2WTZ
MurE ligase of Mycobacterium Tuberculosis
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0008360 | biological_process | regulation of cell shape |
| A | 0008765 | molecular_function | UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate ligase activity |
| A | 0009058 | biological_process | biosynthetic process |
| A | 0009252 | biological_process | peptidoglycan biosynthetic process |
| A | 0016874 | molecular_function | ligase activity |
| A | 0016881 | molecular_function | acid-amino acid ligase activity |
| A | 0051301 | biological_process | cell division |
| A | 0071555 | biological_process | cell wall organization |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0008360 | biological_process | regulation of cell shape |
| B | 0008765 | molecular_function | UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate ligase activity |
| B | 0009058 | biological_process | biosynthetic process |
| B | 0009252 | biological_process | peptidoglycan biosynthetic process |
| B | 0016874 | molecular_function | ligase activity |
| B | 0016881 | molecular_function | acid-amino acid ligase activity |
| B | 0051301 | biological_process | cell division |
| B | 0071555 | biological_process | cell wall organization |
| C | 0000287 | molecular_function | magnesium ion binding |
| C | 0005524 | molecular_function | ATP binding |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0008360 | biological_process | regulation of cell shape |
| C | 0008765 | molecular_function | UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate ligase activity |
| C | 0009058 | biological_process | biosynthetic process |
| C | 0009252 | biological_process | peptidoglycan biosynthetic process |
| C | 0016874 | molecular_function | ligase activity |
| C | 0016881 | molecular_function | acid-amino acid ligase activity |
| C | 0051301 | biological_process | cell division |
| C | 0071555 | biological_process | cell wall organization |
| D | 0000287 | molecular_function | magnesium ion binding |
| D | 0005524 | molecular_function | ATP binding |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0005886 | cellular_component | plasma membrane |
| D | 0008360 | biological_process | regulation of cell shape |
| D | 0008765 | molecular_function | UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate ligase activity |
| D | 0009058 | biological_process | biosynthetic process |
| D | 0009252 | biological_process | peptidoglycan biosynthetic process |
| D | 0016874 | molecular_function | ligase activity |
| D | 0016881 | molecular_function | acid-amino acid ligase activity |
| D | 0051301 | biological_process | cell division |
| D | 0071555 | biological_process | cell wall organization |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE UAG A 1498 |
| Chain | Residue |
| A | LEU67 |
| A | THR86 |
| A | GLY88 |
| A | HIS91 |
| A | LEU194 |
| A | THR195 |
| A | THR196 |
| A | GLU198 |
| A | SER222 |
| A | HIS224 |
| A | LEU228 |
| A | ARG68 |
| A | ARG230 |
| A | HIS248 |
| A | MG1499 |
| A | ALA69 |
| A | GLN70 |
| A | PHE78 |
| A | LEU81 |
| A | GLY83 |
| A | SER84 |
| A | THR85 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MG A 1499 |
| Chain | Residue |
| A | ASP247 |
| A | HIS248 |
| A | UAG1498 |
| site_id | AC3 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE UAG B 1498 |
| Chain | Residue |
| B | LEU67 |
| B | ARG68 |
| B | ALA69 |
| B | GLN70 |
| B | PHE78 |
| B | LEU81 |
| B | GLY83 |
| B | SER84 |
| B | THR85 |
| B | THR86 |
| B | GLY88 |
| B | HIS91 |
| B | ARG128 |
| B | LEU194 |
| B | THR195 |
| B | THR196 |
| B | GLU198 |
| B | SER222 |
| B | ARG230 |
| B | HIS248 |
| B | MG1499 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MG B 1499 |
| Chain | Residue |
| B | ASP247 |
| B | HIS248 |
| B | UAG1498 |
| site_id | AC5 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE UAG C 1498 |
| Chain | Residue |
| C | LEU67 |
| C | ARG68 |
| C | ALA69 |
| C | GLN70 |
| C | LEU81 |
| C | GLY83 |
| C | SER84 |
| C | THR85 |
| C | THR86 |
| C | GLY88 |
| C | HIS91 |
| C | ARG128 |
| C | LEU194 |
| C | THR195 |
| C | THR196 |
| C | GLU198 |
| C | SER222 |
| C | ARG230 |
| C | HIS248 |
| C | MG1499 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG C 1499 |
| Chain | Residue |
| C | ASP247 |
| C | HIS248 |
| C | KCX262 |
| C | UAG1498 |
| site_id | AC7 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE UAG D 1498 |
| Chain | Residue |
| D | LEU67 |
| D | ARG68 |
| D | ALA69 |
| D | GLN70 |
| D | PHE78 |
| D | GLY83 |
| D | SER84 |
| D | THR85 |
| D | THR86 |
| D | GLY88 |
| D | HIS91 |
| D | ARG128 |
| D | LEU194 |
| D | THR195 |
| D | THR196 |
| D | GLU198 |
| D | SER222 |
| D | HIS224 |
| D | LEU228 |
| D | ARG230 |
| D | HIS248 |
| D | MG1499 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MG D 1499 |
| Chain | Residue |
| D | ASP247 |
| D | HIS248 |
| D | UAG1498 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 36 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00208 |
| Chain | Residue | Details |
| A | LEU67 | |
| B | LEU67 | |
| B | GLY153 | |
| B | THR195 | |
| B | SER222 | |
| B | ARG230 | |
| B | ARG424 | |
| B | ASP448 | |
| B | GLY502 | |
| B | GLU506 | |
| C | LEU67 | |
| A | GLY153 | |
| C | GLY153 | |
| C | THR195 | |
| C | SER222 | |
| C | ARG230 | |
| C | ARG424 | |
| C | ASP448 | |
| C | GLY502 | |
| C | GLU506 | |
| D | LEU67 | |
| D | GLY153 | |
| A | THR195 | |
| D | THR195 | |
| D | SER222 | |
| D | ARG230 | |
| D | ARG424 | |
| D | ASP448 | |
| D | GLY502 | |
| D | GLU506 | |
| A | SER222 | |
| A | ARG230 | |
| A | ARG424 | |
| A | ASP448 | |
| A | GLY502 | |
| A | GLU506 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | MOD_RES: N6-carboxylysine => ECO:0000255|HAMAP-Rule:MF_00208 |
| Chain | Residue | Details |
| A | KCX262 | |
| B | KCX262 | |
| C | KCX262 | |
| D | KCX262 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1p3d |
| Chain | Residue | Details |
| A | LYS157 |
| site_id | CSA2 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1p3d |
| Chain | Residue | Details |
| B | LYS157 |
| site_id | CSA3 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1p3d |
| Chain | Residue | Details |
| C | LYS157 |
| site_id | CSA4 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1p3d |
| Chain | Residue | Details |
| D | LYS157 |
| site_id | CSA5 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1p3d |
| Chain | Residue | Details |
| A | THR152 |
| site_id | CSA6 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1p3d |
| Chain | Residue | Details |
| B | THR152 |
| site_id | CSA7 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1p3d |
| Chain | Residue | Details |
| C | THR152 |
| site_id | CSA8 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1p3d |
| Chain | Residue | Details |
| D | THR152 |
