2R17

Functional architecture of the retromer cargo-recognition complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005768	cellular_component	endosome
A	0005769	cellular_component	early endosome
A	0005770	cellular_component	late endosome
A	0005829	cellular_component	cytosol
A	0006886	biological_process	intracellular protein transport
A	0010008	cellular_component	endosome membrane
A	0010506	biological_process	regulation of autophagy
A	0015031	biological_process	protein transport
A	0016020	cellular_component	membrane
A	0030904	cellular_component	retromer complex
A	0030906	cellular_component	retromer, cargo-selective complex
A	0032456	biological_process	endocytic recycling
A	0042147	biological_process	retrograde transport, endosome to Golgi
A	0043231	cellular_component	intracellular membrane-bounded organelle
A	0046872	molecular_function	metal ion binding
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005768	cellular_component	endosome
B	0005769	cellular_component	early endosome
B	0005770	cellular_component	late endosome
B	0005829	cellular_component	cytosol
B	0006886	biological_process	intracellular protein transport
B	0010008	cellular_component	endosome membrane
B	0010506	biological_process	regulation of autophagy
B	0015031	biological_process	protein transport
B	0016020	cellular_component	membrane
B	0030904	cellular_component	retromer complex
B	0030906	cellular_component	retromer, cargo-selective complex
B	0032456	biological_process	endocytic recycling
B	0042147	biological_process	retrograde transport, endosome to Golgi
B	0043231	cellular_component	intracellular membrane-bounded organelle
B	0046872	molecular_function	metal ion binding
C	0015031	biological_process	protein transport
C	0030906	cellular_component	retromer, cargo-selective complex
C	0042147	biological_process	retrograde transport, endosome to Golgi
D	0015031	biological_process	protein transport
D	0030906	cellular_component	retromer, cargo-selective complex
D	0042147	biological_process	retrograde transport, endosome to Golgi

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL D 1

Chain	Residue
D	ALA577
D	GLU578
D	LEU579

---

site_id	AC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE GOL D 2

Chain	Residue
C	HOH787
D	ASN744

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	14
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
A	ASP8
B	ASN39
B	ASP62
B	HIS86
B	HIS115
B	HIS117
A	HIS10
A	ASN39
A	ASP62
A	HIS86
A	HIS115
A	HIS117
B	ASP8
B	HIS10

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861

Chain	Residue	Details
A	LYS50
B	LYS50

---