Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2O2R

Crystal structure of the C-terminal domain of rat 10'formyltetrahydrofolate dehydrogenase in complex with NADPH

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016491	molecular_function	oxidoreductase activity
A	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
B	0016491	molecular_function	oxidoreductase activity
B	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
C	0016491	molecular_function	oxidoreductase activity
C	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
D	0016491	molecular_function	oxidoreductase activity
D	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 C 2001

Chain	Residue
A	LYS852
C	ARG554
C	HOH3216

site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 2002

Chain	Residue
A	ARG554
A	HOH3029
C	LYS852

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 B 2003

Chain	Residue
B	ARG554
D	LYS852
D	HOH3123

site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 D 2004

Chain	Residue
B	LYS852
D	ARG554
D	HOH3036

site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 B 2005

Chain	Residue
B	ARG636
B	PRO641
B	HOH3174

site_id	AC6
Number of Residues	1
Details	BINDING SITE FOR RESIDUE SO4 A 2006

Chain	Residue
A	ARG636

site_id	AC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 C 2007

Chain	Residue
C	ARG636
C	PRO641

site_id	AC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 D 2008

Chain	Residue
D	ARG636
D	PRO641

site_id	AC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 B 2009

Chain	Residue
B	ARG764
B	TYR799

site_id	BC1
Number of Residues	1
Details	BINDING SITE FOR RESIDUE SO4 C 2010

Chain	Residue
C	ARG764

site_id	BC2
Number of Residues	1
Details	BINDING SITE FOR RESIDUE SO4 A 2011

Chain	Residue
A	ARG764

site_id	BC3
Number of Residues	1
Details	BINDING SITE FOR RESIDUE SO4 D 2012

Chain	Residue
D	ARG764

site_id	BC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 C 2013

Chain	Residue
C	LYS669
C	LEU893
C	ARG894
C	ILE895
C	HOH3192
D	GLY881
D	LYS882
D	HOH3066

site_id	BC5
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 B 2014

Chain	Residue
A	GLY881
A	LYS882
B	LYS669
B	LEU893
B	ARG894
B	ILE895
B	HOH3004
B	HOH3175

site_id	BC6
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SO4 A 2015

Chain	Residue
A	LYS669
A	LEU893
A	ARG894
A	ILE895
A	HOH3159
A	HOH3174
B	GLY881
B	LYS882
B	HOH3019

site_id	BC7
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SO4 D 2016

Chain	Residue
C	GLY881
C	LYS882
D	LYS669
D	LEU893
D	ARG894
D	ILE895
D	HOH3007
D	HOH3160
D	HOH3214

site_id	BC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 C 2017

Chain	Residue
A	LEU416
A	THR417
C	LYS415
C	ARG742

site_id	BC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 C 2018

Chain	Residue
A	TYR848
C	ARG551
C	ARG554

site_id	CC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 2019

Chain	Residue
A	ARG551
A	ARG554
C	TYR848

site_id	CC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 B 2020

Chain	Residue
B	ARG551
B	ARG554
D	TYR848

site_id	CC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 D 2021

Chain	Residue
B	TYR848
D	ARG551
D	ARG554

site_id	CC4
Number of Residues	21
Details	BINDING SITE FOR RESIDUE NDP A 903

Chain	Residue
A	VAL570
A	ILE571
A	TRP573
A	LYS597
A	ALA599
A	GLN600
A	SER629
A	GLY630
A	GLY634
A	GLN635
A	PHE648
A	THR649
A	SER651
A	VAL654
A	HIS657
A	ILE658
A	HOH3027
A	HOH3046
A	HOH3047
A	HOH3074
A	HOH3109

site_id	CC5
Number of Residues	22
Details	BINDING SITE FOR RESIDUE NDP B 903

Chain	Residue
B	LYS597
B	ALA599
B	GLN600
B	SER629
B	GLY630
B	GLY634
B	GLN635
B	PHE648
B	THR649
B	GLY650
B	SER651
B	VAL654
B	HIS657
B	ILE658
B	HOH3023
B	HOH3083
B	HOH3110
B	HOH3137
B	HOH3144
B	VAL570
B	ILE571
B	TRP573

site_id	CC6
Number of Residues	21
Details	BINDING SITE FOR RESIDUE NDP C 903

Chain	Residue
C	VAL570
C	ILE571
C	TRP573
C	LYS597
C	ALA599
C	GLN600
C	SER629
C	GLY630
C	GLY634
C	GLN635
C	PHE648
C	THR649
C	SER651
C	VAL654
C	HIS657
C	ILE658
C	HOH3043
C	HOH3044
C	HOH3053
C	HOH3058
C	HOH3139

site_id	CC7
Number of Residues	21
Details	BINDING SITE FOR RESIDUE NDP D 903

Chain	Residue
D	VAL570
D	ILE571
D	TRP573
D	LYS597
D	ALA599
D	GLN600
D	SER629
D	GLY630
D	GLY634
D	GLN635
D	PHE648
D	SER651
D	VAL654
D	HIS657
D	ILE658
D	HOH3030
D	HOH3042
D	HOH3062
D	HOH3081
D	HOH3146
D	HOH3180

site_id	CC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL A 3001

Chain	Residue
A	TYR575
A	MET578
A	ASN706
A	CYS707
A	ILE708
A	THR866

site_id	CC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL B 3002

Chain	Residue
B	MET578
B	ASN706
B	ASN864
B	THR866

site_id	DC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL C 3003

Chain	Residue
C	TYR575
C	MET578
C	ASN706
C	ASN864
C	THR866

site_id	DC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL D 3004

Chain	Residue
D	TYR575
D	MET578
D	ASN706
D	ASN864
D	THR866

Functional Information from PROSITE/UniProt

site_id	PS00070
Number of Residues	12
Details	ALDEHYDE_DEHYDR_CYS Aldehyde dehydrogenases cysteine active site. FfNKGENCIAAG

Chain	Residue	Details
A	PHE700-GLY711

site_id	PS00687
Number of Residues	8
Details	ALDEHYDE_DEHYDR_GLU Aldehyde dehydrogenases glutamic acid active site. LELGGKSP

Chain	Residue	Details
A	LEU672-PRO679

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: Proton acceptor => ECO:0000305\|PubMed:17302434

Chain	Residue	Details
A	GLU673
B	GLU673
C	GLU673
D	GLU673

site_id	SWS_FT_FI2
Number of Residues	4
Details	ACT_SITE: Proton donor => ECO:0000305\|PubMed:17302434, ECO:0000305\|PubMed:21540484, ECO:0007744\|PDB:2O2Q, ECO:0007744\|PDB:3RHO

Chain	Residue	Details
A	CYS707
B	CYS707
C	CYS707
D	CYS707

site_id	SWS_FT_FI3
Number of Residues	16
Details	BINDING: BINDING => ECO:0000269\|PubMed:17302434, ECO:0000269\|PubMed:21540484, ECO:0007744\|PDB:2O2Q, ECO:0007744\|PDB:2O2R, ECO:0007744\|PDB:3RHJ, ECO:0007744\|PDB:3RHL, ECO:0007744\|PDB:3RHO, ECO:0007744\|PDB:3RHQ, ECO:0007744\|PDB:3RHR

Chain	Residue	Details
B	ILE571
B	LYS597
B	GLY630
B	GLY650
C	ILE571
C	LYS597
C	GLY630
C	GLY650
D	ILE571
D	LYS597
D	GLY630
D	GLY650
A	ILE571
A	LYS597
A	GLY630
A	GLY650

site_id	SWS_FT_FI4
Number of Residues	8
Details	BINDING: BINDING => ECO:0000269\|PubMed:17302434, ECO:0000269\|PubMed:21540484, ECO:0007744\|PDB:2O2Q, ECO:0007744\|PDB:3RHJ, ECO:0007744\|PDB:3RHL, ECO:0007744\|PDB:3RHO, ECO:0007744\|PDB:3RHQ, ECO:0007744\|PDB:3RHR

Chain	Residue	Details
C	GLU673
C	GLU804
D	GLU673
D	GLU804
A	GLU673
A	GLU804
B	GLU673
B	GLU804

site_id	SWS_FT_FI5
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269\|PubMed:21540484, ECO:0007744\|PDB:3RHO

Chain	Residue	Details
A	LYS757
B	LYS757
C	LYS757
D	LYS757

site_id	SWS_FT_FI6
Number of Residues	12
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:O75891

Chain	Residue	Details
B	SER631
B	SER825
C	SER629
C	SER631
C	SER825
D	SER629
D	SER631
D	SER825
A	SER629
A	SER631
A	SER825
B	SER629

site_id	SWS_FT_FI7
Number of Residues	4
Details	MOD_RES: N6-succinyllysine => ECO:0000250\|UniProtKB:Q8K009

Chain	Residue	Details
A	LYS660
B	LYS660
C	LYS660
D	LYS660

site_id	SWS_FT_FI8
Number of Residues	4
Details	MOD_RES: N6-succinyllysine => ECO:0000250\|UniProtKB:Q8R0Y6

Chain	Residue	Details
A	LYS767
B	LYS767
C	LYS767
D	LYS767

site_id	SWS_FT_FI9
Number of Residues	4
Details	MOD_RES: N6-acetyllysine => ECO:0000250\|UniProtKB:Q3SY69

Chain	Residue	Details
A	LYS882
B	LYS882
C	LYS882
D	LYS882

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	1
Details	M-CSA 766

Chain	Residue	Details
A	CYS707

site_id	MCSA2
Number of Residues	1
Details	M-CSA 766

Chain	Residue	Details
B	CYS707

site_id	MCSA3
Number of Residues	1
Details	M-CSA 766

Chain	Residue	Details
C	CYS707

site_id	MCSA4
Number of Residues	1
Details	M-CSA 766

Chain	Residue	Details
D	CYS707

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)