Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2HLZ

Crystal Structure of human ketohexokinase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004454	molecular_function	ketohexokinase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006000	biological_process	fructose metabolic process
A	0006796	biological_process	phosphate-containing compound metabolic process
A	0009744	biological_process	response to sucrose
A	0009749	biological_process	response to glucose
A	0009750	biological_process	response to fructose
A	0010043	biological_process	response to zinc ion
A	0016301	molecular_function	kinase activity
A	0032868	biological_process	response to insulin
A	0046835	biological_process	carbohydrate phosphorylation
A	0070062	cellular_component	extracellular exosome
A	0070873	biological_process	regulation of glycogen metabolic process
B	0004454	molecular_function	ketohexokinase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006000	biological_process	fructose metabolic process
B	0006796	biological_process	phosphate-containing compound metabolic process
B	0009744	biological_process	response to sucrose
B	0009749	biological_process	response to glucose
B	0009750	biological_process	response to fructose
B	0010043	biological_process	response to zinc ion
B	0016301	molecular_function	kinase activity
B	0032868	biological_process	response to insulin
B	0046835	biological_process	carbohydrate phosphorylation
B	0070062	cellular_component	extracellular exosome
B	0070873	biological_process	regulation of glycogen metabolic process
C	0004454	molecular_function	ketohexokinase activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006000	biological_process	fructose metabolic process
C	0006796	biological_process	phosphate-containing compound metabolic process
C	0009744	biological_process	response to sucrose
C	0009749	biological_process	response to glucose
C	0009750	biological_process	response to fructose
C	0010043	biological_process	response to zinc ion
C	0016301	molecular_function	kinase activity
C	0032868	biological_process	response to insulin
C	0046835	biological_process	carbohydrate phosphorylation
C	0070062	cellular_component	extracellular exosome
C	0070873	biological_process	regulation of glycogen metabolic process
D	0004454	molecular_function	ketohexokinase activity
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006000	biological_process	fructose metabolic process
D	0006796	biological_process	phosphate-containing compound metabolic process
D	0009744	biological_process	response to sucrose
D	0009749	biological_process	response to glucose
D	0009750	biological_process	response to fructose
D	0010043	biological_process	response to zinc ion
D	0016301	molecular_function	kinase activity
D	0032868	biological_process	response to insulin
D	0046835	biological_process	carbohydrate phosphorylation
D	0070062	cellular_component	extracellular exosome
D	0070873	biological_process	regulation of glycogen metabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE UNX A 701

Chain	Residue
A	ALA256
A	GLY257
A	HOH375

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE UNX B 702

Chain	Residue
B	THR253
B	ALA256
B	GLY257
B	HOH369

site_id	AC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE UNX C 703

Chain	Residue
C	GLY255
C	GLY257

site_id	AC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE UNX D 704

Chain	Residue
D	ARG108

site_id	AC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE UNX B 706

Chain	Residue
B	HIS156

site_id	AC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE UNX A 707

Chain	Residue
A	ALA143
A	SER144

site_id	AC7
Number of Residues	1
Details	BINDING SITE FOR RESIDUE UNX A 708

Chain	Residue
A	ARG31

site_id	AC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE UNX D 709

Chain	Residue
D	VAL68
D	ARG115

site_id	AC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE UNX B 710

Chain	Residue
B	ARG272
B	SER273
B	GLU276

site_id	BC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE UNX B 711

Chain	Residue
B	ALA226
B	GLY229

site_id	BC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE UNX A 712

Chain	Residue
A	ARG115
A	HOH316

site_id	BC3
Number of Residues	1
Details	BINDING SITE FOR RESIDUE UNX A 713

Chain	Residue
A	ALA226

site_id	BC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE UNX D 714

Chain	Residue
D	HIS156

site_id	BC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE UNX A 715

Chain	Residue
A	ILE96

site_id	BC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE UNX C 716

Chain	Residue
B	HOH513
C	ILE96

site_id	BC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE UNX D 717

Chain	Residue
D	ALA226
D	GLY229

site_id	BC8
Number of Residues	1
Details	BINDING SITE FOR RESIDUE UNX B 718

Chain	Residue
B	ARG115

site_id	BC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE UNX D 719

Chain	Residue
B	GLU227
D	SER203
D	GLU205

site_id	CC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE UNX B 721

Chain	Residue
B	ALA143
B	GLU178

site_id	CC2
Number of Residues	1
Details	BINDING SITE FOR RESIDUE UNX C 722

Chain	Residue
C	HIS156

site_id	CC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE UNX C 723

Chain	Residue
C	ALA226
C	GLY229

site_id	CC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE UNX C 724

Chain	Residue
C	ARG115

site_id	CC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE UNX A 726

Chain	Residue
A	ARG77
C	LYS127

site_id	CC6
Number of Residues	1
Details	BINDING SITE FOR RESIDUE UNX D 727

Chain	Residue
D	SER273

site_id	CC7
Number of Residues	1
Details	BINDING SITE FOR RESIDUE UNX D 728

Chain	Residue
D	SER267

site_id	CC8
Number of Residues	1
Details	BINDING SITE FOR RESIDUE UNX C 729

Chain	Residue
D	HIS198

site_id	CC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE UNX C 730

Chain	Residue
C	ASP15
C	GLY41

site_id	DC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE UNX B 731

Chain	Residue
B	ASP70
D	ARG77

site_id	DC2
Number of Residues	1
Details	BINDING SITE FOR RESIDUE UNX A 732

Chain	Residue
A	SER273

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269\|PubMed:19237742, ECO:0007744\|PDB:2HW1

Chain	Residue	Details
A	ASP15
B	ASP15
C	ASP15
D	ASP15

site_id	SWS_FT_FI2
Number of Residues	16
Details	BINDING: BINDING => ECO:0007744\|PDB:2HW1

Chain	Residue	Details
B	GLY41
B	ASN42
B	ASN45
B	ASP258
C	GLY41
C	ASN42
C	ASN45
C	ASP258
D	GLY41
D	ASN42
D	ASN45
D	ASP258
A	GLY41
A	ASN42
A	ASN45
A	ASP258

site_id	SWS_FT_FI3
Number of Residues	12
Details	BINDING: BINDING => ECO:0000305\|PubMed:19237742, ECO:0007744\|PDB:2HW1

Chain	Residue	Details
B	ALA226
B	GLY255
C	ARG108
C	ALA226
C	GLY255
D	ARG108
D	ALA226
D	GLY255
A	ARG108
A	ALA226
A	GLY255
B	ARG108

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)