2IMG

Crystal structure of dual specificity protein phosphatase 23 from Homo sapiens in complex with ligand malate ion

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004721	molecular_function	phosphoprotein phosphatase activity
A	0004722	molecular_function	protein serine/threonine phosphatase activity
A	0004725	molecular_function	protein tyrosine phosphatase activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006470	biological_process	protein dephosphorylation
A	0008138	molecular_function	protein tyrosine/serine/threonine phosphatase activity
A	0016311	biological_process	dephosphorylation
A	0016791	molecular_function	phosphatase activity
A	0017018	molecular_function	myosin phosphatase activity
A	0060271	biological_process	cilium assembly

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	BINDING SITE FOR RESIDUE MLT A 501

Chain	Residue
A	PHE66
A	LYS140
A	HOH519
A	CYS95
A	ALA96
A	LEU97
A	GLY98
A	PHE99
A	GLY100
A	ARG101
A	TYR136

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Functional Information from PROSITE/UniProt

site_id	PS00383
Number of Residues	11
Details	TYR_PHOSPHATASE_1 Tyrosine specific protein phosphatases active site. VHCalGfgRTG

Chain	Residue	Details
A	VAL93-GLY103

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Phosphocysteine intermediate => ECO:0000255|PROSITE-ProRule:PRU00160

Chain	Residue	Details
A	CYS95

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