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2KEE

Structure of SDF-1/CXCL12

Functional Information from GO Data
ChainGOidnamespacecontents
A0001666biological_processresponse to hypoxia
A0001764biological_processneuron migration
A0001938biological_processpositive regulation of endothelial cell proliferation
A0005102molecular_functionsignaling receptor binding
A0005125molecular_functioncytokine activity
A0005178molecular_functionintegrin binding
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0006874biological_processintracellular calcium ion homeostasis
A0006935biological_processchemotaxis
A0006952biological_processdefense response
A0006955biological_processimmune response
A0007155biological_processcell adhesion
A0007165biological_processsignal transduction
A0007186biological_processG protein-coupled receptor signaling pathway
A0007411biological_processaxon guidance
A0008009molecular_functionchemokine activity
A0008015biological_processblood circulation
A0008064biological_processregulation of actin polymerization or depolymerization
A0008083molecular_functiongrowth factor activity
A0008284biological_processpositive regulation of cell population proliferation
A0008344biological_processadult locomotory behavior
A0009612biological_processresponse to mechanical stimulus
A0009615biological_processresponse to virus
A0009897cellular_componentexternal side of plasma membrane
A0022029biological_processtelencephalon cell migration
A0030335biological_processpositive regulation of cell migration
A0031100biological_processanimal organ regeneration
A0033603biological_processpositive regulation of dopamine secretion
A0033622biological_processintegrin activation
A0038146biological_processchemokine (C-X-C motif) ligand 12 signaling pathway
A0038160biological_processCXCL12-activated CXCR4 signaling pathway
A0042379molecular_functionchemokine receptor binding
A0043434biological_processresponse to peptide hormone
A0045236molecular_functionCXCR chemokine receptor binding
A0045666biological_processpositive regulation of neuron differentiation
A0045785biological_processpositive regulation of cell adhesion
A0048842biological_processpositive regulation of axon extension involved in axon guidance
A0050930biological_processinduction of positive chemotaxis
A0050965biological_processdetection of temperature stimulus involved in sensory perception of pain
A0050966biological_processdetection of mechanical stimulus involved in sensory perception of pain
A0051924biological_processregulation of calcium ion transport
A0060326biological_processcell chemotaxis
A0062023cellular_componentcollagen-containing extracellular matrix
A0070062cellular_componentextracellular exosome
A0070098biological_processchemokine-mediated signaling pathway
A0090026biological_processpositive regulation of monocyte chemotaxis
A0090280biological_processpositive regulation of calcium ion import
A1902230biological_processnegative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
A1903237biological_processnegative regulation of leukocyte tethering or rolling
A1904018biological_processpositive regulation of vasculature development
A1990478biological_processresponse to ultrasound
A1990869biological_processcellular response to chemokine
A2000406biological_processpositive regulation of T cell migration
A2000669biological_processnegative regulation of dendritic cell apoptotic process
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsBINDING:
ChainResidueDetails
AARG20
AARG41
AGLN48
ALYS64

site_idSWS_FT_FI2
Number of Residues3
DetailsSITE: Important for integrin interaction and activation => ECO:0000269|PubMed:29301984
ChainResidueDetails
ALYS24
ALYS27
ALYS43

site_idSWS_FT_FI3
Number of Residues1
DetailsSITE: Important for dimer formation
ChainResidueDetails
AHIS25

218853

PDB entries from 2024-04-24

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