2RBU

Cytochrome C Peroxidase in complex with cyclopentane-carboximidamide

Functional Information from GO Data

Chain	GOid	namespace	contents
X	0004601	molecular_function	peroxidase activity
X	0006979	biological_process	response to oxidative stress
X	0020037	molecular_function	heme binding
X	0034599	biological_process	cellular response to oxidative stress

Functional Information from PDB Data

site_id	AC1
Number of Residues	23
Details	BINDING SITE FOR RESIDUE HEM X 400

Chain	Residue
X	PRO44
X	HIS175
X	LEU177
X	GLY178
X	LYS179
X	THR180
X	HIS181
X	ASN184
X	SER185
X	LEU232
X	THR234
X	ARG48
X	HOH418
X	HOH424
X	HOH459
X	HOH1047
X	TRP51
X	PRO145
X	ASP146
X	ALA147
X	LEU171
X	MET172
X	ALA174

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site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE 273 X 4001

Chain	Residue
X	HIS175
X	THR180
X	MET230
X	MET231
X	ASP235

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Functional Information from PROSITE/UniProt

site_id	PS00435
Number of Residues	11
Details	PEROXIDASE_1 Peroxidases proximal heme-ligand signature. EVVALMGAHAL

Chain	Residue	Details
X	GLU167-LEU177

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site_id	PS00436
Number of Residues	12
Details	PEROXIDASE_2 Peroxidases active site signature. GPvlVRLaWHIS

Chain	Residue	Details
X	GLY43-SER54

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton acceptor

Chain	Residue	Details
X	HIS52

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site_id	SWS_FT_FI2
Number of Residues	1
Details	ACT_SITE: Tryptophan radical intermediate => ECO:0000269|PubMed:2851317

Chain	Residue	Details
X	GLY191

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site_id	SWS_FT_FI3
Number of Residues	1
Details	BINDING: axial binding residue => ECO:0000269|PubMed:10722697, ECO:0000269|PubMed:11170452, ECO:0000269|PubMed:2169873, ECO:0000269|PubMed:6092361, ECO:0000269|PubMed:8384877, ECO:0000269|PubMed:8673607

Chain	Residue	Details
X	HIS175

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site_id	SWS_FT_FI4
Number of Residues	1
Details	SITE: Transition state stabilizer

Chain	Residue	Details
X	ARG48

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site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:18407956

Chain	Residue	Details
X	TYR153

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Catalytic Information from CSA

site_id	MCSA1
Number of Residues	3
Details	M-CSA 709

Chain	Residue	Details
X	ARG48	electrostatic stabiliser
X	HIS52	electrostatic stabiliser, proton acceptor, proton donor
X	GLY191	single electron acceptor, single electron donor

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