2V74
Crystal structure of coactivator-associated arginine methyltransferase 1 (CARM1), in complex with S-adenosyl-homocysteine
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| B | 0016274 | molecular_function | protein-arginine N-methyltransferase activity |
| B | 0018216 | biological_process | peptidyl-arginine methylation |
| D | 0016274 | molecular_function | protein-arginine N-methyltransferase activity |
| D | 0018216 | biological_process | peptidyl-arginine methylation |
| F | 0016274 | molecular_function | protein-arginine N-methyltransferase activity |
| F | 0018216 | biological_process | peptidyl-arginine methylation |
| H | 0016274 | molecular_function | protein-arginine N-methyltransferase activity |
| H | 0018216 | biological_process | peptidyl-arginine methylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE SAH B1478 |
| Chain | Residue |
| B | TYR150 |
| B | LEU199 |
| B | GLU215 |
| B | ALA216 |
| B | GLY241 |
| B | LYS242 |
| B | VAL243 |
| B | GLU244 |
| B | MET269 |
| B | SER272 |
| B | HOH2005 |
| B | PHE151 |
| B | HOH2006 |
| B | HOH2054 |
| B | TYR154 |
| B | GLN160 |
| B | MET163 |
| B | ARG169 |
| B | GLY193 |
| B | CYS194 |
| B | ILE198 |
| site_id | AC2 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE SAH D1480 |
| Chain | Residue |
| D | TYR150 |
| D | PHE151 |
| D | TYR154 |
| D | GLN160 |
| D | MET163 |
| D | ARG169 |
| D | GLY193 |
| D | CYS194 |
| D | ILE198 |
| D | LEU199 |
| D | GLU215 |
| D | ALA216 |
| D | GLY241 |
| D | LYS242 |
| D | VAL243 |
| D | GLU244 |
| D | GLU258 |
| D | MET269 |
| D | SER272 |
| D | HOH2004 |
| D | HOH2067 |
| site_id | AC3 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE SAH F1479 |
| Chain | Residue |
| F | TYR150 |
| F | PHE151 |
| F | TYR154 |
| F | GLN160 |
| F | MET163 |
| F | ARG169 |
| F | GLY193 |
| F | CYS194 |
| F | GLY195 |
| F | ILE198 |
| F | LEU199 |
| F | GLU215 |
| F | ALA216 |
| F | SER217 |
| F | GLY241 |
| F | LYS242 |
| F | VAL243 |
| F | GLU244 |
| F | MET269 |
| F | SER272 |
| site_id | AC4 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE SAH H1478 |
| Chain | Residue |
| H | PHE151 |
| H | TYR154 |
| H | GLN160 |
| H | MET163 |
| H | ARG169 |
| H | GLY193 |
| H | CYS194 |
| H | ILE198 |
| H | LEU199 |
| H | GLU215 |
| H | ALA216 |
| H | GLY241 |
| H | LYS242 |
| H | VAL243 |
| H | GLU244 |
| H | GLU258 |
| H | MET269 |
| H | SER272 |
| H | HOH2004 |
| H | HOH2008 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 24 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:17882261 |
| Chain | Residue | Details |
| B | GLN160 | |
| D | GLU215 | |
| D | GLU244 | |
| D | SER272 | |
| F | GLN160 | |
| F | ARG169 | |
| F | GLY193 | |
| F | GLU215 | |
| F | GLU244 | |
| F | SER272 | |
| H | GLN160 | |
| B | ARG169 | |
| H | ARG169 | |
| H | GLY193 | |
| H | GLU215 | |
| H | GLU244 | |
| H | SER272 | |
| B | GLY193 | |
| B | GLU215 | |
| B | GLU244 | |
| B | SER272 | |
| D | GLN160 | |
| D | ARG169 | |
| D | GLY193 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:19843527 |
| Chain | Residue | Details |
| B | SER217 | |
| D | SER217 | |
| F | SER217 | |
| H | SER217 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:Q86X55 |
| Chain | Residue | Details |
| B | LYS228 | |
| D | LYS228 | |
| F | LYS228 | |
| H | LYS228 |
