2VOU

Structure of 2,6-dihydroxypyridine-3-hydroxylase from Arthrobacter nicotinovorans

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0016491	molecular_function	oxidoreductase activity
A	0018663	molecular_function	2,6-dihydroxypyridine 3-monooxygenase activity
A	0019608	biological_process	nicotine catabolic process
A	0042803	molecular_function	protein homodimerization activity
A	0050660	molecular_function	flavin adenine dinucleotide binding
A	0071949	molecular_function	FAD binding
B	0000166	molecular_function	nucleotide binding
B	0016491	molecular_function	oxidoreductase activity
B	0018663	molecular_function	2,6-dihydroxypyridine 3-monooxygenase activity
B	0019608	biological_process	nicotine catabolic process
B	0042803	molecular_function	protein homodimerization activity
B	0050660	molecular_function	flavin adenine dinucleotide binding
B	0071949	molecular_function	FAD binding
C	0000166	molecular_function	nucleotide binding
C	0016491	molecular_function	oxidoreductase activity
C	0018663	molecular_function	2,6-dihydroxypyridine 3-monooxygenase activity
C	0019608	biological_process	nicotine catabolic process
C	0042803	molecular_function	protein homodimerization activity
C	0050660	molecular_function	flavin adenine dinucleotide binding
C	0071949	molecular_function	FAD binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	35
Details	BINDING SITE FOR RESIDUE FAD A1395

Chain	Residue
A	GLY12
A	VAL49
A	LYS118
A	CYS119
A	LEU120
A	ALA148
A	ASP149
A	GLY150
A	VAL154
A	ARG173
A	GLN222
A	SER14
A	GLY305
A	ASP306
A	ALA316
A	ALA317
A	GLY318
A	GLY319
A	ALA320
A	GOL1396
A	ACT1397
A	HOH2065
A	ILE15
A	HOH2067
A	HOH2187
A	HOH2188
A	HOH2189
A	HOH2190
A	HOH2191
A	SER16
A	TYR34
A	GLU35
A	ARG36
A	LEU41
A	ILE48

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL A1396

Chain	Residue
A	TYR206
A	GLN222
A	TYR224
A	PRO313
A	FAD1395
A	HOH2192

---

site_id	AC3
Number of Residues	9
Details	BINDING SITE FOR RESIDUE ACT A1397

Chain	Residue
A	PRO311
A	ARG312
A	PRO313
A	ALA316
A	ALA317
A	GLY318
A	TYR357
A	FAD1395
A	HOH2159

---

site_id	AC4
Number of Residues	31
Details	BINDING SITE FOR RESIDUE FAD B1389

Chain	Residue
B	VAL11
B	GLY12
B	SER14
B	ILE15
B	SER16
B	TYR34
B	GLU35
B	ARG36
B	LEU41
B	ILE48
B	VAL49
B	LYS118
B	CYS119
B	LEU120
B	ALA148
B	ASP149
B	GLY150
B	VAL154
B	GLN222
B	ASP306
B	ALA316
B	ALA317
B	GLY318
B	GLY319
B	ALA320
B	GOL1390
B	ACT1391
B	HOH2034
B	HOH2125
B	HOH2126
B	HOH2127

---

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL B1390

Chain	Residue
B	TYR206
B	GLN222
B	TYR224
B	PRO313
B	FAD1389
B	HOH2110

---

site_id	AC6
Number of Residues	8
Details	BINDING SITE FOR RESIDUE ACT B1391

Chain	Residue
B	ARG312
B	PRO313
B	ALA316
B	ALA317
B	GLY318
B	TYR357
B	FAD1389
B	HOH2109

---

site_id	AC7
Number of Residues	31
Details	BINDING SITE FOR RESIDUE FAD C1389

Chain	Residue
C	SER16
C	TYR34
C	GLU35
C	ARG36
C	LEU41
C	ILE48
C	VAL49
C	LYS118
C	CYS119
C	LEU120
C	ASP149
C	GLY150
C	VAL154
C	GLN222
C	GLY305
C	ASP306
C	ALA316
C	ALA317
C	GLY318
C	GLY319
C	ALA320
C	GOL1390
C	ACT1391
C	HOH2022
C	HOH2066
C	HOH2067
C	HOH2068
C	VAL11
C	GLY12
C	SER14
C	ILE15

---

site_id	AC8
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL C1390

Chain	Residue
C	TYR206
C	GLN222
C	TYR224
C	PRO313
C	ALA316
C	FAD1389
C	HOH2033

---

site_id	AC9
Number of Residues	9
Details	BINDING SITE FOR RESIDUE ACT C1391

Chain	Residue
C	PRO311
C	ARG312
C	PRO313
C	ALA316
C	ALA317
C	GLY318
C	TYR357
C	FAD1389
C	HOH2056

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	18
Details	BINDING: BINDING => ECO:0000269|PubMed:18440023

Chain	Residue	Details
A	SER14
B	LEU120
B	ASP306
B	ALA316
C	SER14
C	GLU35
C	VAL49
C	LEU120
C	ASP306
C	ALA316
A	GLU35
A	VAL49
A	LEU120
A	ASP306
A	ALA316
B	SER14
B	GLU35
B	VAL49

---