2O1C
Structure of the E. coli dihydroneopterin triphosphate pyrophosphohydrolase
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0008828 | molecular_function | dATP diphosphatase activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0019177 | molecular_function | dihydroneopterin triphosphate pyrophosphohydrolase activity |
| A | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
| A | 0046656 | biological_process | folic acid biosynthetic process |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0008828 | molecular_function | dATP diphosphatase activity |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0019177 | molecular_function | dihydroneopterin triphosphate pyrophosphohydrolase activity |
| B | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
| B | 0046656 | biological_process | folic acid biosynthetic process |
| B | 0046872 | molecular_function | metal ion binding |
| C | 0000287 | molecular_function | magnesium ion binding |
| C | 0008828 | molecular_function | dATP diphosphatase activity |
| C | 0016787 | molecular_function | hydrolase activity |
| C | 0019177 | molecular_function | dihydroneopterin triphosphate pyrophosphohydrolase activity |
| C | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
| C | 0046656 | biological_process | folic acid biosynthetic process |
| C | 0046872 | molecular_function | metal ion binding |
| D | 0000287 | molecular_function | magnesium ion binding |
| D | 0008828 | molecular_function | dATP diphosphatase activity |
| D | 0016787 | molecular_function | hydrolase activity |
| D | 0019177 | molecular_function | dihydroneopterin triphosphate pyrophosphohydrolase activity |
| D | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
| D | 0046656 | biological_process | folic acid biosynthetic process |
| D | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 164 |
| Chain | Residue |
| A | LYS4 |
| A | LYS7 |
| A | ARG30 |
| A | ARG90 |
| A | HOH190 |
| A | HOH253 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SO4 A 165 |
| Chain | Residue |
| A | ARG97 |
| A | ARG97 |
| A | TRP136 |
| A | HOH169 |
| A | HOH191 |
| A | HOH191 |
| A | PHE81 |
| A | GLU82 |
| A | GLU82 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 B 164 |
| Chain | Residue |
| B | LYS4 |
| B | LYS7 |
| B | ARG90 |
| site_id | AC4 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE SO4 B 163 |
| Chain | Residue |
| B | PHE81 |
| B | GLU82 |
| B | ARG97 |
| B | TRP136 |
| B | HOH169 |
| C | PHE81 |
| C | GLU82 |
| C | ARG97 |
| C | TRP136 |
| C | HOH181 |
| C | HOH182 |
| site_id | AC5 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE PPV A 163 |
| Chain | Residue |
| A | LYS7 |
| A | ARG29 |
| A | THR40 |
| A | GLY41 |
| A | SER42 |
| A | GLU56 |
| A | HOH194 |
| A | HOH198 |
| A | HOH238 |
| A | HOH282 |
| site_id | AC6 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE PPV B 165 |
| Chain | Residue |
| B | LYS7 |
| B | ARG29 |
| B | THR40 |
| B | GLY41 |
| B | SER42 |
| B | GLU56 |
| B | HOH209 |
| B | HOH315 |
| site_id | AC7 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE PPV C 163 |
| Chain | Residue |
| C | LYS7 |
| C | THR40 |
| C | GLY41 |
| C | SER42 |
| C | GLU56 |
| C | ARG90 |
| C | HOH177 |
| C | HOH245 |
| C | HOH272 |
| C | HOH274 |
Functional Information from PROSITE/UniProt
| site_id | PS00893 |
| Number of Residues | 22 |
| Details | NUDIX_BOX Nudix box signature. GsveegEtapqAAmREVkEEvT |
| Chain | Residue | Details |
| A | GLY41-THR62 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 24 |
| Details | BINDING: |
| Chain | Residue | Details |
| C | LYS7 | |
| C | ARG29 | |
| C | THR40 | |
| C | GLU56 | |
| C | GLU60 | |
| C | GLU117 | |
| D | LYS7 | |
| D | ARG29 | |
| D | THR40 | |
| D | GLU56 | |
| D | GLU60 | |
| D | GLU117 | |
| A | LYS7 | |
| A | ARG29 | |
| A | THR40 | |
| A | GLU56 | |
| A | GLU60 | |
| A | GLU117 | |
| B | LYS7 | |
| B | ARG29 | |
| B | THR40 | |
| B | GLU56 | |
| B | GLU60 | |
| B | GLU117 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000255 |
| Chain | Residue | Details |
| A | PHE81 | |
| A | SER135 | |
| B | PHE81 | |
| B | SER135 | |
| C | PHE81 | |
| C | SER135 | |
| D | PHE81 | |
| D | SER135 |
