2NS2
Crystal Structure of Spindlin1
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005730 | cellular_component | nucleolus |
| A | 0005819 | cellular_component | spindle |
| A | 0005829 | cellular_component | cytosol |
| A | 0006325 | biological_process | chromatin organization |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| A | 0007276 | biological_process | gamete generation |
| A | 0009303 | biological_process | rRNA transcription |
| A | 0016055 | biological_process | Wnt signaling pathway |
| A | 0030177 | biological_process | positive regulation of Wnt signaling pathway |
| A | 0031965 | cellular_component | nuclear membrane |
| A | 0035064 | molecular_function | methylated histone binding |
| A | 0045893 | biological_process | positive regulation of DNA-templated transcription |
| A | 0051321 | biological_process | meiotic cell cycle |
| B | 0005515 | molecular_function | protein binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005654 | cellular_component | nucleoplasm |
| B | 0005730 | cellular_component | nucleolus |
| B | 0005819 | cellular_component | spindle |
| B | 0005829 | cellular_component | cytosol |
| B | 0006325 | biological_process | chromatin organization |
| B | 0006355 | biological_process | regulation of DNA-templated transcription |
| B | 0007276 | biological_process | gamete generation |
| B | 0009303 | biological_process | rRNA transcription |
| B | 0016055 | biological_process | Wnt signaling pathway |
| B | 0030177 | biological_process | positive regulation of Wnt signaling pathway |
| B | 0031965 | cellular_component | nuclear membrane |
| B | 0035064 | molecular_function | methylated histone binding |
| B | 0045893 | biological_process | positive regulation of DNA-templated transcription |
| B | 0051321 | biological_process | meiotic cell cycle |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE PO4 A 301 |
| Chain | Residue |
| A | ARG92 |
| A | VAL93 |
| A | ALA94 |
| A | THR95 |
| A | MET137 |
| A | ASN138 |
| A | THR139 |
| A | TRP140 |
| A | HOH336 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PO4 A 302 |
| Chain | Residue |
| A | ARG97 |
| A | ILE98 |
| A | ARG133 |
| A | ASN138 |
| A | HOH306 |
| A | HOH380 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | SITE: Histone H3K4me3 and H3R8me2a binding |
| Chain | Residue | Details |
| A | ASP148 | |
| A | GLN155 | |
| A | ASP159 | |
| B | ASP148 | |
| B | GLN155 | |
| B | ASP159 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-acetyllysine; alternate => ECO:0000250|UniProtKB:Q61142 |
| Chain | Residue | Details |
| A | LYS19 | |
| B | LYS19 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine; by AURKA => ECO:0000269|PubMed:22258766 |
| Chain | Residue | Details |
| A | SER84 | |
| B | SER84 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine; by AURKA => ECO:0000269|PubMed:22258766, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER99 | |
| B | SER99 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER174 | |
| B | SER174 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 |
| Chain | Residue | Details |
| A | LYS3 | |
| B | LYS3 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 4 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:28112733 |
| Chain | Residue | Details |
| A | LYS19 | |
| B | LYS19 |
