2I4I
Crystal Structure of human DEAD-box RNA helicase DDX3X
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE AMP A 600 |
| Chain | Residue |
| A | TYR200 |
| A | HOH609 |
| A | HOH670 |
| A | HOH683 |
| A | HOH687 |
| A | HOH782 |
| A | ARG202 |
| A | GLN207 |
| A | THR226 |
| A | GLY227 |
| A | SER228 |
| A | GLY229 |
| A | LYS230 |
| A | THR231 |
Functional Information from PROSITE/UniProt
| site_id | PS00039 |
| Number of Residues | 9 |
| Details | DEAD_ATP_HELICASE DEAD-box subfamily ATP-dependent helicases signature. VLDEADRmL |
| Chain | Residue | Details |
| A | VAL345-LEU353 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | THR201 | |
| A | GLN225 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | MOD_RES: Phosphoserine; by TBK1; in vitro => ECO:0000269|PubMed:18583960 |
| Chain | Residue | Details |
| A | PHE182 | |
| A | GLN241 | |
| A | LEU270 | |
| A | LEU443 | |
| A | LEU457 | |
| A | ASP521 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine; by TBK1 => ECO:0000269|PubMed:18583960, ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| A | ASP184 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine; by CSNK1E and TBK1; in vitro => ECO:0000269|PubMed:18583960, ECO:0000269|PubMed:29222110 |
| Chain | Residue | Details |
| A | PHE430 | |
| A | PHE544 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine; by TBK1; in vitro => ECO:0000269|PubMed:18583960 |
| Chain | Residue | Details |
| A | GLY439 | |
| A | SER543 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine; by CSNK1E; in vitro => ECO:0000269|PubMed:29222110 |
| Chain | Residue | Details |
| A | SER470 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine; by CSNK1E; in vitro => ECO:0000269|PubMed:29222110 |
| Chain | Residue | Details |
| A | ILE471 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:25218447, ECO:0007744|PubMed:28112733 |
| Chain | Residue | Details |
| A | GLU216 |
