2UV6

Crystal Structure of a CBS domain pair from the regulatory gamma1 subunit of human AMPK in complex with AMP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0032559	molecular_function	adenyl ribonucleotide binding
A	0071900	biological_process	regulation of protein serine/threonine kinase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	17
Details	BINDING SITE FOR RESIDUE AMP A1324

Chain	Residue
A	THR200
A	ASP317
A	HOH2049
A	HOH2066
A	HOH2195
A	HOH2196
A	HOH2197
A	HOH2198
A	HOH2199
A	ASN203
A	ILE204
A	ALA205
A	SER226
A	ALA227
A	ILE312
A	SER314
A	SER316

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	5
Details	BINDING: BINDING => ECO:0000269|PubMed:17452784, ECO:0000269|PubMed:24352254, ECO:0000269|PubMed:25412657, ECO:0007744|PDB:4CFF

Chain	Residue	Details
A	THR200
A	ALA205
A	SER226
A	HIS298
A	SER314

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site_id	SWS_FT_FI2
Number of Residues	3
Details	BINDING: BINDING => ECO:0000250|UniProtKB:P80385

Chain	Residue	Details
A	SER242
A	ARG269
A	LEU277

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site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: Phosphoserine; by ULK1 => ECO:0000250|UniProtKB:P80385

Chain	Residue	Details
A	SER261
A	SER270

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site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphothreonine; by ULK1 => ECO:0000250|UniProtKB:P80385

Chain	Residue	Details
A	THR263

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