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2QFW

Crystal structure of Saccharomyces cerevesiae mitochondrial NADP(+)-dependent isocitrate dehydrogenase in complex with isocitrate

Functional Information from GO Data
ChainGOidnamespacecontents
A0000287molecular_functionmagnesium ion binding
A0004450molecular_functionisocitrate dehydrogenase (NADP+) activity
A0005515molecular_functionprotein binding
A0005739cellular_componentmitochondrion
A0006097biological_processglyoxylate cycle
A0006099biological_processtricarboxylic acid cycle
A0006102biological_processisocitrate metabolic process
A0006537biological_processglutamate biosynthetic process
A0006739biological_processNADP metabolic process
A0016491molecular_functionoxidoreductase activity
A0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
A0042645cellular_componentmitochondrial nucleoid
A0046872molecular_functionmetal ion binding
A0051287molecular_functionNAD binding
B0000287molecular_functionmagnesium ion binding
B0004450molecular_functionisocitrate dehydrogenase (NADP+) activity
B0005515molecular_functionprotein binding
B0005739cellular_componentmitochondrion
B0006097biological_processglyoxylate cycle
B0006099biological_processtricarboxylic acid cycle
B0006102biological_processisocitrate metabolic process
B0006537biological_processglutamate biosynthetic process
B0006739biological_processNADP metabolic process
B0016491molecular_functionoxidoreductase activity
B0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
B0042645cellular_componentmitochondrial nucleoid
B0046872molecular_functionmetal ion binding
B0051287molecular_functionNAD binding
C0000287molecular_functionmagnesium ion binding
C0004450molecular_functionisocitrate dehydrogenase (NADP+) activity
C0005515molecular_functionprotein binding
C0005739cellular_componentmitochondrion
C0006097biological_processglyoxylate cycle
C0006099biological_processtricarboxylic acid cycle
C0006102biological_processisocitrate metabolic process
C0006537biological_processglutamate biosynthetic process
C0006739biological_processNADP metabolic process
C0016491molecular_functionoxidoreductase activity
C0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
C0042645cellular_componentmitochondrial nucleoid
C0046872molecular_functionmetal ion binding
C0051287molecular_functionNAD binding
D0000287molecular_functionmagnesium ion binding
D0004450molecular_functionisocitrate dehydrogenase (NADP+) activity
D0005515molecular_functionprotein binding
D0005739cellular_componentmitochondrion
D0006097biological_processglyoxylate cycle
D0006099biological_processtricarboxylic acid cycle
D0006102biological_processisocitrate metabolic process
D0006537biological_processglutamate biosynthetic process
D0006739biological_processNADP metabolic process
D0016491molecular_functionoxidoreductase activity
D0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
D0042645cellular_componentmitochondrial nucleoid
D0046872molecular_functionmetal ion binding
D0051287molecular_functionNAD binding
E0000287molecular_functionmagnesium ion binding
E0004450molecular_functionisocitrate dehydrogenase (NADP+) activity
E0005515molecular_functionprotein binding
E0005739cellular_componentmitochondrion
E0006097biological_processglyoxylate cycle
E0006099biological_processtricarboxylic acid cycle
E0006102biological_processisocitrate metabolic process
E0006537biological_processglutamate biosynthetic process
E0006739biological_processNADP metabolic process
E0016491molecular_functionoxidoreductase activity
E0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
E0042645cellular_componentmitochondrial nucleoid
E0046872molecular_functionmetal ion binding
E0051287molecular_functionNAD binding
F0000287molecular_functionmagnesium ion binding
F0004450molecular_functionisocitrate dehydrogenase (NADP+) activity
F0005515molecular_functionprotein binding
F0005739cellular_componentmitochondrion
F0006097biological_processglyoxylate cycle
F0006099biological_processtricarboxylic acid cycle
F0006102biological_processisocitrate metabolic process
F0006537biological_processglutamate biosynthetic process
F0006739biological_processNADP metabolic process
F0016491molecular_functionoxidoreductase activity
F0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
F0042645cellular_componentmitochondrial nucleoid
F0046872molecular_functionmetal ion binding
F0051287molecular_functionNAD binding
Functional Information from PDB Data
site_idAC1
Number of Residues10
DetailsBINDING SITE FOR RESIDUE ICT A 2101
ChainResidue
ATHR78
BASP254
ASER95
AASN97
AARG101
AARG110
AARG133
ATYR140
AASP277
BLYS214

site_idAC2
Number of Residues11
DetailsBINDING SITE FOR RESIDUE ICT B 2102
ChainResidue
ALYS214
AASP254
BTHR78
BSER95
BASN97
BARG101
BARG110
BARG133
BTYR140
BASP277
BHOH2305

site_idAC3
Number of Residues12
DetailsBINDING SITE FOR RESIDUE ICT C 2103
ChainResidue
CTHR78
CSER95
CASN97
CARG101
CARG110
CARG133
CTYR140
CASP277
CHOH2131
DLYS214
DILE217
DASP254

site_idAC4
Number of Residues10
DetailsBINDING SITE FOR RESIDUE ICT D 2104
ChainResidue
CHOH2195
DSER95
DASN97
DARG101
DARG110
DARG133
DASP277
DHOH2135
DHOH2139
DHOH2254

site_idAC5
Number of Residues12
DetailsBINDING SITE FOR RESIDUE ICT E 2105
ChainResidue
ETHR78
ESER95
EASN97
EARG101
EARG110
EARG133
ETYR140
EASP277
EHOH2108
FLYS214
FASP254
FHOH2141

site_idAC6
Number of Residues10
DetailsBINDING SITE FOR RESIDUE ICT F 2106
ChainResidue
EILE217
EASP254
FTHR78
FSER95
FASN97
FARG101
FARG110
FARG133
FASP277
FHOH2126

Functional Information from PROSITE/UniProt
site_idPS00470
Number of Residues20
DetailsIDH_IMDH Isocitrate and isopropylmalate dehydrogenases signature. NYDGDVqSDivAqgf.GSLGL
ChainResidueDetails
AASN273-LEU292

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues66
DetailsBINDING: BINDING => ECO:0000250
ChainResidueDetails
BTHR78
BARG83
BSER95
BARG110
BARG133
BASP254
BLYS262
BASP277
BGLY312
BASN330
CTHR76
CTHR78
CARG83
CSER95
CARG110
CARG133
CASP254
CLYS262
CASP277
CGLY312
CASN330
DTHR76
DTHR78
DARG83
DSER95
DARG110
DARG133
DASP254
DLYS262
DASP277
DGLY312
DASN330
ETHR76
ETHR78
EARG83
ESER95
EARG110
EARG133
EASP254
ELYS262
EASP277
EGLY312
EASN330
FTHR76
FTHR78
FARG83
FSER95
FARG110
FARG133
FASP254
FLYS262
FASP277
FGLY312
FASN330
ATHR76
ATHR78
AARG83
ASER95
AARG110
AARG133
AASP254
ALYS262
AASP277
AGLY312
AASN330
BTHR76

site_idSWS_FT_FI2
Number of Residues12
DetailsSITE: Critical for catalysis => ECO:0000250
ChainResidueDetails
ATYR140
ALYS214
BTYR140
BLYS214
CTYR140
CLYS214
DTYR140
DLYS214
ETYR140
ELYS214
FTYR140
FLYS214

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PDB entries from 2024-06-12

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