2P1D

Crystal structure of dengue methyltransferase in complex with GTP and S-Adenosyl-L-homocysteine

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003968	molecular_function	RNA-dependent RNA polymerase activity
A	0004482	molecular_function	mRNA 5'-cap (guanine-N7-)-methyltransferase activity
A	0004483	molecular_function	mRNA (nucleoside-2'-O-)-methyltransferase activity
A	0005524	molecular_function	ATP binding
A	0008168	molecular_function	methyltransferase activity
A	0032259	biological_process	methylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 901

Chain	Residue
A	GLY109
A	HIS110
A	GLU111
A	SAH911

---

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 A 902

Chain	Residue
A	PRO152
A	ARG160
A	LYS105
A	HIS110
A	GLU149
A	SER150
A	SER151

---

site_id	AC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 A 903

Chain	Residue
A	ARG57
A	LYS61

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A 904

Chain	Residue
A	ARG38
A	LYS42
A	VAL55
A	SER56
A	ARG57
A	ARG84

---

site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 905

Chain	Residue
A	SER230
A	ASN233
A	ARG237

---

site_id	AC6
Number of Residues	1
Details	BINDING SITE FOR RESIDUE SO4 A 906

Chain	Residue
A	LYS12

---

site_id	AC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 907

Chain	Residue
A	LYS30
A	ARG57
A	ARG212

---

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 908

Chain	Residue
A	HIS52
A	ARG246
A	HIS247
A	LYS248

---

site_id	AC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 909

Chain	Residue
A	LYS105
A	ASP131
A	ARG160
A	ARG163
A	SAH911

---

site_id	BC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A 910

Chain	Residue
A	HIS52
A	GLU67
A	ARG68
A	HIS247
A	GLU253
A	HOH920

---

site_id	BC2
Number of Residues	17
Details	BINDING SITE FOR RESIDUE SAH A 911

Chain	Residue
A	SER56
A	GLY58
A	GLY81
A	CYS82
A	GLY83
A	GLY86
A	TRP87
A	THR104
A	LYS105
A	VAL130
A	ASP131
A	VAL132
A	PHE133
A	ASP146
A	SO4901
A	SO4909
A	HOH913

---

site_id	BC3
Number of Residues	9
Details	BINDING SITE FOR RESIDUE 5GP A 912

Chain	Residue
A	LYS14
A	LEU17
A	ASN18
A	LEU20
A	PHE25
A	LYS29
A	SER150
A	SER151
A	PRO152

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: For 2'-O-MTase activity => ECO:0000250|UniProtKB:Q6YMS4

Chain	Residue	Details
A	LYS61
A	ASP146
A	LYS181
A	GLU217

---

site_id	SWS_FT_FI2
Number of Residues	9
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00924

Chain	Residue	Details
A	SER56
A	GLY86
A	TRP87
A	THR104
A	LYS105
A	ASP131
A	VAL132
A	ILE147
A	TYR219

---

site_id	SWS_FT_FI3
Number of Residues	7
Details	SITE: mRNA cap binding => ECO:0000255|PROSITE-ProRule:PRU00924

Chain	Residue	Details
A	LYS14
A	ASN18
A	PHE25
A	LYS29
A	SER150
A	ARG212
A	SER214

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	SITE: mRNA cap binding; via carbonyl oxygen => ECO:0000255|PROSITE-ProRule:PRU00924

Chain	Residue	Details
A	LEU17
A	LEU20

---

site_id	SWS_FT_FI5
Number of Residues	3
Details	SITE: Essential for 2'-O-methyltransferase activity => ECO:0000255|PROSITE-ProRule:PRU00924

Chain	Residue	Details
A	LYS61
A	LYS181
A	GLU217

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	SITE: Essential for 2'-O-methyltransferase and N-7 methyltransferase activity => ECO:0000255|PROSITE-ProRule:PRU00924

Chain	Residue	Details
A	ASP146

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P03314

Chain	Residue	Details
A	SER56

---