2X8B
Crystal structure of human acetylcholinesterase inhibited by aged tabun and complexed with fasciculin-II
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001507 | biological_process | acetylcholine catabolic process in synaptic cleft |
| A | 0001540 | molecular_function | amyloid-beta binding |
| A | 0001919 | biological_process | regulation of receptor recycling |
| A | 0002076 | biological_process | osteoblast development |
| A | 0003990 | molecular_function | acetylcholinesterase activity |
| A | 0004104 | molecular_function | cholinesterase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005518 | molecular_function | collagen binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005604 | cellular_component | basement membrane |
| A | 0005615 | cellular_component | extracellular space |
| A | 0005634 | cellular_component | nucleus |
| A | 0005794 | cellular_component | Golgi apparatus |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006581 | biological_process | acetylcholine catabolic process |
| A | 0007155 | biological_process | cell adhesion |
| A | 0007399 | biological_process | nervous system development |
| A | 0007416 | biological_process | synapse assembly |
| A | 0009986 | cellular_component | cell surface |
| A | 0016020 | cellular_component | membrane |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0017171 | molecular_function | serine hydrolase activity |
| A | 0031594 | cellular_component | neuromuscular junction |
| A | 0031623 | biological_process | receptor internalization |
| A | 0032223 | biological_process | negative regulation of synaptic transmission, cholinergic |
| A | 0042166 | molecular_function | acetylcholine binding |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0042803 | molecular_function | protein homodimerization activity |
| A | 0042982 | biological_process | amyloid precursor protein metabolic process |
| A | 0043083 | cellular_component | synaptic cleft |
| A | 0043236 | molecular_function | laminin binding |
| A | 0043621 | molecular_function | obsolete protein self-association |
| A | 0045202 | cellular_component | synapse |
| A | 0048471 | cellular_component | perinuclear region of cytoplasm |
| A | 0050714 | biological_process | positive regulation of protein secretion |
| A | 0052689 | molecular_function | carboxylic ester hydrolase activity |
| A | 0060041 | biological_process | retina development in camera-type eye |
| A | 0095500 | biological_process | acetylcholine receptor signaling pathway |
| A | 0098552 | cellular_component | side of membrane |
| A | 0120162 | biological_process | positive regulation of cold-induced thermogenesis |
| B | 0005576 | cellular_component | extracellular region |
| B | 0035821 | biological_process | modulation of process of another organism |
| B | 0090729 | molecular_function | toxin activity |
Functional Information from PROSITE/UniProt
| site_id | PS00122 |
| Number of Residues | 16 |
| Details | CARBOXYLESTERASE_B_1 Carboxylesterases type-B serine active site. FGGdptsVtLfGeSAG |
| Chain | Residue | Details |
| A | PHE190-GLY205 |
| site_id | PS00272 |
| Number of Residues | 19 |
| Details | SNAKE_TOXIN Snake toxins signature. GCg..CPpgddnlevk.CCtsP |
| Chain | Residue | Details |
| B | GLY38-PRO56 |
| site_id | PS00941 |
| Number of Residues | 11 |
| Details | CARBOXYLESTERASE_B_2 Carboxylesterases type-B signature 2. EDCLYLNVWtP |
| Chain | Residue | Details |
| A | GLU94-PRO104 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | SITE: Blocks the entrance of the active site gorge of hAChE => ECO:0000303|PubMed:23679855 |
| Chain | Residue | Details |
| B | MET33 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | ACT_SITE: Charge relay system |
| Chain | Residue | Details |
| A | GLU334 | |
| A | HIS447 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0007744|PDB:4EY5 |
| Chain | Residue | Details |
| A | TRP86 | |
| A | TYR133 | |
| A | TYR337 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0007744|PDB:4BDT |
| Chain | Residue | Details |
| A | GLY122 | |
| A | SEN203 | |
| A | TRP439 | |
| A | HIS447 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0007744|PDB:4EY6 |
| Chain | Residue | Details |
| A | GLU202 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:23035744, ECO:0007744|PDB:4EY4, ECO:0007744|PDB:4EY5, ECO:0007744|PDB:4EY6, ECO:0007744|PDB:4EY7 |
| Chain | Residue | Details |
| A | ASN265 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:11053835, ECO:0000269|PubMed:20408548, ECO:0000269|PubMed:23035744, ECO:0000269|PubMed:23679855, ECO:0007744|PDB:1B41, ECO:0007744|PDB:1F8U, ECO:0007744|PDB:2X8B, ECO:0007744|PDB:4BDT, ECO:0007744|PDB:4EY4, ECO:0007744|PDB:4EY5, ECO:0007744|PDB:4EY6, ECO:0007744|PDB:4EY7, ECO:0007744|PDB:4EY8 |
| Chain | Residue | Details |
| A | ASN350 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:23035744, ECO:0007744|PDB:4EY8 |
| Chain | Residue | Details |
| A | ASN464 |
