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2VZ9

Crystal Structure of Mammalian Fatty Acid Synthase in complex with NADP

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0003824molecular_functioncatalytic activity
A0004312molecular_functionfatty acid synthase activity
A0004313molecular_function[acyl-carrier-protein] S-acetyltransferase activity
A0004314molecular_function[acyl-carrier-protein] S-malonyltransferase activity
A0004315molecular_function3-oxoacyl-[acyl-carrier-protein] synthase activity
A0004316molecular_function3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
A0005737cellular_componentcytoplasm
A0006629biological_processlipid metabolic process
A0006631biological_processfatty acid metabolic process
A0006633biological_processfatty acid biosynthetic process
A0008152biological_processmetabolic process
A0009058biological_processbiosynthetic process
A0016297molecular_functionfatty acyl-[ACP] hydrolase activity
A0016419molecular_functionS-malonyltransferase activity
A0016491molecular_functionoxidoreductase activity
A0016740molecular_functiontransferase activity
A0016746molecular_functionacyltransferase activity
A0016787molecular_functionhydrolase activity
A0016829molecular_functionlyase activity
A0019171molecular_function(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
A0031177molecular_functionphosphopantetheine binding
A0036094molecular_functionsmall molecule binding
A0047117molecular_functionobsolete enoyl-[acyl-carrier-protein] reductase (NADPH, A-specific) activity
B0000166molecular_functionnucleotide binding
B0003824molecular_functioncatalytic activity
B0004312molecular_functionfatty acid synthase activity
B0004313molecular_function[acyl-carrier-protein] S-acetyltransferase activity
B0004314molecular_function[acyl-carrier-protein] S-malonyltransferase activity
B0004315molecular_function3-oxoacyl-[acyl-carrier-protein] synthase activity
B0004316molecular_function3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
B0005737cellular_componentcytoplasm
B0006629biological_processlipid metabolic process
B0006631biological_processfatty acid metabolic process
B0006633biological_processfatty acid biosynthetic process
B0008152biological_processmetabolic process
B0009058biological_processbiosynthetic process
B0016297molecular_functionfatty acyl-[ACP] hydrolase activity
B0016419molecular_functionS-malonyltransferase activity
B0016491molecular_functionoxidoreductase activity
B0016740molecular_functiontransferase activity
B0016746molecular_functionacyltransferase activity
B0016787molecular_functionhydrolase activity
B0016829molecular_functionlyase activity
B0019171molecular_function(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
B0031177molecular_functionphosphopantetheine binding
B0036094molecular_functionsmall molecule binding
B0047117molecular_functionobsolete enoyl-[acyl-carrier-protein] reductase (NADPH, A-specific) activity
Functional Information from PDB Data
site_idAC1
Number of Residues19
DetailsBINDING SITE FOR RESIDUE NAP A3001
ChainResidue
APHE1573
ALYS1704
ASER1723
AARG1724
AILE1769
AILE1794
ALEU1796
AMET1843
AALA1844
AGLY1846
AHIS1848
ATHR1654
ASER1675
ASER1677
AGLY1678
AGLY1679
AVAL1680
AVAL1699
AGLY1700

site_idAC2
Number of Residues22
DetailsBINDING SITE FOR RESIDUE NAP A3002
ChainResidue
AGLY1891
AGLY1894
APHE1896
ATHR1915
ASER1916
AARG1917
ASER1918
AARG1921
AASN1945
ALEU1971
AALA1972
AMET1973
ALYS1995
APHE2019
ASER2020
ASER2021
ATYR2034
AGLY2061
AILE2063
AGLY2067
AVAL2068
AVAL2069

site_idAC3
Number of Residues19
DetailsBINDING SITE FOR RESIDUE NAP B3001
ChainResidue
BPHE1573
BTHR1654
BSER1675
BSER1677
BGLY1678
BGLY1679
BVAL1680
BVAL1699
BGLY1700
BLYS1704
BSER1723
BARG1724
BILE1769
BLYS1771
BILE1794
BLEU1796
BALA1844
BGLY1846
BHIS1848

site_idAC4
Number of Residues20
DetailsBINDING SITE FOR RESIDUE NAP B3002
ChainResidue
BGLY1894
BPHE1896
BTHR1915
BSER1916
BARG1917
BSER1918
BASN1945
BLEU1971
BALA1972
BMET1973
BLYS1995
BPHE2019
BSER2020
BSER2021
BTYR2034
BGLY2061
BILE2063
BGLY2067
BVAL2068
BVAL2069

Functional Information from PROSITE/UniProt
site_idPS00606
Number of Residues17
DetailsKS3_1 Ketosynthase family 3 (KS3) active site signature. GPSitIDtACSSSllAL
ChainResidueDetails
AGLY152-LEU168

site_idPS00012
Number of Residues16
DetailsPHOSPHOPANTETHEINE Phosphopantetheine attachment site. DLGLDSLMGVEVRQIL
ChainResidueDetails
AASP2152-LEU2167

218853

PDB entries from 2024-04-24

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