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2QRI

Crystal structure of a single chain trimer composed of the MHC I heavy chain H-2Kb WT, beta-2microglobulin, and ovalbumin-derived peptide.

Functional Information from GO Data
ChainGOidnamespacecontents
A0001913biological_processT cell mediated cytotoxicity
A0001916biological_processpositive regulation of T cell mediated cytotoxicity
A0002237biological_processresponse to molecule of bacterial origin
A0002474biological_processantigen processing and presentation of peptide antigen via MHC class I
A0002481biological_processantigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
A0002502biological_processpeptide antigen assembly with MHC class I protein complex
A0002503biological_processpeptide antigen assembly with MHC class II protein complex
A0002726biological_processpositive regulation of T cell cytokine production
A0005198molecular_functionstructural molecule activity
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005765cellular_componentlysosomal membrane
A0005794cellular_componentGolgi apparatus
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0006826biological_processiron ion transport
A0006879biological_processintracellular iron ion homeostasis
A0006955biological_processimmune response
A0006968biological_processcellular defense response
A0007608biological_processsensory perception of smell
A0007611biological_processlearning or memory
A0009897cellular_componentexternal side of plasma membrane
A0010977biological_processnegative regulation of neuron projection development
A0019885biological_processantigen processing and presentation of endogenous peptide antigen via MHC class I
A0019886biological_processantigen processing and presentation of exogenous peptide antigen via MHC class II
A0023026molecular_functionMHC class II protein complex binding
A0030670cellular_componentphagocytic vesicle membrane
A0031902cellular_componentlate endosome membrane
A0033077biological_processT cell differentiation in thymus
A0034756biological_processregulation of iron ion transport
A0042026biological_processprotein refolding
A0042605molecular_functionpeptide antigen binding
A0042612cellular_componentMHC class I protein complex
A0042613cellular_componentMHC class II protein complex
A0042802molecular_functionidentical protein binding
A0042803molecular_functionprotein homodimerization activity
A0042824cellular_componentMHC class I peptide loading complex
A0045646biological_processregulation of erythrocyte differentiation
A0048260biological_processpositive regulation of receptor-mediated endocytosis
A0050680biological_processnegative regulation of epithelial cell proliferation
A0050768biological_processnegative regulation of neurogenesis
A0050778biological_processpositive regulation of immune response
A0050870biological_processpositive regulation of T cell activation
A0051289biological_processprotein homotetramerization
A0060586biological_processmulticellular organismal-level iron ion homeostasis
A0071281biological_processcellular response to iron ion
A0071283biological_processcellular response to iron(III) ion
A0071316biological_processcellular response to nicotine
A1990000biological_processamyloid fibril formation
A1990712cellular_componentHFE-transferrin receptor complex
A2000774biological_processpositive regulation of cellular senescence
A2000978biological_processnegative regulation of forebrain neuron differentiation
B0001913biological_processT cell mediated cytotoxicity
B0001916biological_processpositive regulation of T cell mediated cytotoxicity
B0002237biological_processresponse to molecule of bacterial origin
B0002474biological_processantigen processing and presentation of peptide antigen via MHC class I
B0002481biological_processantigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
B0002502biological_processpeptide antigen assembly with MHC class I protein complex
B0002503biological_processpeptide antigen assembly with MHC class II protein complex
B0002726biological_processpositive regulation of T cell cytokine production
B0005198molecular_functionstructural molecule activity
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005765cellular_componentlysosomal membrane
B0005794cellular_componentGolgi apparatus
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0006826biological_processiron ion transport
B0006879biological_processintracellular iron ion homeostasis
B0006955biological_processimmune response
B0006968biological_processcellular defense response
B0007608biological_processsensory perception of smell
B0007611biological_processlearning or memory
B0009897cellular_componentexternal side of plasma membrane
B0010977biological_processnegative regulation of neuron projection development
B0019885biological_processantigen processing and presentation of endogenous peptide antigen via MHC class I
B0019886biological_processantigen processing and presentation of exogenous peptide antigen via MHC class II
B0023026molecular_functionMHC class II protein complex binding
B0030670cellular_componentphagocytic vesicle membrane
B0031902cellular_componentlate endosome membrane
B0033077biological_processT cell differentiation in thymus
B0034756biological_processregulation of iron ion transport
B0042026biological_processprotein refolding
B0042605molecular_functionpeptide antigen binding
B0042612cellular_componentMHC class I protein complex
B0042613cellular_componentMHC class II protein complex
B0042802molecular_functionidentical protein binding
B0042803molecular_functionprotein homodimerization activity
B0042824cellular_componentMHC class I peptide loading complex
B0045646biological_processregulation of erythrocyte differentiation
B0048260biological_processpositive regulation of receptor-mediated endocytosis
B0050680biological_processnegative regulation of epithelial cell proliferation
B0050768biological_processnegative regulation of neurogenesis
B0050778biological_processpositive regulation of immune response
B0050870biological_processpositive regulation of T cell activation
B0051289biological_processprotein homotetramerization
B0060586biological_processmulticellular organismal-level iron ion homeostasis
B0071281biological_processcellular response to iron ion
B0071283biological_processcellular response to iron(III) ion
B0071316biological_processcellular response to nicotine
B1990000biological_processamyloid fibril formation
B1990712cellular_componentHFE-transferrin receptor complex
B2000774biological_processpositive regulation of cellular senescence
B2000978biological_processnegative regulation of forebrain neuron differentiation
Functional Information from PROSITE/UniProt
site_idPS00290
Number of Residues7
DetailsIG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACRVKH
ChainResidueDetails
ATYR78-HIS84
ATYR257-HIS263

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19349973, ECO:0000269|PubMed:7306483
ChainResidueDetails
AASN86
BASN86

site_idSWS_FT_FI2
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:7306483
ChainResidueDetails
AASN176
BASN176

220113

PDB entries from 2024-05-22

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