2V9M
L-RHAMNULOSE-1-PHOSPHATE ALDOLASE FROM ESCHERICHIA COLI (MUTANT A87M- T109F-E192A)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0005996 | biological_process | monosaccharide metabolic process |
| A | 0008994 | molecular_function | rhamnulose-1-phosphate aldolase activity |
| A | 0016829 | molecular_function | lyase activity |
| A | 0016830 | molecular_function | carbon-carbon lyase activity |
| A | 0016832 | molecular_function | aldehyde-lyase activity |
| A | 0019299 | biological_process | rhamnose metabolic process |
| A | 0019301 | biological_process | rhamnose catabolic process |
| A | 0019323 | biological_process | pentose catabolic process |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0005996 | biological_process | monosaccharide metabolic process |
| B | 0008994 | molecular_function | rhamnulose-1-phosphate aldolase activity |
| B | 0016829 | molecular_function | lyase activity |
| B | 0016830 | molecular_function | carbon-carbon lyase activity |
| B | 0016832 | molecular_function | aldehyde-lyase activity |
| B | 0019299 | biological_process | rhamnose metabolic process |
| B | 0019301 | biological_process | rhamnose catabolic process |
| B | 0019323 | biological_process | pentose catabolic process |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN A1275 |
| Chain | Residue |
| A | HIS141 |
| A | HIS143 |
| A | HIS212 |
| A | HOH2246 |
| A | HOH2408 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A1277 |
| Chain | Residue |
| A | ASP157 |
| A | CIT1278 |
| B | HIS46 |
| B | HIS50 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A1276 |
| Chain | Residue |
| A | GLU200 |
| A | HIS204 |
| A | CIT1278 |
| A | HOH2324 |
| A | HOH2409 |
| A | HOH2411 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN B1275 |
| Chain | Residue |
| B | HIS141 |
| B | HIS143 |
| B | HIS212 |
| B | HOH2387 |
| B | HOH2388 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B1276 |
| Chain | Residue |
| A | HIS46 |
| A | ASP47 |
| B | GLU200 |
| B | HIS204 |
| site_id | AC6 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE CIT A1278 |
| Chain | Residue |
| A | ASP157 |
| A | THR158 |
| A | ALA159 |
| A | HIS204 |
| A | SER270 |
| A | CA1276 |
| A | ZN1277 |
| A | HOH2324 |
| A | HOH2409 |
| A | HOH2410 |
| A | HOH2411 |
| A | HOH2412 |
| B | HIS46 |
| B | ASP47 |
| B | HIS50 |
| B | HOH2108 |
| site_id | AC7 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE EDO B1277 |
| Chain | Residue |
| B | LEU150 |
| B | THR151 |
| B | LEU154 |
| B | GLU155 |
| B | PHE161 |
| B | PRO210 |
| B | GLN249 |
| B | HOH2389 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO A1279 |
| Chain | Residue |
| A | PHE78 |
| A | ASP222 |
| A | HOH2176 |
| A | HOH2220 |
| A | HOH2339 |
| A | HOH2413 |
| site_id | AC9 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE EDO B1278 |
| Chain | Residue |
| B | ARG128 |
| B | ASP178 |
| B | GLN202 |
| B | LYS203 |
| B | HIS204 |
| B | SER205 |
| B | HOH2235 |
| B | HOH2274 |
| site_id | BC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE EDO B1279 |
| Chain | Residue |
| B | GLY76 |
| B | PHE78 |
| B | ASP222 |
| B | GLU223 |
| B | HOH2209 |
| B | HOH2308 |
| B | HOH2391 |
| B | HOH2392 |
| site_id | BC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO B1280 |
| Chain | Residue |
| B | TYR242 |
| B | SER243 |
| B | MET244 |
| B | GLY245 |
| B | HOH2393 |
| B | HOH2394 |
| site_id | BC3 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE EDO A1280 |
| Chain | Residue |
| A | LYS23 |
| A | TRP25 |
| A | ASN146 |
| A | GLU232 |
| A | GLN236 |
| A | HOH2055 |
| A | HOH2270 |
| A | HOH2350 |
| A | HOH2414 |
| A | HOH2415 |
| site_id | BC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO A1281 |
| Chain | Residue |
| A | SER97 |
| A | HOH2081 |
| A | HOH2417 |
| B | VAL160 |
| B | HOH2249 |
| B | HOH2251 |
| site_id | BC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO A1282 |
| Chain | Residue |
| A | TYR242 |
| A | SER243 |
| A | MET244 |
| A | GLY245 |
| A | HOH2418 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: ACT_SITE => ECO:0000269|PubMed:11976494, ECO:0000269|PubMed:12962479 |
| Chain | Residue | Details |
| A | GLU117 | |
| B | GLU117 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:11976494, ECO:0000269|PubMed:12962479 |
| Chain | Residue | Details |
| A | HIS141 | |
| A | HIS143 | |
| A | HIS212 | |
| B | HIS141 | |
| B | HIS143 | |
| B | HIS212 |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 5 |
| Details | M-CSA 645 |
| Chain | Residue | Details |
| A | GLU117 | proton acceptor, proton donor |
| A | HIS141 | metal ligand |
| A | HIS143 | metal ligand |
| A | GLU171 | proton donor |
| A | HIS212 | metal ligand |
| site_id | MCSA2 |
| Number of Residues | 5 |
| Details | M-CSA 645 |
| Chain | Residue | Details |
| B | GLU117 | proton acceptor, proton donor |
| B | HIS141 | metal ligand |
| B | HIS143 | metal ligand |
| B | GLU171 | proton donor |
| B | HIS212 | metal ligand |
