | carbohydrate metabolic process |
| D | 0008061 | molecular_function | chitin binding |
| E | 0004553 | molecular_function | hydrolase activity, hydrolyzing O-glycosyl compounds |
| E | 0005975 | biological_process | carbohydrate metabolic process |
| E | 0008061 | molecular_function | chitin binding |
| F | 0004553 | molecular_function | hydrolase activity, hydrolyzing O-glycosyl compounds |
| F | 0005975 | biological_process | carbohydrate metabolic process |
| F | 0008061 | molecular_function | chitin binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 1397 |
| Chain | Residue |
| A | TRP31 |
| A | ARG35 |
| A | GLU297 |
| A | TRP360 |
| A | CX91398 |
| A | HOH2008 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL B 1397 |
| Chain | Residue |
| B | ILE300 |
| B | TRP360 |
| B | CX91398 |
| B | HOH2211 |
| B | TRP31 |
| B | ARG35 |
| B | GLU297 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL C 1397 |
| Chain | Residue |
| C | TRP31 |
| C | ARG35 |
| C | TRP360 |
| C | CX91398 |
| C | HOH2197 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL D 1397 |
| Chain | Residue |
| D | TRP31 |
| D | ARG35 |
| D | GLU297 |
| D | TRP360 |
| D | CX91398 |
| D | HOH2158 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL E 1397 |
| Chain | Residue |
| E | TRP31 |
| E | ARG35 |
| E | GLU297 |
| E | TRP360 |
| E | LEU364 |
| E | CX91398 |
| E | HOH2168 |
| site_id | AC6 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL F 1397 |
| Chain | Residue |
| F | TRP31 |
| F | ARG35 |
| F | GLU297 |
| F | ILE300 |
| F | TRP360 |
| F | LEU364 |
| F | CX91398 |
| F | HOH2113 |
| site_id | AC7 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE CX9 A 1398 |
| Chain | Residue |
| A | TRP31 |
| A | PHE58 |
| A | GLY98 |
| A | TRP99 |
| A | ASN100 |
| A | ASP138 |
| A | GLU140 |
| A | MET210 |
| A | TYR212 |
| A | TYR267 |
| A | TRP360 |
| A | GOL1397 |
| A | HOH2057 |
| A | HOH2129 |
| A | HOH2213 |
| site_id | AC8 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE CX9 B 1398 |
| Chain | Residue |
| B | TRP31 |
| B | PHE58 |
| B | GLY98 |
| B | TRP99 |
| B | ASN100 |
| B | ASP138 |
| B | GLU140 |
| B | MET210 |
| B | TYR212 |
| B | TYR267 |
| B | TRP360 |
| B | GOL1397 |
| B | HOH2059 |
| B | HOH2220 |
| site_id | AC9 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE CX9 C 1398 |
| Chain | Residue |
| C | TRP31 |
| C | PHE58 |
| C | GLY98 |
| C | TRP99 |
| C | ASN100 |
| C | ASP138 |
| C | GLU140 |
| C | MET210 |
| C | TYR212 |
| C | TYR267 |
| C | TRP360 |
| C | GOL1397 |
| C | HOH2198 |
| site_id | BC1 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE CX9 D 1398 |
| Chain | Residue |
| D | TRP31 |
| D | PHE58 |
| D | GLY98 |
| D | TRP99 |
| D | ASN100 |
| D | ASP138 |
| D | GLU140 |
| D | MET210 |
| D | TYR212 |
| D | TYR267 |
| D | TRP360 |
| D | GOL1397 |
| D | HOH2042 |
| D | HOH2170 |
| D | HOH2171 |
| site_id | BC2 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE CX9 E 1398 |
| Chain | Residue |
| E | TRP99 |
| E | ASN100 |
| E | ASP138 |
| E | GLU140 |
| E | MET210 |
| E | TYR212 |
| E | TYR267 |
| E | TRP360 |
| E | GOL1397 |
| E | HOH2193 |
| E | TRP31 |
| E | PHE58 |
| E | GLY98 |
| site_id | BC3 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE CX9 F 1398 |
| Chain | Residue |
| F | TRP31 |
| F | PHE58 |
| F | GLY98 |
| F | TRP99 |
| F | ASN100 |
| F | ASP138 |
| F | GLU140 |
| F | MET210 |
| F | TYR212 |
| F | TYR267 |
| F | TRP360 |
| F | GOL1397 |
| F | HOH2090 |
| F | HOH2123 |
| site_id | BC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CX9 A 1399 |
| Chain | Residue |
| A | TRP99 |
| A | TRP218 |
| A | HOH2086 |
| site_id | BC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CX9 B 1399 |
| Chain | Residue |
| B | TRP99 |
| B | TRP218 |
| site_id | BC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CX9 C 1399 |
| Chain | Residue |
| C | TRP99 |
| C | TRP218 |
| C | HOH2069 |
| C | HOH2199 |
| site_id | BC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CX9 D 1399 |
| Chain | Residue |
| A | GLN62 |
| D | TRP99 |
| D | TRP218 |
| site_id | BC8 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CX9 E 1399 |
| Chain | Residue |
| E | TRP99 |
| E | TRP218 |
| site_id | BC9 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CX9 F 1399 |
| Chain | Residue |
| F | TRP99 |
| F | TRP218 |
Functional Information from PROSITE/UniProt
| site_id | PS01095 |
| Number of Residues | 9 |
| Details | GH18_1 Glycosyl hydrolases family 18 (GH18) active site signature. FDGLDFDwE |
| Chain | Residue | Details |
| A | PHE132-GLU140 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | ACT_SITE: Proton donor => ECO:0000255|PROSITE-ProRule:PRU01258 |
| Chain | Residue | Details |
| A | GLU140 | |
| B | GLU140 | |
| C | GLU140 | |
| D | GLU140 | |
| E | GLU140 | |
| F | GLU140 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 30 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01258 |
| Chain | Residue | Details |
| C | TYR141 | |
| C | MET210 | |
| C | TRP360 | |
| D | GLU70 | |
| D | GLY97 | |
| D | TYR141 | |
| D | MET210 | |
| D | TRP360 | |
| E | GLU70 | |
| E | GLY97 | |
| E | TYR141 | |
| E | MET210 | |
| E | TRP360 | |
| F | GLU70 | |
| F | GLY97 | |
| F | TYR141 | |
| F | MET210 | |
| F | TRP360 | |
| A | GLU70 | |
| A | GLY97 | |
| A | TYR141 | |
| A | MET210 | |
| A | TRP360 | |
| B | GLU70 | |
| B | GLY97 | |
| B | TYR141 | |
| B | MET210 | |
| B | TRP360 | |
| C | GLU70 | |
| C | GLY97 |
