2OI0

Crystal structure analysis 0f the TNF-a Coverting Enzyme (TACE) in complexed with Aryl-sulfonamide

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004222	molecular_function	metalloendopeptidase activity
A	0006508	biological_process	proteolysis
A	0008237	molecular_function	metallopeptidase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 2

Chain	Residue
A	2831
A	HIS405
A	HIS409
A	HIS415

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site_id	AC2
Number of Residues	12
Details	BINDING SITE FOR RESIDUE 283 A 1

Chain	Residue
A	HIS405
A	GLU406
A	HIS409
A	VAL434
A	ALA439
A	HOH500
A	HOH600
A	ZN2
A	THR347
A	LEU348
A	GLY349
A	LEU401

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Functional Information from PROSITE/UniProt

site_id	PS00142
Number of Residues	10
Details	ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. VTTHELGHNF

Chain	Residue	Details
A	VAL402-PHE411

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU00276, ECO:0000255|PROSITE-ProRule:PRU10095, ECO:0000269|PubMed:9520379

Chain	Residue	Details
A	GLU406

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site_id	SWS_FT_FI2
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|PubMed:9520379

Chain	Residue	Details
A	HIS405
A	HIS409
A	HIS415

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site_id	SWS_FT_FI3
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN264
A	GLN452

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