2QYI
Crystal structure of a binary complex between an engineered trypsin inhibitor and Bovine trypsin
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004175 | molecular_function | endopeptidase activity |
| A | 0004252 | molecular_function | serine-type endopeptidase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005615 | cellular_component | extracellular space |
| A | 0006508 | biological_process | proteolysis |
| A | 0007586 | biological_process | digestion |
| A | 0008236 | molecular_function | serine-type peptidase activity |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0097180 | cellular_component | serine protease inhibitor complex |
| A | 0097655 | molecular_function | serpin family protein binding |
| B | 0004866 | molecular_function | endopeptidase inhibitor activity |
| B | 0004867 | molecular_function | serine-type endopeptidase inhibitor activity |
| C | 0004175 | molecular_function | endopeptidase activity |
| C | 0004252 | molecular_function | serine-type endopeptidase activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005576 | cellular_component | extracellular region |
| C | 0005615 | cellular_component | extracellular space |
| C | 0006508 | biological_process | proteolysis |
| C | 0007586 | biological_process | digestion |
| C | 0008236 | molecular_function | serine-type peptidase activity |
| C | 0046872 | molecular_function | metal ion binding |
| C | 0097180 | cellular_component | serine protease inhibitor complex |
| C | 0097655 | molecular_function | serpin family protein binding |
| D | 0004866 | molecular_function | endopeptidase inhibitor activity |
| D | 0004867 | molecular_function | serine-type endopeptidase inhibitor activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CA A 991 |
| Chain | Residue |
| A | GLU70 |
| A | ASN72 |
| A | GLU80 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE NI B 992 |
| Chain | Residue |
| B | HIS626 |
| B | HIS727 |
| B | GLU772 |
| D | HIS830 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CA C 990 |
| Chain | Residue |
| C | GLU380 |
| C | GLU370 |
| C | ASN372 |
Functional Information from PROSITE/UniProt
| site_id | PS00134 |
| Number of Residues | 6 |
| Details | TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. VSAAHC |
| Chain | Residue | Details |
| A | VAL53-CYS58 |
| site_id | PS00135 |
| Number of Residues | 12 |
| Details | TRYPSIN_SER Serine proteases, trypsin family, serine active site. DScqGDSGGPVV |
| Chain | Residue | Details |
| A | ASP189-VAL200 |
| site_id | PS00283 |
| Number of Residues | 17 |
| Details | SOYBEAN_KUNITZ Soybean trypsin inhibitor (Kunitz) protease inhibitors family signature. LvDAEGNlVeNGgtYyL |
| Chain | Residue | Details |
| B | LEU607-LEU623 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | SITE: Reactive bond for chymotrypsin |
| Chain | Residue | Details |
| B | ARG668 | |
| D | ARG868 | |
| A | PRO198 | |
| C | LYS360 | |
| C | LEU405 | |
| C | PRO498 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 14 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | ILE73 | |
| A | GLN192 | |
| A | SER195 | |
| A | PRO198 | |
| C | ILE373 | |
| C | VAL375 | |
| C | GLY378 | |
| C | ILE383 | |
| C | GLN492 | |
| C | SER495 | |
| C | PRO498 | |
| A | VAL75 | |
| A | GLY78 | |
| A | ILE83 |
