2OGY
Asn199Ala Mutant of the 5-methyltetrahydrofolate corrinoid/iron sulfur protein methyltransferase complexed with methyltetrahydrofolate to 2.3 Angstrom resolution
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005509 | molecular_function | calcium ion binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005829 | cellular_component | cytosol |
| A | 0008168 | molecular_function | methyltransferase activity |
| A | 0008705 | molecular_function | methionine synthase activity |
| A | 0009086 | biological_process | methionine biosynthetic process |
| A | 0015977 | biological_process | carbon fixation |
| A | 0031419 | molecular_function | cobalamin binding |
| A | 0032259 | biological_process | methylation |
| A | 0042558 | biological_process | pteridine-containing compound metabolic process |
| A | 0044237 | biological_process | cellular metabolic process |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0102036 | molecular_function | methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase activity |
| B | 0005509 | molecular_function | calcium ion binding |
| B | 0005515 | molecular_function | protein binding |
| B | 0005829 | cellular_component | cytosol |
| B | 0008168 | molecular_function | methyltransferase activity |
| B | 0008705 | molecular_function | methionine synthase activity |
| B | 0009086 | biological_process | methionine biosynthetic process |
| B | 0015977 | biological_process | carbon fixation |
| B | 0031419 | molecular_function | cobalamin binding |
| B | 0032259 | biological_process | methylation |
| B | 0042558 | biological_process | pteridine-containing compound metabolic process |
| B | 0044237 | biological_process | cellular metabolic process |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0102036 | molecular_function | methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE CA A 3001 |
| Chain | Residue |
| A | GLY222 |
| A | ASP224 |
| A | HOH3027 |
| A | HOH3032 |
| A | HOH3092 |
| A | HOH3111 |
| A | HOH3127 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE CA B 4001 |
| Chain | Residue |
| B | HOH4048 |
| B | HOH4050 |
| B | HOH4062 |
| B | HOH4104 |
| B | HOH4151 |
| B | GLY222 |
| B | ASP224 |
| site_id | AC3 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE C2F A 3000 |
| Chain | Residue |
| A | GLU6 |
| A | MET11 |
| A | PHE12 |
| A | ASP75 |
| A | ASN96 |
| A | ILE120 |
| A | ASP160 |
| A | GLY196 |
| A | SER198 |
| A | GLN202 |
| A | ARG207 |
| A | ILE227 |
| A | HOH3002 |
| A | HOH3003 |
| A | HOH3008 |
| A | HOH3058 |
| A | HOH3098 |
| A | HOH3123 |
| site_id | AC4 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE C2F B 4000 |
| Chain | Residue |
| B | MET11 |
| B | PHE12 |
| B | ASP75 |
| B | ASN96 |
| B | ILE120 |
| B | LEU122 |
| B | ASP160 |
| B | GLY196 |
| B | SER198 |
| B | GLN202 |
| B | ARG207 |
| B | HOH4002 |
| B | HOH4003 |
| B | HOH4004 |
| B | HOH4006 |
| B | HOH4049 |
| B | HOH4122 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:17172470, ECO:0000269|PubMed:22419154, ECO:0007744|PDB:4DJE, ECO:0007744|PDB:4DJF |
| Chain | Residue | Details |
| A | ALA199 | |
| A | ARG207 | |
| B | ASN96 | |
| B | ASP160 | |
| B | ALA199 | |
| B | ARG207 | |
| A | ASN96 | |
| A | ASP160 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:17172470, ECO:0000269|PubMed:22419154 |
| Chain | Residue | Details |
| A | ASP224 | |
| B | LYS184 | |
| B | GLY222 | |
| B | ASP224 | |
| A | LYS184 | |
| A | GLY222 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:17172470, ECO:0000269|PubMed:22419154, ECO:0007744|PDB:4DJF |
| Chain | Residue | Details |
| A | GLN202 | |
| B | GLN202 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | SITE: Transition state stabilizer |
| Chain | Residue | Details |
| A | ALA199 | |
| B | ALA199 |
