2WRM

Identification of Novel Allosteric Inhibitors of Hepatitis C Virus NS5B Polymerase Thumb Domain (Site II) by Structure-Based Design

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003723	molecular_function	RNA binding
A	0003968	molecular_function	RNA-dependent RNA polymerase activity
A	0039694	biological_process	viral RNA genome replication

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	BINDING SITE FOR RESIDUE QQ3 A 1532

Chain	Residue
A	ARG422
A	HOH2625
A	MET423
A	TYR477
A	LEU497
A	ARG498
A	ARG501
A	TRP528
A	HOH2587
A	HOH2624

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site_id	AC2
Number of Residues	10
Details	BINDING SITE FOR RESIDUE QQ3 A 1533

Chain	Residue
A	SER19
A	THR41
A	ARG43
A	SER44
A	ARG154
A	GLN436
A	GLU437
A	QQ31534
A	HOH2080
A	HOH2627

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site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE QQ3 A 1534

Chain	Residue
A	GLY152
A	ARG154
A	QQ31533
A	HOH2629

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	BINDING: BINDING => ECO:0000305|PubMed:10557268, ECO:0000305|PubMed:11884572

Chain	Residue	Details
A	ASP220
A	ASP318
A	ASP319

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site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: Phosphoserine; by host => ECO:0000250|UniProtKB:P26662

Chain	Residue	Details
A	SER29
A	SER42

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