2HRT
Asymmetric structure of trimeric AcrB from Escherichia coli
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005515 | molecular_function | protein binding |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0015562 | molecular_function | efflux transmembrane transporter activity |
| A | 0016020 | cellular_component | membrane |
| A | 0022857 | molecular_function | transmembrane transporter activity |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0042908 | biological_process | xenobiotic transport |
| A | 0042910 | molecular_function | xenobiotic transmembrane transporter activity |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0098567 | cellular_component | periplasmic side of plasma membrane |
| A | 0140330 | biological_process | xenobiotic detoxification by transmembrane export across the cell outer membrane |
| A | 1990281 | cellular_component | efflux pump complex |
| B | 0005515 | molecular_function | protein binding |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0015562 | molecular_function | efflux transmembrane transporter activity |
| B | 0016020 | cellular_component | membrane |
| B | 0022857 | molecular_function | transmembrane transporter activity |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0042908 | biological_process | xenobiotic transport |
| B | 0042910 | molecular_function | xenobiotic transmembrane transporter activity |
| B | 0055085 | biological_process | transmembrane transport |
| B | 0098567 | cellular_component | periplasmic side of plasma membrane |
| B | 0140330 | biological_process | xenobiotic detoxification by transmembrane export across the cell outer membrane |
| B | 1990281 | cellular_component | efflux pump complex |
| C | 0005515 | molecular_function | protein binding |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0015562 | molecular_function | efflux transmembrane transporter activity |
| C | 0016020 | cellular_component | membrane |
| C | 0022857 | molecular_function | transmembrane transporter activity |
| C | 0042802 | molecular_function | identical protein binding |
| C | 0042908 | biological_process | xenobiotic transport |
| C | 0042910 | molecular_function | xenobiotic transmembrane transporter activity |
| C | 0055085 | biological_process | transmembrane transport |
| C | 0098567 | cellular_component | periplasmic side of plasma membrane |
| C | 0140330 | biological_process | xenobiotic detoxification by transmembrane export across the cell outer membrane |
| C | 1990281 | cellular_component | efflux pump complex |
| D | 0005515 | molecular_function | protein binding |
| D | 0005886 | cellular_component | plasma membrane |
| D | 0015562 | molecular_function | efflux transmembrane transporter activity |
| D | 0016020 | cellular_component | membrane |
| D | 0022857 | molecular_function | transmembrane transporter activity |
| D | 0042802 | molecular_function | identical protein binding |
| D | 0042908 | biological_process | xenobiotic transport |
| D | 0042910 | molecular_function | xenobiotic transmembrane transporter activity |
| D | 0055085 | biological_process | transmembrane transport |
| D | 0098567 | cellular_component | periplasmic side of plasma membrane |
| D | 0140330 | biological_process | xenobiotic detoxification by transmembrane export across the cell outer membrane |
| D | 1990281 | cellular_component | efflux pump complex |
| E | 0005515 | molecular_function | protein binding |
| E | 0005886 | cellular_component | plasma membrane |
| E | 0015562 | molecular_function | efflux transmembrane transporter activity |
| E | 0016020 | cellular_component | membrane |
| E | 0022857 | molecular_function | transmembrane transporter activity |
| E | 0042802 | molecular_function | identical protein binding |
| E | 0042908 | biological_process | xenobiotic transport |
| E | 0042910 | molecular_function | xenobiotic transmembrane transporter activity |
| E | 0055085 | biological_process | transmembrane transport |
| E | 0098567 | cellular_component | periplasmic side of plasma membrane |
| E | 0140330 | biological_process | xenobiotic detoxification by transmembrane export across the cell outer membrane |
| E | 1990281 | cellular_component | efflux pump complex |
| F | 0005515 | molecular_function | protein binding |
| F | 0005886 | cellular_component | plasma membrane |
| F | 0015562 | molecular_function | efflux transmembrane transporter activity |
| F | 0016020 | cellular_component | membrane |
| F | 0022857 | molecular_function | transmembrane transporter activity |
| F | 0042802 | molecular_function | identical protein binding |
| F | 0042908 | biological_process | xenobiotic transport |
| F | 0042910 | molecular_function | xenobiotic transmembrane transporter activity |
| F | 0055085 | biological_process | transmembrane transport |
| F | 0098567 | cellular_component | periplasmic side of plasma membrane |
| F | 0140330 | biological_process | xenobiotic detoxification by transmembrane export across the cell outer membrane |
| F | 1990281 | cellular_component | efflux pump complex |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE FLC B 1058 |
| Chain | Residue |
| A | ILE763 |
| B | LYS55 |
| B | GLN58 |
| B | ASP59 |
| B | GLY691 |
| B | HIS692 |
| B | LEU816 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE FLC A 1058 |
| Chain | Residue |
| A | ASP59 |
| A | HIS692 |
| C | ILE763 |
| A | LYS55 |
| A | GLN58 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE FLC E 1058 |
| Chain | Residue |
| D | ILE763 |
| E | LYS55 |
| E | GLN58 |
| E | ASP59 |
| E | GLY691 |
| E | HIS692 |
| E | LEU816 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE FLC D 1058 |
| Chain | Residue |
| D | LYS55 |
| D | GLN58 |
| D | ASP59 |
| D | GLY691 |
| D | HIS692 |
| F | ILE763 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 924 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:15919996 |
| Chain | Residue | Details |
| A | MET1-PRO9 | |
| A | GLU414-ILE438 | |
| A | ALA491-THR538 | |
| A | ALA889-PRO898 | |
| A | LEU944-LEU972 | |
| A | ILE1019-HIS1049 | |
| B | MET1-PRO9 | |
| B | LEU357-THR365 | |
| B | GLU414-ILE438 | |
| B | ALA491-THR538 | |
| B | ALA889-PRO898 | |
| B | LEU944-LEU972 | |
| B | ILE1019-HIS1049 | |
| C | MET1-PRO9 | |
| C | LEU357-THR365 | |
| C | GLU414-ILE438 | |
| C | ALA491-THR538 | |
| C | ALA889-PRO898 | |
| C | LEU944-LEU972 | |
| C | ILE1019-HIS1049 | |
| D | MET1-PRO9 | |
| D | LEU357-THR365 | |
| D | ALA889-PRO898 | |
| D | LEU944-LEU972 | |
| D | ILE1019-HIS1049 | |
| E | MET1-PRO9 | |
| E | LEU357-THR365 | |
| E | GLU414-ILE438 | |
| E | ALA491-THR538 | |
| E | ALA889-PRO898 | |
| E | LEU944-LEU972 | |
| E | ILE1019-HIS1049 | |
| F | MET1-PRO9 | |
| F | LEU357-THR365 | |
| F | GLU414-ILE438 | |
| F | ALA491-THR538 | |
| F | ALA889-PRO898 | |
| F | LEU944-LEU972 | |
| A | LEU357-THR365 | |
| D | GLU414-ILE438 | |
| D | ALA491-THR538 | |
| F | ILE1019-HIS1049 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 108 |
| Details | TRANSMEM: Helical; Name=1 |
| Chain | Residue | Details |
| B | ILE10-LEU28 | |
| C | ILE10-LEU28 | |
| D | ILE10-LEU28 | |
| E | ILE10-LEU28 | |
| F | ILE10-LEU28 | |
| A | ILE10-LEU28 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3864 |
| Details | TOPO_DOM: Periplasmic => ECO:0000269|PubMed:15919996 |
| Chain | Residue | Details |
| A | PHE458-ALA465 | |
| A | PHE556-ASN871 | |
| A | ARG919-ASP924 | |
| A | THR993-GLY998 | |
| B | LYS29-SER336 | |
| B | PHE386-ASN391 | |
| B | PHE458-ALA465 | |
| B | PHE556-ASN871 | |
| B | ARG919-ASP924 | |
| B | THR993-GLY998 | |
| C | LYS29-SER336 | |
| C | PHE386-ASN391 | |
| C | PHE458-ALA465 | |
| C | PHE556-ASN871 | |
| C | ARG919-ASP924 | |
| C | THR993-GLY998 | |
| D | LYS29-SER336 | |
| D | PHE556-ASN871 | |
| D | ARG919-ASP924 | |
| D | THR993-GLY998 | |
| E | LYS29-SER336 | |
| E | PHE386-ASN391 | |
| E | PHE458-ALA465 | |
| E | PHE556-ASN871 | |
| E | ARG919-ASP924 | |
| E | THR993-GLY998 | |
| F | LYS29-SER336 | |
| F | PHE386-ASN391 | |
| F | PHE458-ALA465 | |
| F | PHE556-ASN871 | |
| F | ARG919-ASP924 | |
| A | LYS29-SER336 | |
| A | PHE386-ASN391 | |
| D | PHE386-ASN391 | |
| D | PHE458-ALA465 | |
| F | THR993-GLY998 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 114 |
| Details | TRANSMEM: Helical; Name=2 |
| Chain | Residue | Details |
| B | ILE337-TYR356 | |
| C | ILE337-TYR356 | |
| D | ILE337-TYR356 | |
| E | ILE337-TYR356 | |
| F | ILE337-TYR356 | |
| A | ILE337-TYR356 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 114 |
| Details | TRANSMEM: Helical; Name=3 |
| Chain | Residue | Details |
| B | LEU366-ALA385 | |
| C | LEU366-ALA385 | |
| E | LEU366-ALA385 | |
| F | LEU366-ALA385 | |
| A | LEU366-ALA385 | |
| D | LEU366-ALA385 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 126 |
| Details | TRANSMEM: Helical; Name=4 |
| Chain | Residue | Details |
| B | THR392-VAL413 | |
| C | THR392-VAL413 | |
| E | THR392-VAL413 | |
| F | THR392-VAL413 | |
| A | THR392-VAL413 | |
| D | THR392-VAL413 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 108 |
| Details | TRANSMEM: Helical; Name=5 |
| Chain | Residue | Details |
| A | GLN439-ALA457 | |
| B | GLN439-ALA457 | |
| C | GLN439-ALA457 | |
| E | GLN439-ALA457 | |
| F | GLN439-ALA457 | |
| D | GLN439-ALA457 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 144 |
| Details | TRANSMEM: Helical; Name=6 |
| Chain | Residue | Details |
| A | ILE466-PRO490 | |
| B | ILE466-PRO490 | |
| C | ILE466-PRO490 | |
| E | ILE466-PRO490 | |
| F | ILE466-PRO490 | |
| D | ILE466-PRO490 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 96 |
| Details | TRANSMEM: Helical; Name=7 |
| Chain | Residue | Details |
| A | GLY539-LEU555 | |
| B | GLY539-LEU555 | |
| C | GLY539-LEU555 | |
| D | GLY539-LEU555 | |
| E | GLY539-LEU555 | |
| F | GLY539-LEU555 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 96 |
| Details | TRANSMEM: Helical; Name=8 |
| Chain | Residue | Details |
| A | GLN872-LEU888 | |
| B | GLN872-LEU888 | |
| C | GLN872-LEU888 | |
| D | GLN872-LEU888 | |
| E | GLN872-LEU888 | |
| F | GLN872-LEU888 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 114 |
| Details | TRANSMEM: Helical; Name=9 |
| Chain | Residue | Details |
| A | PHE899-PHE918 | |
| B | PHE899-PHE918 | |
| C | PHE899-PHE918 | |
| D | PHE899-PHE918 | |
| E | PHE899-PHE918 | |
| F | PHE899-PHE918 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 108 |
| Details | TRANSMEM: Helical; Name=10 |
| Chain | Residue | Details |
| A | VAL925-ILE943 | |
| B | VAL925-ILE943 | |
| C | VAL925-ILE943 | |
| D | VAL925-ILE943 | |
| E | VAL925-ILE943 | |
| F | VAL925-ILE943 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 114 |
| Details | TRANSMEM: Helical; Name=11 |
| Chain | Residue | Details |
| A | ARG973-SER992 | |
| B | ARG973-SER992 | |
| C | ARG973-SER992 | |
| D | ARG973-SER992 | |
| E | ARG973-SER992 | |
| F | ARG973-SER992 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 114 |
| Details | TRANSMEM: Helical; Name=12 |
| Chain | Residue | Details |
| A | ALA999-ALA1018 | |
| B | ALA999-ALA1018 | |
| C | ALA999-ALA1018 | |
| D | ALA999-ALA1018 | |
| E | ALA999-ALA1018 | |
| F | ALA999-ALA1018 |
