2HKY
NMR solution structure of human RNase 7
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001530 | molecular_function | lipopolysaccharide binding |
| A | 0003676 | molecular_function | nucleic acid binding |
| A | 0004519 | molecular_function | endonuclease activity |
| A | 0004540 | molecular_function | RNA nuclease activity |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005615 | cellular_component | extracellular space |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0019731 | biological_process | antibacterial humoral response |
| A | 0042742 | biological_process | defense response to bacterium |
| A | 0042834 | molecular_function | peptidoglycan binding |
| A | 0045087 | biological_process | innate immune response |
| A | 0050829 | biological_process | defense response to Gram-negative bacterium |
| A | 0050830 | biological_process | defense response to Gram-positive bacterium |
| A | 0050832 | biological_process | defense response to fungus |
| A | 0051715 | biological_process | cytolysis in another organism |
| A | 0061844 | biological_process | antimicrobial humoral immune response mediated by antimicrobial peptide |
Functional Information from PROSITE/UniProt
| site_id | PS00127 |
| Number of Residues | 7 |
| Details | RNASE_PANCREATIC Pancreatic ribonuclease family signature. CKdlNTF |
| Chain | Residue | Details |
| A | CYS37-PHE43 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: Proton acceptor => ECO:0000305|PubMed:17150966 |
| Chain | Residue | Details |
| A | HIS15 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | ACT_SITE: Proton donor => ECO:0000305|PubMed:17150966 |
| Chain | Residue | Details |
| A | HIS123 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:P15468 |
| Chain | Residue | Details |
| A | ASN41 | |
| A | THR42 | |
| A | HIS123 | |
| A | ARG126 | |
| A | HIS15 | |
| A | LYS38 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | SITE: Critical for catalytic activity => ECO:0000269|PubMed:17150966 |
| Chain | Residue | Details |
| A | LYS38 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN99 |
