2JCL
Crystal structure of alpha-1,3 Galactosyltransferase (R365K) in the absence of ligands
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005975 | biological_process | carbohydrate metabolic process |
| A | 0016020 | cellular_component | membrane |
| A | 0016758 | molecular_function | hexosyltransferase activity |
| B | 0005975 | biological_process | carbohydrate metabolic process |
| B | 0016020 | cellular_component | membrane |
| B | 0016758 | molecular_function | hexosyltransferase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 B3360 |
| Chain | Residue |
| A | GLN1247 |
| A | TRP1249 |
| B | GLU2192 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 B3361 |
| Chain | Residue |
| B | ARG2202 |
| B | ILE2206 |
| B | ASP2225 |
| B | ALA2281 |
| B | PHE2284 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B3362 |
| Chain | Residue |
| B | CYS2298 |
| B | HIS2319 |
| B | TYR2323 |
| B | GLU2297 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 B3363 |
| Chain | Residue |
| B | VAL2211 |
| B | HIS2216 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 B3364 |
| Chain | Residue |
| B | MET2166 |
| B | LYS2188 |
| B | ILE2189 |
| B | LYS2190 |
| B | LYS2193 |
| B | THR2205 |
| B | GLU2208 |
| B | HIS2209 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Nucleophile => ECO:0000269|PubMed:11179209, ECO:0007744|PDB:1G8O |
| Chain | Residue | Details |
| A | GLU1317 | |
| B | GLU2317 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:11179209, ECO:0000269|PubMed:11592969, ECO:0000269|PubMed:12011052, ECO:0007744|PDB:1G93, ECO:0007744|PDB:1GWV, ECO:0007744|PDB:1GWW, ECO:0007744|PDB:1GX0, ECO:0007744|PDB:1GX4, ECO:0007744|PDB:1K4V, ECO:0007744|PDB:1O7O, ECO:0007744|PDB:1O7Q, ECO:0007744|PDB:1VZT, ECO:0007744|PDB:1VZU, ECO:0007744|PDB:1VZX, ECO:0007744|PDB:2JCK, ECO:0007744|PDB:2VFZ, ECO:0007744|PDB:2VS3, ECO:0007744|PDB:2VS4, ECO:0007744|PDB:2VS5, ECO:0007744|PDB:2VXL, ECO:0007744|PDB:2WGZ |
| Chain | Residue | Details |
| A | PHE1134 | |
| B | PHE2134 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:11179209, ECO:0000269|PubMed:11592969, ECO:0000269|PubMed:12011052, ECO:0007744|PDB:1G8O, ECO:0007744|PDB:1G93, ECO:0007744|PDB:1GWV, ECO:0007744|PDB:1GWW, ECO:0007744|PDB:1GX0, ECO:0007744|PDB:1GX4, ECO:0007744|PDB:1K4V, ECO:0007744|PDB:1O7O, ECO:0007744|PDB:1O7Q, ECO:0007744|PDB:1VZT, ECO:0007744|PDB:1VZU, ECO:0007744|PDB:1VZX, ECO:0007744|PDB:2JCK, ECO:0007744|PDB:2VFZ, ECO:0007744|PDB:2VS3, ECO:0007744|PDB:2VS4, ECO:0007744|PDB:2VS5, ECO:0007744|PDB:2VXL, ECO:0007744|PDB:2WGZ |
| Chain | Residue | Details |
| B | ASP2225 | |
| B | ASP2227 | |
| A | ASP1225 | |
| A | ASP1227 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:12011052, ECO:0007744|PDB:1GWV, ECO:0007744|PDB:1GX4, ECO:0007744|PDB:1O7O, ECO:0007744|PDB:1O7Q, ECO:0007744|PDB:1VZX, ECO:0007744|PDB:2VS4, ECO:0007744|PDB:2WGZ |
| Chain | Residue | Details |
| B | GLN2247 | |
| B | THR2259 | |
| A | GLN1247 | |
| A | THR1259 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:11592969, ECO:0000269|PubMed:12011052, ECO:0007744|PDB:1GWV, ECO:0007744|PDB:1GWW, ECO:0007744|PDB:1GX0, ECO:0007744|PDB:1GX4, ECO:0007744|PDB:1K4V, ECO:0007744|PDB:1O7O, ECO:0007744|PDB:1O7Q, ECO:0007744|PDB:1VZT, ECO:0007744|PDB:1VZU, ECO:0007744|PDB:1VZX, ECO:0007744|PDB:2JCK, ECO:0007744|PDB:2VFZ, ECO:0007744|PDB:2VS3, ECO:0007744|PDB:2VS4, ECO:0007744|PDB:2VS5, ECO:0007744|PDB:2WGZ |
| Chain | Residue | Details |
| A | LYS1359 | |
| B | LYS2359 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN1293 | |
| B | ASN2293 |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 6 |
| Details | M-CSA 356 |
| Chain | Residue | Details |
| A | GLN1247 | electrostatic stabiliser, hydrogen bond donor |
| A | HIS1280 | electrostatic stabiliser, hydrogen bond donor |
| A | TRP1314 | electrostatic stabiliser, hydrogen bond donor |
| A | GLU1317 | activator, covalently attached, electrostatic stabiliser, nucleofuge, nucleophile |
| A | TRP1356 | electrostatic stabiliser, hydrogen bond donor |
| A | LYS1365 | electrostatic stabiliser |
| site_id | MCSA2 |
| Number of Residues | 6 |
| Details | M-CSA 356 |
| Chain | Residue | Details |
| B | GLN2247 | electrostatic stabiliser, hydrogen bond donor |
| B | HIS2280 | electrostatic stabiliser, hydrogen bond donor |
| B | TRP2314 | electrostatic stabiliser, hydrogen bond donor |
| B | GLU2317 | activator, covalently attached, electrostatic stabiliser, nucleofuge, nucleophile |
| B | TRP2356 | electrostatic stabiliser, hydrogen bond donor |
| B | LYS2365 | electrostatic stabiliser |
